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Optimal achieved blood pressure in acute intracerebral hemorrhage INTERACT2

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dc.contributor.author Arima, Hisatomi
dc.contributor.author Heeley, Emma
dc.contributor.author Delcourt, Candice
dc.contributor.author Hirakawa, Yoichiro
dc.contributor.author Wang, Xia
dc.contributor.author Woodward, Mark
dc.contributor.author Thompson, Robinson
dc.contributor.author Stapf, Christian
dc.contributor.author Parsons, Mark
dc.contributor.author Lavados, Pablo
dc.contributor.author Huang, Yining
dc.contributor.author Wang, Jiguang
dc.contributor.author Chalmers, John
dc.contributor.author Anderson, Craig
dc.contributor.author INTERACT2 Investigators
dc.date.accessioned 2016-08-02T19:30:38Z
dc.date.available 2016-08-02T19:30:38Z
dc.date.issued 2015
dc.identifier.citation Neurology, Feb 2015, vol.84, n°5, p.464–471
dc.identifier.uri http://hdl.handle.net/11447/719
dc.identifier.uri http://dx.doi.org/10.1212/WNL.0000000000001205
dc.description.abstract OBJECTIVES: To investigate the effects of intensive blood pressure (BP) lowering according to baseline BP levels and optimal achieved BP levels in patients with acute intracerebral hemorrhage (ICH). METHODS: INTERACT2 was an open, blinded endpoint, randomized controlled trial in 2,839 patients with ICH within 6 hours of onset and elevated systolic BP (SBP) (150-220 mm Hg) who were allocated to receive intensive (target SBP <140 mm Hg within 1 hour, with lower limit of 130 mm Hg for treatment cessation) or guideline-recommended (target SBP <180 mm Hg) BP-lowering treatment. Outcome was physical function across all 7 levels of the modified Rankin Scale at 90 days. RESULTS: Analysis of the randomized comparisons showed that intensive BP lowering produced comparable benefits on physical function at 90 days in 5 subgroups defined by baseline SBP of <160, 160-169, 170-179, 180-189, and ≥190 mm Hg (p homogeneity = 0.790). Analyses of achieved BP showed linear increases in the risk of physical dysfunction for achieved SBP above 130 mm Hg for both hyperacute (1-24 hours) and acute (2-7 days) phases while modest increases were also observed for achieved SBP below 130 mm Hg. CONCLUSIONS: Intensive BP lowering appears beneficial across a wide range of baseline SBP levels, and target SBP level of 130-139 mm Hg is likely to provide maximum benefit in acute ICH.
dc.language.iso en_US
dc.publisher American Academy of Neurology
dc.subject Blood pressure
dc.subject Cerebral hemorrhage
dc.subject Antihypertensive agents
dc.title Optimal achieved blood pressure in acute intracerebral hemorrhage INTERACT2
dc.type Artículo


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