• Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study 

  Long, Georgina; Dummer, Reinhard; Hamid, Omid; Gajewski, Thomas; Caglevic, Christian; Dalle, Stephane; Arance, Ana; Carlino, Matteo; Grob, Jean-Jacques Grob; Kim, Tae; Demidov, Lev; Robert, Caroline; Larkin, James; Anderson, James; Maleski, Janet; Jones, Mark; Diede, Scott; Mitchell, Tara (Elsevier Ltd., 2019)

  Background: Immunotherapy combination treatments can improve patient outcomes. Epacadostat, an IDO1 selective inhibitor, and pembrolizumab, a PD-1 inhibitor, showed promising antitumour activity in the phase 1-2 ...
• Complete Sequence of the 22q11.2 Allele in 1,053 Subjects with 22q11.2 Deletion Syndrome Reveals Modifiers of Conotruncal Heart Defects 

  Zhao, Yingjie; Diacou, Alexander; Johnston, Richard; Musfee, Fadi; McDonald-McGinn, Donna; McGinn, Daniel; Crowley, Blaine; Repetto, Gabriela; Swillen, Ann; Breckpot, Jeroen; Vermeesch, Joris; Kates, Wendy; Digilio, Cristina; Unolt, Marta; Marino, Bruno; Pontillo, Maria; Armando, Marco; Di Fabio, Fabio; Vicari, Stefano; van den Bree, Marianne; Moss, Hayley; Owen, Michael; Murphy, Kieran; Murphy, Clodagh; Murphy, Declan; Schoch, Kelly; Shashi, Vandana; Tassone, Flora (American Society of Human Genetics by Elsevier Inc., 2020-01)

  The 22q11.2 deletion syndrome (22q11.2DS) results from non-allelic homologous recombination between low-copy repeats termed LCR22. About 60%-70% of individuals with the typical 3 megabase (Mb) deletion from LCR22A-D have ...
• Exosomes on the border of species and kingdom intercommunication 

  Schuh, Christina; Cuenca, Jimena; Alcayaga-Miranda, Francisca; Khoury, Maroun (2019-08)

  Over the last decades exosomes have become increasingly popular in the field of medicine. While until recently they were believed to be involved in the removal of obsolete particles from the cell, it is now known that ...
• Saccadic Direction Errors are Associated with Impulsive Compulsive Behaviours in Parkinson's Disease Patients 

  Barbosa, Pedro; Kaski, Diego; Castro, Patricia; Andrew, Andrew; Warner, Thomas; Djamshidian, Atbin (IOS Press, 2019)

  Fifteen individuals with Parkinson's disease (PD) and impulsive compulsive behaviours (PD+ICB) were compared to 15 PD patients without ICBs (PD-ICB) and 15 healthy controls (HC) on a pro-saccades and an anti-saccades task ...
• What Is the Significance of Variant Histology in Urothelial Carcinoma? 

  Lobo, Niyati; Shariat, Shahrokh; Guo, Charles; Fernández, Mario; Kassouf, Wassim; Choudhury, Ananya; Gao, Jianjun; Williams, Stephen; Galsky, Matthew; Taylor, John; Roupret, Morgan; Kamat, Ashish (European Association of Urology by Elsevier B.V, 2020-07)

  Context: Urothelial carcinoma can exhibit a wide range of variant morphologies. Many variants present diagnostic challenges and carry clinical implications that inform prognosis and treatment decisions. Objective: To ...
• Subjective stability perception is related to postural anxiety in older subjects 

  Castro, Patricia; Kaski, Diego; Schieppati, Marco; Furman, Michael; Arshad, Qadeer; Bronstein, Adolfo (Elsevier B.V., 2019-02)

  Background: Under static conditions, the objective and subjective measures of postural stability correlate well. However, age-related changes in postural control and task-related anxiety may modify the relationship between ...
• Sex differences in treatment and outcome after stroke: Pooled analysis including 19,000 participants 

  Carcel, Cheryl; Wang, Xia; Sandset, Else; Delcourt, Candice; Arima, Hisatomi; Lindley, Richard; Hackett, Maree; Lavados, Pablo; Robinson, Thompson; Muñoz-Venturelli, Paula; Olavarría, Verónica; Brunser, Alejandro; Berge, Eivind; Chalmers, John; Woodward, Mark; Anderson, Craig (American Academy of Neurology, 2019-12)

  Objective: To explore the sex differences in outcomes and management after stroke using a large sample with high-quality international trial data. Methods: Individual participant data were obtained from 5 acute stroke ...
• Targetable cellular signaling events mediate vascular pathology in vascular Ehlers-Danlos syndrome 

  Bowen, Caitlin; Calderón, Juan Francisco; Burger, Zachary; Rykiel, Graham; Davis, Elaine; Helmers, Mark; Benke, Kelly; Gallo, Elena; Dietz, Harry (American Society for Clinical Investigation., 2020-02)

  Vascular Ehlers-Danlos syndrome (vEDS) is an autosomal-dominant connective tissue disorder caused by heterozygous mutations in the COL3A1 gene, which encodes the pro-α 1 chain of collagen III. Loss of structural integrity ...
• Glucocorticoid Receptor-α and MKP-1 as Candidate Biomarkers for Treatment Response and Disease Activity in Vogt-Koyanagi-Harada Disease 

  Urzua, Cristhian; Chen, Ping; Chaigne-Delalande, Benjamin; Liu, Baoying; Anguita, Rodrigo; Guerrero, Julia; Sabat, Pablo; Velásquez, Víctor; Sen, Nida; Lee, Richard; Goecke, Annelise (Elsevier Inc, 2019-11)

  Purpose To investigate the potential of utilizing the expression of genes for glucocorticoid receptor (GR) and mitogen-activated protein kinase phosphatase-1 (MKP-1) as biomarkers of corticosteroid (CS) refractoriness and ...
• Laboratory exposure to Coccidioides: lessons learnt in a non-endemic country 

  Porte, Lorena; Valdivieso, Francisca; Wilmes, Dunja; Thompson, Luis; Munita, José; Varela, Carmen; Rickerts, Volker; Weitzel, Thomas; Gaete, P; Díaz, MC; Alliende, R (Elsevier Ltd, 2019-08)

  Coccidioides is a primary pathogenic fungus, which infects humans through highly infectious arthroconidia, causing substantial morbidity including life-threatening disseminated infections. Due to the low infectious dose, ...
• Shortage of yellow fever vaccination: A travel medicine emergency for Chilean travellers 

  Weitzel, Thomas; Vial, Pablo; Perret, Cecilia; Aguilera, Ximena (Elsevier Ltd., 2019-03)

  In recent years, yellow fever (YF) outbreaks have struck various African and South American countries, a scenario, which led to the creation of the “Eliminate Yellow fever Epidemics” initiative by the WHO [1]. The current ...
• Impact of arsenic exposure on clinicopathological characteristics of bladder cancer: A comparative study between patients from an arsenic-exposed region and nonexposed reference sites 

  Fernández, Mario; Valdebenito, Patricio; Delgado, Iris; Segebre, Jorge; Chaparro, Eduardo; Fuentealba, David; Castillo, Martín; Vial, Cecilia; Barroso, Juan; Ziegler, Annemarie; Bustamante, Alberto (Elsevier Inc., 2020-02)

  Background: Beyond exposure to arsenic in drinking-water, there is few information about demographic and clinicopathological features of patients with bladder cancer living in arsenic-exposed regions. The aim of the study ...
• Impact of anthropometric nutritional parameters on the university selection test in Chile: A multifactorial approach 

  Ivanovic, Daniza; Valenzuela, Rodrigo; Almagia, Atilio; Barrera, Cynthia; Arancibia, Violeta; Larraín, Cristian; Silva, Claudio; Billeke, Pablo; Zamorano, Francisco; Villagrán, Francisca; Orellana, Yasna; Martínez, Víctor (Elsevier Inc., 2019-01)

  Objectives Scholastic achievement (SA) is a multifactorial problem that depends on factors related to the child, the child's family, and the educational system. The aim of this study was to quantify the relative impact ...
• Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry 

  Carvajal-Hausdorf, Daniel; Patsenker, Jonathan; Stanton, Kelly; Villarroel-Espindola, Franz; Esch, Amanda; Montgomery, Montgomery; Psyrri, Amanda; Kalogeras, Konstantine; Kotoula, Vassiliki; Foutzilas, George; Schalper, Kurt; Kluger, Yuval; Rimm, David (American Association for Cancer Research., 2019-05)

  Purpose: Imaging mass cytometry (IMC) uses metal-conjugated antibodies to provide multidimensional, objective measurement of protein targets. We used this high-throughput platform to perform an 18-plex assessment of HER2 ...
• Immune Checkpoint Inhibitor-Associated Pericarditis 

  Altan, Mehmet; Toki, Maria; Gettinger, Scott; Carvajal-Hausdorf, Daniel; Zugazagoitia, Jon; Sinard, John; Herbst, Roy; Rimm, David (Elsevier Inc., 2019-06)

  Side effects of immune checkpoint inhibitors, termed immune-related adverse events, are relatively common, but immune checkpoint inhibitor-mediated cardiotoxicities are rare; however, they can be serious and potentially ...
• Predictors of unmet needs in Chilean older people with dementia: a cross-sectional study 

  Tapia-Muñoz, Thamara; Slachevsky, Andrea; León-Campos, María; Madrid, Michel; Caqueo-Urizar, Alejandra; Rohde, Gustav; Miranda-Castillo, Claudia (BioMed Central Ltd, 2019-04)

  Background The needs of people with dementia (PWD) have not been assessed in any Latin American country. Several European countries have already related unmet needs with quality of life, caregiver’s age, burden, stress, ...
• Mapping the neuroanatomy of functional decline in Alzheimer's disease from basic to advanced activities of daily living 

  Slachevsky, Andrea; Forno, Gonzalo; Barraza, Paulo; Mioshi, Eneida; Delgado, Carolina; Lillo, Patricia; Henríquez, Fernando; Bravo, Eduardo; Farias, Mauricio; Muñoz-Neira, Carlos; Ibáñez, Agustín; Parra, Mario; Hornberger, Michael (Springer Nature, 2019-06)

  Background: Impairments in activities of daily living (ADL) are a criterion for Alzheimer's disease (AD) dementia. However, ADL gradually decline in AD, impacting on advanced (a-ADL, complex interpersonal or social ...
• Fronto-Subcortical Circuits for Cognition and Motivation: Dissociated Recovery in a Case of Loss of Psychic Self-Activation 

  Riveros, Rodrigo; Bakchine, Serge; Pillon, Bernard; Poupon, Fabrice; Miranda, Marcelo; Slachevsky, Andrea (Frontiers Ed., 2019-01)

  In humans and non-humans primates, extensive evidence supports the existence of subcortico-cortical circuits for cognition and behavior. Lesions studies are critical to understand the clinical significance of these ...
• Clinical, Biochemical, and Genetic Characteristics of “Nonclassic” Apparent Mineralocorticoid Excess Syndrome 

  Tapia-Castillo, Alejandra; Baudrand, Rene; Vaidya, Anand; Campino, Carmen; Allende, Fidel; Valdivia, Carolina; Vecchiola, Andrea; Lagos, Carlos; Fuentes, Cristóbal; Solari, Sandra; Martínez-Aguayo, Alejandro; García, Hernán; Carvajal, Cristian; Fardella, Carlos (Oxford University Press, 2018-09)

  Context Classical apparent mineralocorticoid excess (AME) is a rare recessive disorder, caused by severe 11β-hydroxysteroid dehydrogenase type 2 enzyme (11β-HSD2) deficiency. AME manifests as low-renin pediatric hypertension, ...
• Surfactant-mediated enzymatic superactivity in water/ionic liquid mixtures, evaluated on a model hydrolytic reaction catalyzed by α-chymotrypsin 

  Calderón, Cristian; Contreras, Renato; Campodónico, Paola (Elsevier B.V., 2019-06)

  In this work, the influence of the C12-, C14-, and C16-alkyl chain derivatives of 1-alkyl-3-methyl-imidazole tetrafluoroborate over the hydrolisis of p-nitrophenyl trimethylacetate catalyzed by α-chymotrypsin was studied ...

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