• Aspirin and N‐acetylcysteine co‐administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation‐oxidative stress self‐perpetuation 

  Israel, Yedy; Quintanilla, María Elena; Ezquer, Fernando; Morales, Paola; Santapau, Daniela; Berríos-Cárcamo, Pablo; Ezquer, Marcelo; Olivares, Belen; Herrera-Marschitz, Mario (2020)

  Chronic alcohol intake leads to neuroinflammation and cell injury, proposed to result in alterations that perpetuate alcohol intake and cued-relapse. Studies show that brain oxidative stress is consistently associated with ...
• Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking. 

  Ezquer, Fernando; Quintanilla, María Elena; Morales, Paola; Santapau, Daniela; Ezquer, Marcelo; Kogan, Marcelo J.; Salas-Huenuleo, Edison; Herrera-Marschitz, Mario; Israel, Yedy (2020)

  Chronic ethanol consumption leads to brain oxidative stress and neuroinflammation, conditions known to potentiate and perpetuate each other. Several studies have shown that neuroinflammation results in increases in chronic ...
• Gene and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational options 

  Israel, Yedy; Quintanilla, María Elena; Ezquer, Fernando; Morales, Paola; Rivera-Meza, Mario; Karahanian, Eduardo; Ezquer, Marcelo; Herrera-Marschitz, Mario (2020)

  Studies reviewed show that lentiviral gene therapy directed either at inhibiting the synthesis of brain acetaldehyde generated from ethanol or at degrading brain acetaldehyde fully prevent ethanol intake by rats bred for ...
• Intranasal mesenchymal stem cell secretome administration markedly inhibits alcohol and nicotine self-administration and blocks relapse-intake: mechanism and translational options 

  Quintanilla, María Elena; Ezquer, Fernando; Morales, Paola; Santapau, Daniela; Berríos-Cárcamo, Pablo; Ezquer, Marcelo; Herrera-Marschitz, Mario; Israel, Yedy (2019)

  Background: Chronic consumption of most drugs of abuse leads to brain oxidative stress and neuroinflammation, which inhibit the glutamate transporter GLT-1, proposed to perpetuate drug intake. The present study aimed at ...
• Identification of Rigosertib for the Treatment of Recessive Dystrophic Epidermolysis Bullosa-Associated Squamous Cell Carcinoma. 

  Atanasova, Velina S.; Pourreyron, Celine; Farshchian, Mehdi; Christian A., Brown IV; Watt, Stephen A.; Wright, Sheila; Warkala, Michael; Guttmann-Gruber, Christina; Piñón Hofbauer, Josefina; Fuentes, Ignacia; Prisco, Marco; Rashidghamat, Elham; Has, Cristina; Palisson, Francis; Hovnanian, Alain; McGrath, John A.; Mellerio, Jemima E.; Bauer, Johann; South, Andrew P. (2019)

  Purpose: Squamous cell carcinoma (SCC) of the skin is the leading cause of death in patients with the severe generalized form of the genetic disease recessive dystrophic epidermolysis bullosa (RDEB). Although emerging data ...
• Deletions in Genes Participating in Innate Immune Response Modify the Clinical Course of Andes Orthohantavirus Infection 

  Ribeiro E., Grazielle; Luis Edgardo, Leon; Perez, Ruth; Cuiza V., Analia; Vial, Pablo; Ferres, Marcela; Mertz, Gregory J.; Vial, Cecilia (2019)

  Andes orthohantavirus (ANDV) is an important human pathogen causing hantavirus cardiopulmonary syndrome (HCPS) with a fatality rate of 30% in Chile. Around 60% of all cases have a severe clinical course, while the others ...
• A Single-Nucleotide Polymorphism of αVβ3 Integrin Is Associated with the Andes Virus Infection Susceptibility 

  Martínez-Valdebenito, Constanza; Angulo, Jenniffer; Corre, Nicole Le; Marco, Claudia; Vial, Cecilia; Miquel, Juan Francisco; Cerda, Jaime; Mertz, Gregory; Vial, Pablo; Lopez-Lastra, Marcelo; Ferrés, Marcela (2019)

  The Andes Orthohantavirus (ANDV), which causes the hantavirus cardiopulmonary syndrome, enters cells via integrins, and a change from leucine to proline at residue 33 in the PSI domain (L33P), impairs ANDV recognition. ...
• Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation 

  Hoste, Esther; Maueröder, Christian; Hove, Lisette van; Catrysse, Leen; Vikkula, Hanna-Kaiza; Sze, Mozes; Maes, Bastiaan; Karjosukarso, Dyah; Martens, Liesbet; Goncalves, Amanda; Parthoens, Eef; Roelandt, Ria; Declercq, Wim; Fuentes, Ignacia; Palisson, Francis; Gonzalez, Sergio; Salas-Alanis, Julio C.; Boon, Louis; Huebener, Peter; Mulder, Klaas Willem; Ravichandran, Kodi; Saeys, Yvan; Schwabe, Robert Felix; Loo, Geert van (2019)

  Regenerative responses predispose tissues to tumor formation by largely unknown mechanisms. High-mobility group box 1 (HMGB1) is a dangerassociated molecular pattern contributing to inflammatory pathologies. We show that ...
• Epidermolysis bullosa simplex-generalized severe due to p.Glu477Lys mutation in keratin 5: a genotype-phenotype correlation with in silico modeling analysis 

  Lalor, Leah; Titeux, Matthias; Palisson, Francis; Fuentes, Ignacia; Yubero, María; Tasanen, Kaisa; Huilaja, Laura; Has, Cristina; Tadini, Gianluca; Haggstrom, Anita N.; Hovnanian, Alain; Lucky, Anne W. (2019)

  Background/Objectives: Epidermolysis bullosa is a group of diseases caused by mutations in skin structural proteins. Availability of genetic sequencing makes identification of causative mutations easier, and genotype‐phenotype ...
• Epidermolysis bullosa simplex with KLHL24 mutations is associated with dilated cardiomyopathy 

  Schwieger-Briel, A.; Fuentes, Ignacia; Castiglia, D.; Barbato, A.; Greutmann, M.; Leppert, J.; Duchatelet, S.; Hovnanian, A.; Burattini, S.; Yubero, María; Ibañez-Arenas, Rodrigo; Rebolledo-Jaramillo, B.; Gräni, C.; Ott, H.; Theiler, M.; Weibel, L.; Paller, A.S.; Zambruno, G.; Fischer, J.; Palisson, Francis; Has, C. (2019)

  Inherited epidermolysis bullosa (EB) comprises rare heterogeneous disorders characterized by cutaneous and mucosal fragility. Most of the 20 proteins affected have structural functions. Recently, a previously undescribed ...
• Resección hepática extendida con vena cava inferior por colangiocarcinoma intrahepático. Presentación de 2 casos 

  Rencoret, Guillermo; Vivanco, Marcelo; Castillo, Felipe; Schiappacasse, Giancarlo; de Aretxabala, Xabier; Bianchi, Víctor; Hepp, Juan; Ríos, Horacio (2019)

  Introduction: Intrahepatic cholangiocarcinoma is the second most common primary liver tumor and surgical resection the only valid curative treatment. Case reports: We describe two patients harboring an intrahepatic ...
• Proximal and Distal Failure Site Analysis in Percutaneous Achilles Tendon Rupture Repair 

  Wagner, Pablo; Wagner, Emilio; López, M.; Etchevers, G.; Valencia, O.; Guzmán-Venegas, R. (2019)

  Background: Different techniques have been described for percutaneous Achilles tendon rupture repair, but no biomechanical evaluation has been performed separately for proximal and distal suturing techniques. The purpose ...
• Clinical Practice Guidelines for Epidermolysis Bullosa Laboratory Diagnosis 

  Has, Cristina; Liu, Lu; Bolling, Marieke; Charlesworth, Alexandra V.; Hachem, May El; Escámez, María José; Fuentes, Ignacia; Büche, Sarah; Hiremagalore, Ravi; Pohla-Gubo, Gabriele; Akker, Peter van den; Wertheim-Tysarowska, Katarzyna; Zambruno, Giovanna (2019)

  The overall objective of this guideline is to provide the user with information on the laboratory diagnosis of inherited epidermolysis bullosa (EB) to improve outcomes (Table 1). An accurate diagnosis and subclassification ...
• Achilles tendoscopy for non insertional achilles tendinopathy. A preliminary study 

  Wagner, Pablo; Wagner, Emilio; Ortiz, C.; Zanolli, Diego; Keller, A.; Maffulli, N. (2019)

  Background: To report the mid-term clinical results of endoscopic assisted surgery for patients suffering from chronic recalcitrant painful mid-portion Achilles tendinopathy who failed conservative management for at least ...
• Dietary Patterns of Breakfast Consumption Among Chilean University Students 

  Díaz-Torrente, Ximena; Quintiliano-Scarpelli, Daiana (2019)

  Breakfast is one of the most important meals of the day. A good quality breakfast must include dairy products, cereals, and fruits. The aim of this study is to determine breakfast dietary patterns and their nutritional ...
• Factores de riesgo socio-demográficos del síndrome cardiopulmonar por hantavirus 

  Vial, Cecilia; Valdivieso, Francisca; Cuiza V., Analía; Delgado B., Iris; Ribeiro E., Grazielle; Llop R., Elena; Ferrés G., Marcela; Repetto, Gabriela; Riquelme O., Raúl; Rioseco Z., M. Luisa; Calvo A., Mario; Mertz, Gregory; Vial, Pablo (2019)

  Background: Hantavirus cardiopulmonary syndrome (HCPS) is caused by new world hantaviruses, among which Andes hantavirus (ANDV) is endemic to Chile and Southern Argentina. The disease caused by ANDV produces plasma leakage ...
• Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma 

  Rosenberger, Leonie; Ezquer, Marcelo; Lillo-Vera, Fernando; Pedraza, Paulina L.; Ortúzar, María Ignacia; González, Paz L.; Figueroa-Valdés, Aliosha I.; Cuenca, Jimena; Ezquer, Fernando; Khoury, Maroun; Alcayaga-Miranda, Francisca (2019)

  Recently, exosomes secreted by menstrual mesenchymal stem cells have been identified as inhibitory agents of tumor angiogenesis and modulators of the tumor cell secretome in prostate and breast cancer. However, their direct ...
• Scrub Typhus in Continental Chile, 2016-2018 1 

  Weitzel, Thomas; Martínez-Valdebenito, Constanza; Acosta-Jamett, Gerardo; Jiang, Ju; Richards, Allen; Abarca, Katia (National Center for Infectious Diseases, 2019)

  Endemic scrub typhus was recently detected on Chiloé Island in southern Chile. We report a series of cases, acquired over a wide geographical range in continental Chile during 2016-2018, demonstrating that this emerging ...
• Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant breast cancer cells. 

  Lobos-González, Lorena; Bustos, Rocío; Campos, América; Silva, Valeria; Silva, Verónica; Jeldes, Emanuel; Salomon, Carlos; Varas-Godoy, Manuel; Cáceres-Verschae, Albano; Durán, Eduardo; Vera, Tamara; Ezquer, Fernando; Ezquer, Marcelo; Burzio, Verónica; Villegas, Jaime (Nature Publishing Group, 2020)

  During intercellular communication, cells release extracellular vesicles such as exosomes, which contain proteins, ncRNAs and mRNAs that can influence proliferation and/or trigger apoptosis in recipient cells, and have ...
• Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation 

  Arce, Maximiliano; Pinto, Mauricio; Galleguillos, Macarena; Muñoz, Catalina; Lange, Soledad; Ramirez, Carolina; Erices, Rafaela; González, Pamela; Velásquez, Ethel; Tempio, Fabián; López, Mercedes; Salazar-Onfray, Flavio; Cautivo, Kelly; Kalergis, Alexis; Cruz, Sebastián; Lorena Lobos-González, Lorena Lobos-González; Lladser, Álvaro; Lobos-González, Lorena; Valenzuela, Guillermo; Olivares, Nixa; Sáez, Claudia; Koning, Tania; Sánchez, Fabiola; Fuenzalida, Patricia; Godoy, Alejandro; Contreras, Pamela; Leyton, Lisette; Lugano, Roberta; Dimberg, Anna; Quest, Andrew; Owen, Gareth (Multidisciplinary Digital Publishing Institute (MDPI), 2019)

  Hypercoagulable state is linked to cancer progression; however, the precise role of the coagulation cascade is poorly described. Herein, we examined the contribution of a hypercoagulative state through the administration ...

View more