• Mother-to-Child Transmission of Andes Virus through Breast Milk, Chile 

  Ferrés, Marcela; Martínez-Valdebenito, Constanza; Angulo, Jenniffer; Henríquez, Carolina; Vera-Otaróla, Jorge; Vergara, María José; Pérez, Javier; Fernández, Jorge; Sotomayor, Viviana; Valdés, María Francisca; González-Candia, Diego; Tischler, Nicole D.; Vial, Cecilia; Vial, Pablo; Mertz, Gregory; Le Corre, Nicole (2020-08)

  Andes virus (ANDV) is the only hantavirus transmitted between humans through close contact. We detected the genome and proteins of ANDV in breast milk cells from an infected mother in Chile who transmitted the virus to her ...
• Comparison of Suture-Augmented Ligamentplasty to Transarticular Screws in a Lisfranc Cadaveric Model 

  Nery, Caio; Baumfeld, Daniel; Baumfeld, Tiago; Prado, Marcelo; Giza, Eric; Wagner, Pablo; Wagner, Emilio (2020)

  Background: Lisfranc injuries represent a spectrum of trauma from high-energy lesions, with significant instability of the midfoot, to low-energy lesions, with subtle subluxations or instability without gross displacement. ...
• N-Acetylcysteine and Acetylsalicylic Acid Inhibit Alcohol Consumption by Different Mechanisms: Combined Protection 

  Quintanilla, María Elena; Ezquer, Fernando; Morales, Paola; Ezquer, Marcelo; Olivares, Belen; Santapau, Daniela; Herrera-Marschitz, Mario; Israel, Yedy (2020-07)

  Chronic ethanol intake results in brain oxidative stress and neuroinflammation, which have been postulated to perpetuate alcohol intake and to induce alcohol relapse. The present study assessed the mechanisms involved in ...
• Comparison of VSV Pseudovirus and Focus Reduction Neutralization Assays for Measurement of Anti-Andes orthohantavirus Neutralizing Antibodies in Patient Samples 

  Vial, Cecilia; Whitaker, Annalis; Wilhelm, Jan; Ovalle, Jimena; Perez, Ruth; Valdivieso, Francisca; Ferres, Marcela; Martínez-Valdebenito, Constanza; Eisenhauer, Philip; Mertz, Gregory J.; Hooper, Jay W.; Botten, Jason W.; Vial, Pablo (2020-09)

  Andes orthohantavirus (ANDV) is the etiologic agent of hantavirus cardiopulmonary syndrome (HCPS), which has a case fatality rate around 35%, with no effective treatment or vaccine available. ANDV neutralizing antibody ...
• Experimental Analyses Emphasize the Stability of the Meisenheimer Complex in a S N Ar Reaction Toward Trends in Reaction Pathways 

  Campodónico, Paola; Olivares, Belén; Tapia, Ricardo A. (2020-07)

  The mechanism of SNAr reactions between 2-chloro-5-nitropyrimidine with primary and secondary alicyclic amines, respectively, have been studied by kinetic measurements. The kinetic data obtained in aqueous media opens a ...
• Heterogeneity Among Poor Ovarian Responders According to Bologna Criteria Results in Diverging Cumulative Live Birth Rates 

  Romito, Alessia; Errázuriz, Joaquín; Bardhi, Erlisa; Blockeel, Christophe; Santos-Ribeiro, Samuel; De Vos, Michel; Racca, Annalisa; Mackens, Shari; Benedetti Panici, Pierluigi; Vaiarelli, Alberto; Tournaye, Herman; Drakopoulos, Panagiotis; Van Der Kelen, Annelore; Alessia Romito 1 2, Erlisa Bardhi 1 2, Joaquin Errazuriz 3, Christophe Blockeel 1 4, Samuel Santos-Ribeiro 5, Michel De Vos 1, Annalisa Racca 1, Shari Mackens 1, Annelore Van Der Kelen 1, Pierluigi Benedett (2020-04)

  Research Question: Does reproductive outcome differ among the various subgroups of poor ovarian responders according to the Bologna criteria? Design: This was a retrospective, cohort study including poor ovarian responders ...
• New Pharmacological Strategies for the Treatment of Non-Infectious Uveitis. A Minireview 

  Valenzuela, Rodrigo A.; Flores, Iván; Urrutia, Beatríz; Fuentes, Francisca; Sabat, Pablo E.; Llanos, Carolina; Cuitino, Loreto; Urzua, Cristhian (2020-05)

  Non-infectious uveitis (NIU) is a group of disorders characterized by intraocular inflammation at different levels of the eye. NIU is a leading cause of irreversible blindness in working-age population in the developed ...
• First Report of Tocilizumab Use in a Cohort of Latin American Patients Hospitalized for Severe COVID-19 Pneumonia 

  Valenzuela, Omar; Ibáñez, Sebastián; Poli, Cecilia; Roessler, Patricia; Aylwin, Mabel; Roizen, Gigia; Iruretagoyena, Mirentxu; Agar, Vivianne; Donoso, Javiera; Fierro, Margarita; Montes, José (2020)

  Introduction/objectives: An interleukin-6 inhibition strategy could be effective in selected COVID-19 patients. The objective is to present our experience of tocilizumab use in patients with severe COVID-19. Methods: ...
• Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation 

  Alfaro, Iván; Ormeño, Fernando; Hormazabal, Juan; Moreno, José; Riquelme, Felipe; Ríos, Javiera; Criollo, Alfredo; Albornoz, Amelina; Budini, Mauricio (2020)

  TAR DNA binding protein 43 kDa (TDP-43) is a ribonuclear protein regulating many aspects of RNA metabolism. Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD) are fatal neurodegenerative ...
• Role of ROS/RNS in Preeclampsia: Are Connexins the Missing Piece? 

  Rozas, M. Fernanda; Casanello, Paola; Retamal, Mauricio (2020)

  Preeclampsia is a pregnancy complication that appears after 20 weeks of gestation and is characterized by hypertension and proteinuria, affecting both mother and offspring. The cellular and molecular mechanisms that cause ...
• Attention deficit hyperactivity disorder and its association with heavy metals in children from northern Chile 

  Muñoz, María Pía; Rubilar, Paola; Valdés, Macarena; Muñoz-Quezada, María Teresa; Gómez, Andrea; Saavedra, Marta; Iglesias, Verónica (2020)

  Introduction: Exposure to lead and arsenic has been associated with child behavior problems. In Arica, a northern city of Chile, the natural presence of arsenic in water has been registered. Also, the city has a history ...
• Helicobacter pylori, clinical, laboratory, and noninvasive biomarkers suggestive of gastric damage in healthy school-aged children: A case-control study 

  Lucero, Yalda; Lagomarcino, Anne J.; Torres, Juan P; Roessler, Patricia; Mamani, Nora; George, Sergio; Huerta, Nicole; Gonzalez, Mónica; O'Ryan, Miguel (2020)

  Background: Helicobacter pylori is acquired largely in early childhood, but its association with symptoms and indirect biomarkers of gastric damage in apparently healthy children remains controversial. We aimed to relate ...
• Evaluation of a novel antigen-based rapid detection test for the diagnosis of SARS-CoV-2 in respiratory samples 

  Porte, Lorena; Legarraga, Paulette; Vollrath, V.; Aguilera, Ximena; Munita, Jose; Araos, Rafael; Pizarro, Gabriel; Vial, Pablo; Iruretagoyena, Mirentxu; Dittrich, Sabine; Weitzel, Thomas (2020)

  Objectives: In the context of the coronavirus disease 2019 (COVID-19) pandemic, the development and validation of rapid and easy-to-perform diagnostic methods are of high priority. This study was performed to evaluate a ...
• Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia 

  Farfán, Nancy; Carril, Jaime; Redel, Martina; Zamorano, Marta; Araya, Maureen; Monzón, Estephania; Alvarado, Raúl; Contreras, Norton; Tapia-Bustos, Andrea; Quintanilla, María Elena; Ezquer, Fernando; Valdés, José Luis; Israel, Yedy; Herrera-Marschitz, Mario; Morales, Paola (2020)

  Perinatal Asphyxia (PA) is a leading cause of motor and neuropsychiatric disability associated with sustained oxidative stress, neuroinflammation, and cell death, affecting brain development. Based on a rat model of global ...
• NGF/TRKA Decrease miR-145-5p Levels in Epithelial Ovarian Cancer Cells 

  Garrido, Maritza P.; Torres, Ignacio; Avila, Alba; Chnaiderman, Jonás; Valenzuela-Valderrama, Manuel; Aramburo, José; Oróstica, Lorena; Duran, Eduardo; Lobos-González, Lorena; Romero, Carmen (2020)

  Nerve Growth Factor (NGF) and its high-affinity receptor tropomyosin receptor kinase A (TRKA) increase their expression during the progression of epithelial ovarian cancer (EOC), promoting cell proliferation and angiogenesis ...
• Treponematosis in a pre-Columbian hunter-gatherer male from Antofagasta (1830 ± 20 BP, Northern Coast of Chile) 

  Castro, Mario; Pacheco, Aryel; Kuzmanic, Ivo; Clarot, Alejandro; Díaz, Pablo (2020)

  Objective: This paper reports a new case of treponemal disease in a pre-Columbian hunter-gatherer inhabiting the desert coast of South America. Materials: A well-preserved adult male skeleton from the “Vertedero Municipal” ...
• Metatarsal Pronation in Hallux Valgus Deformity: A Review 

  Wagner, Emilio; Wagner, Pablo (2020)

  Hallux valgus deformity is a multiplanar deformity, where the rotational component has been recognized over the past 5 to 10 years and given considerable importance. Years ago, a rounded shape of the lateral edge of the ...
• Norovirus compared to other relevant etiologies of acute gastroenteritis among families from a semirural county in Chile 

  Lucero, Yalda; Lagomarcino, Anne J.; Espinoza, Mónica; Kawakami, Nanami; Mamani, Nora; Huerta, Nicole; Canto, Felipe del; Farfán, Mauricio; Sawaguchi, Yoshihiro; George, Sergio; O’Ryan, Miguel (2020)

  Objective: To determine the dynamics of norovirus disease, a major cause of acute gastroenteritis (AGE), compared to other relevant etiologies, among families living in a lower middle income area. Study design :Families ...
• Connexin-46 Contained in Extracellular Vesicles Enhance Malignancy Features in Breast Cancer Cells 

  Acuña, Rodrigo; Varas-Godoy, Manuel; Berthoud, Viviana M.; Alfaro, Iván; Retamal, Retamal, Mauricio (2020)

  Under normal conditions, almost all cell types communicate with their neighboring cells through gap junction channels (GJC), facilitating cellular and tissue homeostasis. A GJC is formed by the interaction of two hemichannels; ...
• Covid-19 in South America: clinical and epidemiological characteristics among 381 patients during the early phase of the pandemic in Santiago, Chile 

  Vial, Macarena; Peters, Anne; Pérez, Inia; Spencer-Sandino, María; Barbé, Mario; Porte, Lorena; Weitzel, Thomas; Aylwin, Mabel; Vial, Pablo; Araos, Rafael; Munita, Jose (2020)

  Background: Understanding the characteristics of the Covid-19 pandemic in different geographical regions, ethnic and socioeconomic settings are of emerging importance. This study presents the demographic and clinical ...

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