• Evaluation of the effectiveness and equity of the maternity protection reform in Chile from 2000 to 2015 

  Delgado, Iris; Cabieses, Báltica; Apablaza, Mauricio; Castillo, Carla; Aguilera, Ximena; Matute, Isabel; Najera, Manuel; Pericás, Juan M.; Benach, Joan (2019)

  Introduction According to the International Labor Organization, Maternity Protection (MP) policies try to harmonize child care and women’s paid work, without affecting family health and economic security. Chile Law 20.545 ...
• Streamlined computational pipeline for genetic background characterization of genetically engineered mice based on next generation sequencing data 

  Farkas, C.; Fuentes-Villalobos, F.; Rebolledo-Jaramillo, Boris; Benavides, F.; Castro, A.F.; Pincheira, R. (2019)

  Background: Genetically engineered mice (GEM) are essential tools for understanding gene function and disease modeling. Historically, gene targeting was first done in embryonic stem cells (ESCs) derived from the 129 family ...
• Association between phenotype and deletion size in 22q11.2 microdeletion syndrome: systematic review and meta-analysis 

  Rozas, M.Fernanda; Benavides, Felipe; León, Luis; Repetto, Gabriela (2019)

  Background: Chromosome 22q11.2 microdeletion syndrome, a disorder caused by heterozygous loss of genetic material in chromosome region 22q11.2, has a broad range of clinical symptoms. The most common congenital anomalies ...
• Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior 

  Gokhale, Avanti; Hartwig, Cortnie; Freeman, Amanda A.H.; Bassell, Julia L.; Zlatic, Stephanie A.; Sapp Savas, Christie; Vadlamudi, Trishna; Abudulai, Farida; Pham, Tyler T.; Crocker, Amanda; Werner, Erica; Wen, Zhexing; Repetto, Gabriela M.; Gogos, Joseph A.; Claypool, Steven M.; Forsyth, Jennifer K.; Bearden, Carrie E.; Glausier, Jill; Lewis, David A.; Seyfried, Nicholas T.; Kwong, Jennifer Q.; Faúndez, Víctor (2019)

  Neurodevelopmental disorders offer insight into synaptic mechanisms. To unbiasedly uncover these mechanisms, we studied the 22q11.2 syndrome, a recurrent copy number variant, which is the highest schizophrenia genetic risk ...
• Contribution of Connexin Hemichannels to the Decreases in Cell Viability Induced by Linoleic Acid in the Human Lens Epithelial Cells (HLE-B3) 

  Figueroa, Vania A.; Jara, Oscar; Oliva, Carolina A.; Ezquer, Marcelo; Ezquer, Fernando; Retamal, Mauricio; Martínez, Agustín D.; Altenberg, Guillermo A.; Vargas, Aníbal (2019)

  Connexin (Cx) proteins form hemichannels that a allow bidirectional flow of ions and metabolites between the cytoplasm and extracellular space. Under physiological conditions, hemichannels have a very low probability of ...
• Spatiotemporal differences in gene expression between motor and sensory autografts and their effect on femoral nerve regeneration in the rat 

  Hercher, David; Kerbl, Markus; Schuh, Christina; Heinzel, Johannes; Gal, László; Stainer, Michaela; Schmidhammer, Robert; Hausner, Thomas; Redl, Heinz; Nógrádi, Antal; Hacobian, Ara (2019)

  To improve the outcome after autologous nerve grafting in the clinic, it is important to understand the limiting variables such as distinct phenotypes of motor and sensory Schwann cells. This study investigated the ...
• Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging 

  Díaz-García, Víctor Manuel; Guerrero, Simón; Díaz-Valdivia, Natalia; Lobos-González, Lorena; Kogan, Marcelo; Pérez-Donoso, José Manuel.; Quest, Andrew F.G. (2018)

  Background: Numerous studies have proposed the use of fluorescent semiconductor nanoparticles or quantum dots (QDs) as novel tools to label cells and tumors. However, QD applications are limited by their toxicity in ...
• Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors 

  Fitzpatrick, Christopher; Bendek, Maximiliano F.; Briones, Macarena; Farfán, Nicole; Silva, Valeria A.; Nardocci, Gino; Montecino, Martín; Boland, Anne; Deleuze, Jean-Francois; Villegas, Jaime; Villota, Claudio; Silva, Verónica; Lobos-González, Lorena; Borgna, Vincenzo; Barrey, Eric; Burzio, Luis O.; Burzio, Verónica A. (2019)

  The family of long noncoding mitochondrial RNAs (ncmtRNAs), comprising sense (SncmtRNA), and antisense (ASncmtRNA-1 and ASncmtRNA-2) members, are differentially expressed according to cell proliferative status; SncmtRNA ...
• Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation 

  Arce, Maximiliano; Pinto, Mauricio P.; Galleguillos, Macarena; Muñoz, Catalina; Lange, Soledad; Ramírez, Carolina; Erices, Rafaela; González, Pamela; Velasquez, Ethel; Tempio, Fabián; López, Mercedes N.; Salazar-Onfray, Flavio; Cautivo, Kelly; Kalergis, Alexis M.; Cruz, Sebastián; Lladser, Álvaro; Lobos-González, Lorena; Valenzuela, Guillermo; Olivares, Nixa; Sáez, Claudia; Koning, Tania; Sánchez, Fabiola A.; Fuenzalida, Patricia; Godoy, Alejandro; Contreras Orellana, Pamela; Leyton, Lisette; Lugano, Roberta; Dimberg, Anna; Quest, A.F.G.; Owen, Gareth I. (2019)

  Hypercoagulable state is linked to cancer progression; however, the precise role of the coagulation cascade is poorly described. Herein, we examined the contribution of a hypercoagulative state through the administration ...
• Cell Intrinsic and Extrinsic Mechanisms of Caveolin- 1-Enhanced Metastasis 

  Campos, América; Burgos-Ravanal, R.; González, M.F.; Huilcamán, R.; Lobos-González, Lorena; Quest, AFG. (2019)

  Caveolin-1 (CAV1) is a scaffolding protein with a controversial role in cancer. This review will initially discuss earlier studies focused on the role as a tumor suppressor before elaborating subsequently on those relating ...
• Impact of Evidence-Based Stroke Care on Patient Outcomes: A Multilevel Analysis of an International study 

  Muñoz Venturelli, Paula; Li, Xian; Middleton, Sandy; Watkins, Caroline; Lavados, Pablo M.; Olavarría, Verónica; Brunser, Alejandro; Pontes-Neto, Octavio; Santos, Taiza; Hisatomi, Arima; Billot, Laurent; Hackett, Maree; Song, Lily; Robinson, Thompson; Anderson, Craig; HEADPOST, Head positioning in acute (2019)

  Background-—The uptake of proven stroke treatments varies widely. We aimed to determine the association of evidence-based processes of care for acute ischemic stroke (AIS) and clinical outcome of patients who participated ...
• Exosome-like vesicles in Apis mellifera bee pollen, honey and royal jelly contribute to their antibacterial and pro-regenerative activity 

  Schuh, Christina; Aguayo, Sebastian; Zavala, Gabriela; Khoury, Maroun (2019)

  Microvesicles are key players in cellular communication. As glandular secretions present a rich source of active exosomes, we hypothesized that exosome-like vesicles are present in Apis mellifera hypopharyngeal gland ...
• Potential novel strategies for the treatment of dental pulp-derived pain: pharmacological approaches and beyond 

  Schuh, Christina; Benso, Bruna; Aguayo, Sebastian (2019)

  The diagnosis and management of pain is an everyday occurrence in dentistry, and its effective control is essential to ensure the wellbeing of patients. Most tooth-associated pain originates from the dental pulp, a highly ...
• Adaptation to Extreme Environments in an Admixed Human Population from the Atacama Desert 

  Vicuña, Lucas; Fernández, Mario; Vial, Cecilia; Valdebenito, Patricio; Chaparro, Eduardo; Espinoza, Karena; Ziegler, Annmarie; Bustamante, Alberto; Eyheramendy, Susana (2019)

  Inorganic arsenic (As) is a toxic xenobiotic and carcinogen associated with severe health conditions. The urban population from the Atacama Desert in northern Chile was exposed to extremely high As levels(upto600 mg/l)in ...
• A 19 Year Analysis of Small Mammals Associated with Human Hantavirus Cases in Chile 

  Torrez-Pérez, Fernando; Palma, Eduardo; Boric-Bargetto, Dusan; Vial, Cecilia; Ferrés, Marcela; Vial, Pablo; Martínez-Valdebenito, Constanza; Pavletic, Carlos; Parra, Alonso; Marquet, Pablo; Mertz, Gregory (2019)

  Small mammals present in areas where hantavirus cardiopulmonary syndrome (HCPS) cases had occurred in central and southern Chile were captured and analyzed to evaluate theabundance of rodents and seroprevalence rates of ...
• Statistical Analysis plan of the Head Position in acute ischemic Stroke Trial pilot 

  Olavarría, Verónica V.; Arima, Hisatomi; Anderson, Craig S.; Muñoz-Venturelli, Paula; Billot, Laurent; Lavados, Pablo M.; Brunser, Alejandro M. (2017)

  Background: The HEADPOST Pilot is a proof of concept, open, prospective, multicenter, international, cluster randomized, phase IIb controlled trial, with masked outcome assessment. The trial will test if lying flat ...
• Flat-head positioning increases cerebral blood flow in anterior circulation acute ischemic stroke. A cluster randomized phase IIb trial. 

  Lavados, Pablo M.; Muñoz-Venturelli, Paula; González, Francisca; Olavarría, Verónica V.; Gaete, Javier; Martins, Sheila; Arima, Hisatomi; Anderson, Craig S.; Brunser, Alejandro M. (2018)

  Background. Whether lying-flat improves blood flow in patients with acute ischemic stroke (AIS) is unknown. Our aim was to investigate if lying-flat ‘changes’ cerebral blood flow velocities (CBFV) assessed by transcranial ...
• Effects of 24-hours/day versus business hours physical therapy intervention in adult intensive care unit patients: a systematic review care unit patients 

  Merino, Catalina; Castro-Ávila, Ana Cristina; Gutiérrez-Arias, Ruvistay; Arriagada, María Jesús; Villanueva, Catalina; Leppe, Jaime; Fu, Carolina (2018)

  Background: Some evidence suggests that higher doses of mobilization could have benefits on functional status. However, the impact of increasing the availability of Physical Therapist in the intensive care unit to provide ...
• Chilean version of the Functional Status Score for the Intensive Care Unit: a translation and cross-cultural adaptation 

  González-Seguel, Felipe; Camus-Molina, Agustín; Leppe, Jaime; Hidalgo-Cabalín, Viviane; Gutiérrez-Panchana, Tania; Needham, Dale; Guimaraes, Fernando (2019)

  Background: The Functional Status Score for the Intensive Care Unit (FSS-ICU) is a valid and reliable instrument to measure physical functioning in the intensive care unit setting. Translation and cross-cultural adaptation ...
• International Classification of Functioning, Disability, and Health Domains of 60 Physical Functioning Measurement Instruments Used During the Adult Intensive Care Unit Stay: A Scoping Review. 

  González-Seguel, Felipe; Corner, Evelyn; Merino, Catalina (2019)

  BACKGROUND: There has been a recent surge in the creation and adaptation of instruments to measure physical functioning (PF) in the intensive care unit (ICU). Selecting the right measurement instrument depends on ...

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