• Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells 

  Duhan, Vikas; Khairnar, Vishal; Kitanovski, Simo; Hamdan, Thamer; Klein, Andrés; Lang, Judith; Ali, Murtaza; Adomati, Tom; Bhat, Hilal; Friedrich, Sarah-Kim; Li, Fanghui; Krebs, Philippe; Futerman, Anthony; Addo, Marylyn; Hardt, Cornelia; Hoffmann, Daniel; Lang, Philipp; Lang, Karl (Frontiers Media SA, 2021)

  Early and strong production of IFN-I by dendritic cells is important to control vesicular stomatitis virus (VSV), however mechanisms which explain this cell-type specific innate immune activation remain to be defined. Here, ...
• Immune-related IncRNA LINC00944 responds to variations in ADAR1 levels and it is associated with breast cancer prognosis 

  Blanco, Alejandro; Morales, Fernanda; Marcelain, Katherine; Harismendy, Olivier; Sjöberg, Marcela; Armisen, Ricardo; de Santiago, Pamela (Elsevier Inc., 2020)

  Aims: Breast cancer is one of the leading causes of woman deaths worldwide, being a major public health problem. It has been reported that the expression of the RNA-editing enzyme Adenosine Deaminase Acting on RNAs 1 (ADAR1) ...
• Colangiocarcinoma. Evaluación por Tomografía Computada y Resonancia Magnética 

  Sánchez, Lucía; Labra, Andrés; Schiappacasse, Giancarlo (Soc. Argentina de Radiología, 2019)

  El colangiocarcinoma (CC) es el segundo tumor primario maligno más frecuente del hígado. La mayor incidencia se registra en Asia y su pronóstico es poco alentador. La resección quirúrgica del tumor es el único tratamiento ...
• ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage response 

  Sagredo, Eduardo; Sagredo, Alfredo; Blanco, Alejandro; Rojas, Pamela; Rivas, Solange; Assar, Rodrigo; Pérez, Paola; Marcelain, Katherine; Armisen, Ricardo (Elsevier B.V., 2020)

  RNA editing has emerged as a novel mechanism in cancer progression. The double stranded RNA-specific adenosine deaminase (ADAR) modifies the expression of an important proportion of genes involved in cell cycle control, ...
• A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability 

  Pinto, Mauricio; Córdova-Delgado, Miguel; Retamal, Ignacio; Muñoz-Medel, Matías; Bravo, Loreto; Durán, Doris; Villanueva, Francisco; Sánchez, César; Acevedo, Francisco; Mondaca, Sebastián; Érica, Koch; Ibáñez, Carolina; Galindo, Héctor; Madrid, Jorge; Nervi, Bruno; Peña, José; Torres, Javiera; Garrido, Marcelo (MDPI, Basel Sz., 2020)

  Gastric cancer (GC) is a complex and heterogeneous disease. In recent decades, The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG) defined GC molecular subtypes. Unfortunately, these systems require ...
• Ski Is Required for Tri-Methylation of H3K9 in Major Satellite and for Repression of Pericentromeric Genes: Mmp3, Mmp10 and Mmp13, in Mouse Fibroblasts 

  Capelli, Claudio; Sepúlveda, Hugo; Rivas, Solange; Víctor, Paola; Urzúa, Ulises; Donoso, Gerardo; Sagredo, Eduardo; Carrero, David; Casanova-Ortiz, Emmanuel; Sagredo, Alfredo; González, Marisel; Manterola, Marcia; Nardocci, Gino; Armisen, Ricardo; Montecino, Martín; Marcelain, Katherine (Elsevier Ltd., 2020)

  Several mechanisms directing a rapid transcriptional reactivation of genes immediately after mitosis have been described. However, little is known about the maintenance of repressive signals during mitosis. In this work, ...
• Lack of Annexin A6 exacerbates liver dysfunction and reduces lifespan of NPC1- deficient mice 

  Meneses-Salas, Elsa; Garcia-Forn, Marta; Castany-Pladevall, Carla; Lu, Albert; Fajardo, Alba; José, Jaimy; Wahba, Mohamed; Bosch, Marta; Pol, Albert; Tebar, Francesc; Klein, Andrés; Zanlungo, Silvana; Pérez-Navarro, Esther; Grewal, Thomas; Enrich, Carlos; Rentero, Carles (Elsevier Inc./ American Society for Investigative Pathology, 2020)

  Niemann-Pick type C disease (NP-C) is a lysosomal storage disorder characterized by cholesterol accumulation caused by loss-of-function mutations in the Npc1 gene. NP-C disease primarily affects the brain, causing neuronal ...
• Transcriptomic characterization provides insights into Hantavirus Cardiopulmonary Syndrome (HCPS) severity 

  Esteves Ribeiro, Grazielle (Universidad del Desarrollo. Facultad de Medicina, 2020)

  Hantaviruses are important human pathogens that cause a severe zoonotic disease called hantavirus cardiopulmonary syndrome (HCPS), presenting a case fatality rate up to 40%. Clinical course of HCPS may present as a mild ...
• c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder 

  Contreras, Pablo; Tapia, Pablo; González-Hodar, Lila; Peluso, Ivana; Soldati, Chiara; Napoiotano, Gennaro; Matarese, María; Las Heras, Macarena; Valls, Cristian; Martínez, Alexis; Balboa, Elisa; Castro, Juan; Nancy, Leal; Platt, Frances; Sobota, Andrzej; Winter, Dominic; Klein, Andrés; Medina, Diego; Ballabio, Andrea; Alvarez, Alejandra; Zanlungo, Silvana (Cell Press, 2020)

  The transcription factor EB (TFEB) has emerged as a master regulator of lysosomal biogenesis, exocytosis, and autophagy, promoting the clearance of substrates stored in cells. c-Abl is a tyrosine kinase that participates ...
• Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study 

  Long, Georgina; Dummer, Reinhard; Hamid, Omid; Gajewski, Thomas; Caglevic, Christian; Dalle, Stephane; Arance, Ana; Carlino, Matteo; Grob, Jean-Jacques Grob; Kim, Tae; Demidov, Lev; Robert, Caroline; Larkin, James; Anderson, James; Maleski, Janet; Jones, Mark; Diede, Scott; Mitchell, Tara (Elsevier Ltd., 2019)

  Background: Immunotherapy combination treatments can improve patient outcomes. Epacadostat, an IDO1 selective inhibitor, and pembrolizumab, a PD-1 inhibitor, showed promising antitumour activity in the phase 1-2 ...
• Complete Sequence of the 22q11.2 Allele in 1,053 Subjects with 22q11.2 Deletion Syndrome Reveals Modifiers of Conotruncal Heart Defects 

  Zhao, Yingjie; Diacou, Alexander; Johnston, Richard; Musfee, Fadi; McDonald-McGinn, Donna; McGinn, Daniel; Crowley, Blaine; Repetto, Gabriela; Swillen, Ann; Breckpot, Jeroen; Vermeesch, Joris; Kates, Wendy; Digilio, Cristina; Unolt, Marta; Marino, Bruno; Pontillo, Maria; Armando, Marco; Di Fabio, Fabio; Vicari, Stefano; van den Bree, Marianne; Moss, Hayley; Owen, Michael; Murphy, Kieran; Murphy, Clodagh; Murphy, Declan; Schoch, Kelly; Shashi, Vandana; Tassone, Flora (American Society of Human Genetics by Elsevier Inc., 2020-01)

  The 22q11.2 deletion syndrome (22q11.2DS) results from non-allelic homologous recombination between low-copy repeats termed LCR22. About 60%-70% of individuals with the typical 3 megabase (Mb) deletion from LCR22A-D have ...
• Exosomes on the border of species and kingdom intercommunication 

  Schuh, Christina; Cuenca, Jimena; Alcayaga-Miranda, Francisca; Khoury, Maroun (2019-08)

  Over the last decades exosomes have become increasingly popular in the field of medicine. While until recently they were believed to be involved in the removal of obsolete particles from the cell, it is now known that ...
• Saccadic Direction Errors are Associated with Impulsive Compulsive Behaviours in Parkinson's Disease Patients 

  Barbosa, Pedro; Kaski, Diego; Castro, Patricia; Andrew, Andrew; Warner, Thomas; Djamshidian, Atbin (IOS Press, 2019)

  Fifteen individuals with Parkinson's disease (PD) and impulsive compulsive behaviours (PD+ICB) were compared to 15 PD patients without ICBs (PD-ICB) and 15 healthy controls (HC) on a pro-saccades and an anti-saccades task ...
• What Is the Significance of Variant Histology in Urothelial Carcinoma? 

  Lobo, Niyati; Shariat, Shahrokh; Guo, Charles; Fernández, Mario; Kassouf, Wassim; Choudhury, Ananya; Gao, Jianjun; Williams, Stephen; Galsky, Matthew; Taylor, John; Roupret, Morgan; Kamat, Ashish (European Association of Urology by Elsevier B.V, 2020-07)

  Context: Urothelial carcinoma can exhibit a wide range of variant morphologies. Many variants present diagnostic challenges and carry clinical implications that inform prognosis and treatment decisions. Objective: To ...
• Subjective stability perception is related to postural anxiety in older subjects 

  Castro, Patricia; Kaski, Diego; Schieppati, Marco; Furman, Michael; Arshad, Qadeer; Bronstein, Adolfo (Elsevier B.V., 2019-02)

  Background: Under static conditions, the objective and subjective measures of postural stability correlate well. However, age-related changes in postural control and task-related anxiety may modify the relationship between ...
• Sex differences in treatment and outcome after stroke: Pooled analysis including 19,000 participants 

  Carcel, Cheryl; Wang, Xia; Sandset, Else; Delcourt, Candice; Arima, Hisatomi; Lindley, Richard; Hackett, Maree; Lavados, Pablo; Robinson, Thompson; Muñoz-Venturelli, Paula; Olavarría, Verónica; Brunser, Alejandro; Berge, Eivind; Chalmers, John; Woodward, Mark; Anderson, Craig (American Academy of Neurology, 2019-12)

  Objective: To explore the sex differences in outcomes and management after stroke using a large sample with high-quality international trial data. Methods: Individual participant data were obtained from 5 acute stroke ...
• Targetable cellular signaling events mediate vascular pathology in vascular Ehlers-Danlos syndrome 

  Bowen, Caitlin; Calderón, Juan Francisco; Burger, Zachary; Rykiel, Graham; Davis, Elaine; Helmers, Mark; Benke, Kelly; Gallo, Elena; Dietz, Harry (American Society for Clinical Investigation., 2020-02)

  Vascular Ehlers-Danlos syndrome (vEDS) is an autosomal-dominant connective tissue disorder caused by heterozygous mutations in the COL3A1 gene, which encodes the pro-α 1 chain of collagen III. Loss of structural integrity ...
• Glucocorticoid Receptor-α and MKP-1 as Candidate Biomarkers for Treatment Response and Disease Activity in Vogt-Koyanagi-Harada Disease 

  Urzua, Cristhian; Chen, Ping; Chaigne-Delalande, Benjamin; Liu, Baoying; Anguita, Rodrigo; Guerrero, Julia; Sabat, Pablo; Velásquez, Víctor; Sen, Nida; Lee, Richard; Goecke, Annelise (Elsevier Inc, 2019-11)

  Purpose To investigate the potential of utilizing the expression of genes for glucocorticoid receptor (GR) and mitogen-activated protein kinase phosphatase-1 (MKP-1) as biomarkers of corticosteroid (CS) refractoriness and ...
• Laboratory exposure to Coccidioides: lessons learnt in a non-endemic country 

  Porte, Lorena; Valdivieso, Francisca; Wilmes, Dunja; Thompson, Luis; Munita, José; Varela, Carmen; Rickerts, Volker; Weitzel, Thomas; Gaete, P; Díaz, MC; Alliende, R (Elsevier Ltd, 2019-08)

  Coccidioides is a primary pathogenic fungus, which infects humans through highly infectious arthroconidia, causing substantial morbidity including life-threatening disseminated infections. Due to the low infectious dose, ...
• Shortage of yellow fever vaccination: A travel medicine emergency for Chilean travellers 

  Weitzel, Thomas; Vial, Pablo; Perret, Cecilia; Aguilera, Ximena (Elsevier Ltd., 2019-03)

  In recent years, yellow fever (YF) outbreaks have struck various African and South American countries, a scenario, which led to the creation of the “Eliminate Yellow fever Epidemics” initiative by the WHO [1]. The current ...

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