Complement Component C3 Participates in Early Stages of Niemann-Pick C Mouse Liver Damage

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Complement Component C3 Participates in Early Stages of Niemann–Pick C Mouse Liver Damage_Klein A et al.pdf (1.61 MB)

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2020

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Article

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Artículos Medicina y Ciencias de la Salud

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MDPI AG

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http://hdl.handle.net/11447/3276
 https://doi.org/10.3390/ijms21062127

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Abstract

Niemann-Pick type C (NPC), a lysosomal storage disorder, is mainly caused by mutations in the NPC1 gene. Niemann-Pick type C patients and mice show intracellular cholesterol accumulation leading to he...

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Centro de Genética y Genómica (ICIM)

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Citation

Klein, A.D.; González de la Vega, J.; Zanlungo, S. Complement Component C3 Participates in Early Stages of Niemann–Pick C Mouse Liver Damage. Int. J. Mol. Sci. 2020, 21, 2127.

Keywords

Niemann–Pick type C disease , Cholesterol , Complement cascade , Foam cells , Liver damage , Lysosomal storage diseases

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