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Association between history of psychosis and cardiovascular disease in bipolar disorder

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dc.contributor.author Prieto, Miguel
dc.contributor.author McElroy, Susan
dc.contributor.author Hayes, Sharonne
dc.contributor.author Sutor, Bruce
dc.contributor.author Kung, Simon
dc.contributor.author Bobo, William
dc.contributor.author Fuentes, Manuel
dc.contributor.author Cuellar-Barboza, Alfredo
dc.contributor.author Crow, Scott
dc.contributor.author Ösby, Urban
dc.contributor.author Chauhan, Mohit
dc.contributor.author Westman, Jeanette
dc.contributor.author Geske, Jennifer
dc.contributor.author Colby, Colin
dc.contributor.author Ryu, Euijung
dc.contributor.author Biernacka, Joanna
dc.contributor.author Frye, Mark
dc.date.accessioned 2016-05-23T16:53:34Z
dc.date.available 2016-05-23T16:53:34Z
dc.date.issued 2015
dc.identifier.citation Bipolar Disorders, August 2015, vol.17, n°5, p.518-527
dc.identifier.uri http://hdl.handle.net/11447/312
dc.identifier.uri http://dx.doi.org/10.1111/bdi.12302
dc.description.abstract OBJECTIVES: To determine whether clinical features of bipolar disorder, such as history of psychosis, and cardiovascular disease (CVD) risk factors contribute to a higher risk of CVD among patients with bipolar disorder. METHODS: This cross-sectional study included a sample of 988 patients with bipolar I or bipolar II disorder or schizoaffective bipolar type confirmed by the Structured Clinical Interview for DSM-IV-TR disorders (SCID). Medical comorbidity burden was quantified utilizing the Cumulative Illness Severity Rating Scale (CIRS). This 13-item organ-based scale includes cardiac disease severity quantification. Confirmed by medical record review, patients who scored 1 (current mild or past significant problem) or higher in the cardiac item were compared by logistic regression to patients who scored 0 (no impairment), adjusting for CVD risk factors that were selected using a backwards stepwise approach or were obtained from the literature. RESULTS: In a multivariate model, age [odds ratio (OR) = 3.03, 95% confidence interval (CI): 1.66-5.54, p < 0.0001], hypertension (OR = 2.43, 95% CI: 1.69-3.55, p < 0.0001), and history of psychosis (OR = 1.48, 95% CI: 1.03-2.13, p = 0.03) were associated with CVD. When CVD risk factors from the literature were added to the analysis, age (OR = 3.19, 95% CI: 1.67-6.10, p = 0.0005) and hypertension (OR = 2.46, 95% CI: 1.61-3.76, p < 0.01) remained significant, with psychosis being at the trend level (OR = 1.43, 95% CI: 0.96-2.13, p = 0.08). CONCLUSIONS: The phenotype of psychotic bipolar disorder may reflect higher illness severity with associated cardiac comorbidity. Further studies are encouraged to clarify the effect of the disease burden (i.e., depression), lifestyle, and treatment interventions (i.e., atypical antipsychotics) on this risk association.
dc.language.iso en_US
dc.publisher John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
dc.subject Bipolar disorder
dc.subject Cardiovascular diseases
dc.subject Hypertension
dc.subject Phenotype
dc.subject Risk
dc.title Association between history of psychosis and cardiovascular disease in bipolar disorder
dc.type Artículo


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