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A 19 Year Analysis of Small Mammals Associated with Human Hantavirus Cases in Chile

Show simple item record Torrez-Pérez, Fernando Palma, Eduardo Boric-Bargetto, Dusan Vial, Cecilia Ferrés, Marcela Vial, Pablo Martínez-Valdebenito, Constanza Pavletic, Carlos Parra, Alonso Marquet, Pablo Mertz, Gregory 2019-11-26T14:52:11Z 2019-11-26T14:52:11Z 2019
dc.identifier.uri doi:10.3390/v11090848
dc.description Programa Hantavirus, Instituto de Ciencias e Innovación en Medicina (ICIM), Facultad de Medicina, Clínica Alemana Universidad del Desarrollo
dc.description.abstract Small mammals present in areas where hantavirus cardiopulmonary syndrome (HCPS) cases had occurred in central and southern Chile were captured and analyzed to evaluate theabundance of rodents and seroprevalence rates of antibodies to Andes orthohantavirus (ANDV). Sampling areas ranged from the Coquimbo to Aysén regions (30–45° S approx.) regions. Ninetytwo sites in peridomestic and countryside areas were evaluated in 19 years of sampling. An antibody against ANDV was detected by strip immunoassay in 58 of 1847 specimens captured using Sherman traps. Of the eleven species of rodents sampled, Abrothrix olivacea, Oligoryzomys longicaudatus and Abrothrix hirta were the most frequently trapped. O. longicaudatus had the highest seropositivity rate, and by logistic regression analysis, O. longicaudatus of at least 60 g had 80% or higher probability to be seropositive. Sex, age and wounds were significantly related to seropositivity only for O. longicaudatus. Across administrative regions, the highest seropositivity was found in the El Maule region (34.8–36.2° S), and the highest number of HCPS cases was registered in the Aysén region. Our results highlight the importance of long term and geographically extended studies, particularly for highly fluctuating pathogens and their reservoirs, to understand the implications of the dynamics and transmission of zoonotic diseases in human populations.
dc.language.iso en
dc.subject Hantavirus
dc.subject Síndrome cardiopulmonar
dc.subject Andes orthohantavirus
dc.subject Oligoryzomys longicaudatus
dc.title A 19 Year Analysis of Small Mammals Associated with Human Hantavirus Cases in Chile
dc.type Article

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