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Clinical characterization of rapid cycling bipolar disorder: Association with attention deficit hyperactivity disorder

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dc.contributor.author Aedoa, Alberto
dc.contributor.author Murrub, Andrea
dc.contributor.author Sanchez, Raúl
dc.contributor.author Grandeb, Iria
dc.contributor.author Vieta, Eduard
dc.contributor.author Undurraga, Juan
dc.date.accessioned 2019-07-09T14:41:11Z
dc.date.available 2019-07-09T14:41:11Z
dc.date.issued 2018
dc.identifier.citation J Affect Disord. 2018;240:187-192. doi: 10.1016/j.jad.2018.07.051. es
dc.identifier.uri doi: 10.1016/j.jad.2018.07.051. es
dc.identifier.uri http://hdl.handle.net/11447/2514
dc.description.abstract Backgraund: Rapid cycling (RC) bipolar disorder (BD) is associated with more disability and worse global functioning than non-rapid cycling BD (NRC) and is understudied. This study aims to investigate clinical characteristics associated to RC in a Latin-American sample and secondarily, to generate a clinical model to test the likelihood of RC in BD. Methods: 250 BD patients were enrolled between 2007 and 2015. All patients met DSM-IV criteria for BD type I, II or NOS. The sample was dichotomized into RC and NRC subgroups, and compared in terms of sociodemographic and clinical variables by bivariate analyses. A binary logistic regression was performed to generate a model and explain variance associated with the likelihood of presenting RC. Results: Final sample included 235 patients, of which forty-four (18.7%) met RC criteria. When compared to NRC, a significantly higher proportion of RC patients were female (81.4% vs. 58.9% p = 0.006), BD type II (58.1% vs. 29.7% p = 0.002), presented more manic/hypomanic episodes (43.6 ± 35.8 vs. 12.8 ± 58.9, p = 0.001), and had less psychotic symptoms (20.9% vs. 42.2%, p = 0.010). Attention deficit hyperactivity disorder (ADHD) was a significant comorbidity in RC (23.7% vs. 8.3%, p = 0.007). No differences were found in suicidality, mixed symptoms, and seasonal pattern. After logistic regression, variables significantly associated with RC were presence of ADHD (OR 4.6 [95% CI 1.54-13.93] p = 0.006) and female gender (OR 3.55 [95% CI, 1.32-9.56] p = 0.012). Limitations: It is a cross-sectional study. Conclusions: Findings suggest that ADHD comorbidity, and female gender are risk factors for RC in BD. es
dc.language.iso en es
dc.publisher Elsevier B.V. es
dc.subject ADHD es
dc.subject Bipolar disorder es
dc.subject Female gender es
dc.subject Rapid-cycling es
dc.title Clinical characterization of rapid cycling bipolar disorder: Association with attention deficit hyperactivity disorder es
dc.type Article es


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