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Clinical characterization of rapid cycling bipolar disorder: Association with attention deficit hyperactivity disorder

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dc.contributor.author Aedoa, Alberto
dc.contributor.author Murrub, Andrea
dc.contributor.author Sanchez, Raúl
dc.contributor.author Grandeb, Iria
dc.contributor.author Vieta, Eduard
dc.contributor.author Undurraga, Juan
dc.date.accessioned 2019-07-09T14:41:11Z
dc.date.available 2019-07-09T14:41:11Z
dc.date.issued 2018
dc.identifier.citation J Affect Disord. 2018;240:187-192. doi: 10.1016/j.jad.2018.07.051.
dc.identifier.uri http://hdl.handle.net/11447/2514
dc.identifier.uri doi: 10.1016/j.jad.2018.07.051.
dc.description.abstract Backgraund: Rapid cycling (RC) bipolar disorder (BD) is associated with more disability and worse global functioning than non-rapid cycling BD (NRC) and is understudied. This study aims to investigate clinical characteristics associated to RC in a Latin-American sample and secondarily, to generate a clinical model to test the likelihood of RC in BD. Methods: 250 BD patients were enrolled between 2007 and 2015. All patients met DSM-IV criteria for BD type I, II or NOS. The sample was dichotomized into RC and NRC subgroups, and compared in terms of sociodemographic and clinical variables by bivariate analyses. A binary logistic regression was performed to generate a model and explain variance associated with the likelihood of presenting RC. Results: Final sample included 235 patients, of which forty-four (18.7%) met RC criteria. When compared to NRC, a significantly higher proportion of RC patients were female (81.4% vs. 58.9% p = 0.006), BD type II (58.1% vs. 29.7% p = 0.002), presented more manic/hypomanic episodes (43.6 ± 35.8 vs. 12.8 ± 58.9, p = 0.001), and had less psychotic symptoms (20.9% vs. 42.2%, p = 0.010). Attention deficit hyperactivity disorder (ADHD) was a significant comorbidity in RC (23.7% vs. 8.3%, p = 0.007). No differences were found in suicidality, mixed symptoms, and seasonal pattern. After logistic regression, variables significantly associated with RC were presence of ADHD (OR 4.6 [95% CI 1.54-13.93] p = 0.006) and female gender (OR 3.55 [95% CI, 1.32-9.56] p = 0.012). Limitations: It is a cross-sectional study. Conclusions: Findings suggest that ADHD comorbidity, and female gender are risk factors for RC in BD.
dc.language.iso en
dc.publisher Elsevier B.V.
dc.subject ADHD
dc.subject Bipolar disorder
dc.subject Female gender
dc.subject Rapid-cycling
dc.title Clinical characterization of rapid cycling bipolar disorder: Association with attention deficit hyperactivity disorder
dc.type Article


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