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Anxiety can significantly explain bolus perception in the context of hypotensive esophageal motility: Results of a large multicenter study in asymptomatic individuals

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dc.contributor.author Cisternas, Daniel
dc.contributor.author Scheerens, Charlotte
dc.contributor.author Omari, Taher
dc.contributor.author Monrroy, Hugo
dc.contributor.author Hani, Albis
dc.contributor.author Leguizamo, A
dc.contributor.author Bilder, C
dc.contributor.author Ditaranto, A
dc.contributor.author Ruiz de León, A
dc.contributor.author Pérez de la Serna, J
dc.contributor.author Valdovinos, Miguel
dc.contributor.author Coello, R
dc.contributor.author Abrahao, L
dc.contributor.author Remes-Troche, Jose
dc.contributor.author Meixueiro, A
dc.contributor.author Zavala, M
dc.contributor.author Marin, I
dc.contributor.author Serra, J
dc.date.accessioned 2018-01-18T14:11:23Z
dc.date.available 2018-01-18T14:11:23Z
dc.date.issued 2017
dc.identifier.citation Neurogastroenterol Motil. 2017 Sep;29(9)
dc.identifier.uri http://hdl.handle.net/11447/1916
dc.identifier.uri http://dx.doi.org/10.1111/nmo.13088
dc.description.abstract BACKGROUND: Previous studies have not been able to correlate manometry findings with bolus perception. The aim of this study was to evaluate correlation of different variables, including traditional manometric variables (at diagnostic and extreme thresholds), esophageal shortening, bolus transit, automated impedance manometry (AIM) metrics and mood with bolus passage perception in a large cohort of asymptomatic individuals. METHODS: High resolution manometry (HRM) was performed in healthy individuals from nine centers. Perception was evaluated using a 5-point Likert scale. Anxiety was evaluated using Hospitalized Anxiety and Depression scale (HAD). Subgroup analysis was also performed classifying studies into normal, hypotensive, vigorous, and obstructive patterns. KEY RESULTS: One hundred fifteen studies were analyzed (69 using HRM and 46 using high resolution impedance manometry (HRIM); 3.5% swallows in 9.6% of volunteers were perceived. There was no correlation of any of the traditional HRM variables, esophageal shortening, AIM metrics nor bolus transit with perception scores. There was no HRM variable showing difference in perception when comparing normal vs extreme values (percentile 1 or 99). Anxiety but not depression was correlated with perception. Among hypotensive pattern, anxiety was a strong predictor of variance in perception (R2 up to .70). CONCLUSION AND INFERENCES: Bolus perception is less common than abnormal motility among healthy individuals. Neither esophageal motor function nor bolus dynamics evaluated with several techniques seems to explain differences in bolus perception. Different mechanisms seem to be relevant in different manometric patterns. Anxiety is a significant predictor of bolus perception in the context of hypotensive motility.
dc.format.extent 10
dc.language.iso en_US
dc.publisher John Wiley & Sons
dc.subject anxiety
dc.subject automated impedance manometry
dc.subject bolus perception
dc.subject high resolution esophageal manometry
dc.subject hypotensive motility
dc.title Anxiety can significantly explain bolus perception in the context of hypotensive esophageal motility: Results of a large multicenter study in asymptomatic individuals
dc.type Artículo


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