Intracerebral stem cell administration inhibits relapse-like alcohol drinking in rats
Date
2017
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Artículo
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4
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Publisher
Oxford University Press
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Abstract
Study describes the blockade of relapse-like alcohol drinking by mesenchymal stem cells (MSCs). High alcohol-intake bred rats consumed alcohol for 3 months and were subjected to repeated alcohol deprivations for 7-14 days, followed by alcohol reaccess. Upon reaccess, animals consumed 2.2 g alcohol/kg in 60 minutes. A single intra-cerebroventricular MSC administration inhibited relapse-like drinking up to 80-85% for 40 days (P < 0.001). An alcohol-use-disorder was prevented.
Description
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Citation
Israel Y, Ezquer F, Quintanilla ME, Morales P, Ezquer M, Herrera-Marschitz M. Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats. Alcohol Alcohol. 2017 Jan;52(1):1-4.
Keywords
Ethanol, Stem cells, Alcohol drinking, Rats