Institutional Repository UDD

Absence of convincing evidence of Coxiella burnetii infection in Chile: a cross-sectional serosurvey among healthy adults in four different regions

Show simple item record

dc.contributor.author Weitzel, Thomas
dc.contributor.author Lopez, Javier
dc.contributor.author Acosta-Jamett, Gerardo
dc.contributor.author Edouard, Sophie
dc.contributor.author Parola, Philippe
dc.contributor.author Abarca, Katia
dc.date.accessioned 2017-08-16T12:16:40Z
dc.date.available 2017-08-16T12:16:40Z
dc.date.issued 2016
dc.identifier.citation BMC Infectious Diseases (2016) 16:541
dc.identifier.uri http://hdl.handle.net/11447/1573
dc.identifier.uri http://dx.doi.org/10.1186/s12879-016-1880-9
dc.description.abstract Background: Coxiella burnetii is an important zoonotic pathogen of global distribution. Still, in most parts of South America including Chile, systematic epidemiological data are lacking. The presented study aims to determine the seroprevalence of Coxiella burnetii antibodies in healthy adults of four different regions in Chile. Methods: A cross-sectional study was performed, which included healthy adults living in rural and urban areas of four cities located in different regions in northern, central, and southern Chile. In urban sectors, households were chosen by double stratified random sampling, while in rural areas convenience sampling was performed. Serum specimens were taken and screened for the presence of IgG antibodies against C. burnetii phase II antigen using a commercial ELISA kit. Positive and indeterminate results were confirmed by a reference laboratory using indirect immunofluorescence assay (IFA). Results: A total of 1112 individuals were included. Of those, 8 were positive by ELISA, but only one sample was confirmed using IFA. Statistical analysis for population freedom from disease revealed a high probability that C. burnetii was absent in our study population. Conclusion: Our work provides the first epidemiological data on human Q fever in Chile indicating either a very low endemicity or the absence of this pathogen in the studied areas.
dc.format.extent 6
dc.language.iso en_US
dc.publisher BMJ Publishing Group
dc.subject Q fever
dc.subject Coxiella burnetii
dc.subject Epidemiology
dc.subject Seroprevalence
dc.subject Zoonoses
dc.subject South America
dc.title Absence of convincing evidence of Coxiella burnetii infection in Chile: a cross-sectional serosurvey among healthy adults in four different regions
dc.type Artículo


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Browse

My Account