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Diferencia veno-arterial de dióxido de carbono como predictor de gasto cardiaco disminuido en modelo pediátrico experimental

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dc.contributor.author Díaz, Franco
dc.contributor.author Donoso, Alejandro
dc.contributor.author Carvajal, Cristóbal
dc.contributor.author Salomón, Tatiana
dc.contributor.author Torres, María
dc.contributor.author Erranz, Benjamín
dc.contributor.author Cruces, Pablo
dc.date.accessioned 2017-05-24T16:02:09Z
dc.date.available 2017-05-24T16:02:09Z
dc.date.issued 2012
dc.identifier.citation Rev Med Chil. 2012 Jan;140(1):39-44 es_CL
dc.identifier.uri http://dx.doi.org/10.4067/S0034-98872012000100005 es_CL
dc.identifier.uri http://hdl.handle.net/11447/1311
dc.description Centro de Medicina Regenerativa es_CL
dc.description.abstract Background: Cardiac output (CO) measurement is not a standard of care for critically ill children, but it can be estimated by indirect methods such as veno-arterial pCO2 difference (ΔVACO2). Aim: To determine the correlation between CO and ΔVACO2 and evaluate the usefulness of ΔVACO2 in the diagnosis of low CO in an experimental pediatric model. Materials and Methods: Thirty piglets weighing 4.8 ± 0.35 kg were anesthetized and monitored with transpulmonary thermodilution. Lung injury was induced with tracheal instillation of Tween 20®. Serial measurements of central venous and arterial blood gases, as well as CO, were obtained at baseline, 1, 2 and 4 h after lung injury induction. Low cardiac output (LCO) was defined as CO lower than 2.5 Llminlm2. Results: There was an inverse correlation between CO and ΔVACO2 (r = -0.36, p < 0.01). ΔVACO2 was 14 ± 8 mmHg in LCO state and 8 ± 6 mmHg when this condition was not present (p < 0.01). Area under the receiver operating characteristic (ROC) curves of ΔVACO2 and LCO state was 0.78 (0.68-0.86). The best cut-point was 8.9 mmHg to determine LCO with a sensibility 0.78, specificity 0.7, positive predictive value 0.27 and negative predictive value 0.96. Conclusions: In this model there was an inverse correlation between ΔVACO2 and CO. The best cutoff value to discard LCO was ΔVACO2 of 8.9 mmHg, indicating that under this value the presence of LCO is very unlikely. es_CL
dc.format.extent 6 es_CL
dc.language.iso spa es_CL
dc.publisher Sociedad Medica de Santiago es_CL
dc.subject Blood gas monitoring es_CL
dc.subject Carbon Dioxide es_CL
dc.subject Critical Care es_CL
dc.subject Hemodynamics es_CL
dc.subject Cardiac Output es_CL
dc.title Diferencia veno-arterial de dióxido de carbono como predictor de gasto cardiaco disminuido en modelo pediátrico experimental es_CL
dc.title.alternative Veno-arterial difference of carbondioxide as a predictor of low cardiac output in an experimental pediatric model es_CL
dc.type Artículo es_CL


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