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The mini-PET in pediatric peritoneal dialysis: a useful tool to predict volume overload?

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dc.contributor.author Cano, Francisco
dc.contributor.author Rojo, Angélica
dc.contributor.author Azocar, Marta
dc.contributor.author Ibacache, María
dc.contributor.author Delucchi, Ángela
dc.contributor.author Ugarte, Francisca
dc.contributor.author Irarrazabal, Carlos
dc.contributor.author Delgado, Iris
dc.date.accessioned 2017-04-06T15:25:23Z
dc.date.available 2017-04-06T15:25:23Z
dc.date.issued 2013
dc.identifier.citation Pediatr Nephrol. 2013 Jul;28(7):1121-1126 es_CL
dc.identifier.uri http://dx.doi.org/10.1007/s00467-013-2447-2 es_CL
dc.identifier.uri http://hdl.handle.net/11447/1099
dc.description Centro de Epidemiología y Políticas de Salud es_CL
dc.description.abstract BACKGROUND: Cardiovascular disease (CVD) in patients on chronic peritoneal dialysis (PD) is a major cause of death and is closely linked to hypertension and volume overload. The mini-Pet has been proposed as a useful tool to evaluate free-water transport (FWT) and characterize ultrafiltration across the peritoneum. Knowledge regarding FWT could be of great value to predict volume overload in PD patients. Our objective in this study was to characterize FWT through the peritoneum in children on PD. METHODS: We studied clinically stable patients with >2 months on PD. Exclusion criteria were a peritonitis episode up to 2 months prior to entrance into the study and active nephrotic syndrome. A 1-h mini-peritoneal equilibration test (mini-PET) was performed with 3.86 % glucose. Calculations (see text for full definitions) were: Dip Na (Na dial min60 - Na dial min1), Dip D/PNa (D/PNa60 - D/PNa1), total Na removal (NaR = total Na dial60 - Na dial1), ultrafiltration small pores [(UFSP = NaR × 1,000)/Nap], and FWT (UF-UFSP). Peritoneal equilibration test (PET), left ventricular mass index (LVMI, g/m(2)), daily UF, and residual renal function were evaluated. Pearson's correlation coefficient was used to establish correlation between variables. RESULTS: Sixteen patients were included, with a mean age of 11.8 ± 3.8 years. Free water transport normalized to body surface area (BSA) (FWTn) was 133.9 ± 85.7 ml/m(2); creatinine dialysate-to-plasma (D/P) and glucose dialysate at X dwell time-to-0 dwell time (Dx/D0) ratios were 0.38 ± 0.1 and 0.65 ± 0.09, respectively. LVMI was 46.6 ± 14.8 g/m(2); 2-h creatinine D/P and glucose Dx/D0 showed no correlation with FWTn, UF, and LVMI. FWTn showed a significant inverse correlation with LVMI (r 0.58, p 0.02). CONCLUSIONS: This study characterized FWT in PD children through the mini-PET. Left ventricular hypertrophy showed a high prevalence in this group, and a significant correlation between LVMI and FWT was found. FWT could be a useful tool to evaluate UF in PD children. es_CL
dc.format.extent 6 es_CL
dc.language.iso en_US es_CL
dc.publisher Springer es_CL
dc.subject Mini-PET es_CL
dc.subject Adequacy es_CL
dc.subject Peritoneal transport es_CL
dc.subject Peritoneal dialysis es_CL
dc.subject Free water transport es_CL
dc.subject Peritoneal equilibrium test es_CL
dc.title The mini-PET in pediatric peritoneal dialysis: a useful tool to predict volume overload? es_CL
dc.type Artículo es_CL


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