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Case-fatality of acute ischemic stroke in stroke units of Latin American hospitals

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dc.contributor.authorVences, Miguel
dc.contributor.authorBarboza, Miguel
dc.contributor.authorCarbonera, Leonardo
dc.contributor.authorFailoc, Virgilio
dc.contributor.authorRosales, Julieta
dc.contributor.authorAmaya, Pablo
dc.contributor.authorLavados, Pablo
dc.contributor.authorFAICAM Registry Group
dc.date.accessioned2026-08-19T15:27:17Z
dc.date.available2026-08-19T15:27:17Z
dc.date.issued2025
dc.description.abstractBackground and purpose: The Case-fatality of acute ischemic stroke in stroke units of Latin American hospitals is a multicenter registry from various stroke centers in Latin America, exploring demographic, clinical, imaging, and functional outcomes in acute ischemic stroke (AIS) patients, with the intention of determining case-fatality rates (in-hospital, 30 and 90 days follow up) and analyzing associated risk factors. Methods: We conducted a retrospective cohort study using data from hospitalized AIS patients over 18 years of age, collected from 27 centers in 11 Latin American countries between January 1 and December 31, 2022. The effect size was estimated using the hazard ratio (HR) and 95 % confidence intervals (95 % CI) through Cox regression models to assess the association between time to 30-day fatality event and covariates. Results: A total of 2,997 patients were included. The mean age was 68.7 years and 48.1 % were women. In-hospital case-fatality was 9.42 %, 277 patients (10.2 %) died within 30 days, and 90-day case-fatality was relatively close at 353 patients (13.3 %). Complications were reported in 31.3 % of cases, most frequently infections (18.5 %). Age over 75 years (HRa=2.28), hyperglycemia (HRa=1.28), baseline status (HRa=1.61), stroke severity according to NIHSS >26 (HRa=6.11) and the presence of neurological complications (HRa=3.2) were risk factors for 30-day follow up case-fatality in these patients. Conclusion: AIS patients in Latin America stroke centers had an in-hospital case-fatality of 9.42 % and the 30-day case-fatality was 10.2 %. Older age, hyperglycemia, baseline status, stroke severity and neurological complications were the strongest predictors of early case-fatality. The findings underscore the need to optimize stroke management protocols in the region.
dc.description.versionVersión Publicada
dc.identifier.citationVences MA, Barboza MA, Carbonera LA, Failoc-Rojas VE, Rosales J, Amaya P, Lavados P; FAICAM Registry Group. Case-fatality of acute ischemic stroke in stroke units of Latin American hospitals. J Stroke Cerebrovasc Dis. 2025 Sep;34(9):108396. doi: 10.1016/j.jstrokecerebrovasdis.2025.108396. Epub 2025 Jul 9. PMID: 40645356.
dc.identifier.doihttps://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108396
dc.identifier.urihttps://hdl.handle.net/11447/11021
dc.language.isoen
dc.titleCase-fatality of acute ischemic stroke in stroke units of Latin American hospitals
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceJournal of Stroke and Cerebrovascular Diseases
dspace.entity.typePublication
relation.isAuthorOfPublicationce883977-0c50-41ce-a8ce-8adb22c2d09b
relation.isAuthorOfPublication.latestForDiscoveryce883977-0c50-41ce-a8ce-8adb22c2d09b

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