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The Impact of an Interactive Guidance Intervention on Sustained Social Withdrawal in Preterm Infants in Chile: Randomized Controlled Trial

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dc.contributor.authorBustamante, Jorge
dc.contributor.authorPérez, Marcela
dc.contributor.authorMendiburo, Andrés
dc.contributor.authorClaude, Antoine
dc.contributor.authorSalinas, Ricardo
dc.contributor.authorMuñoz , Lucia
dc.contributor.authorCox, Horacio
dc.contributor.authorGonzález, José
dc.contributor.authorSimó, Sandra
dc.contributor.authorMorgues, Mónica
dc.date.accessioned2023-07-10T17:04:28Z
dc.date.available2023-07-10T17:04:28Z
dc.date.issued2022
dc.description.abstractBackground: Sustained social withdrawal is a key indicator of child emotional distress and a risk factor for psychological development. Preterm infants have a higher probability of developing sustained social withdrawal than infants born full-term during their first year. Objective: To compare the effect of a behavioral guidance intervention to that of routine pediatric care on sustained social withdrawal behavior in preterm infants. Design: Multicenter randomized clinical trial. Participants: Ninety nine moderate and late preterm newborns and their parents were recruited and randomized into two groups, i.e., Intervention (n = 49) and Control (n = 50). Both groups attended medical check-ups at 2, 6 and 12 months and were assessed with the Alarm Distress Baby Scale. The intervention group received a standardized behavioral intervention if the neonatologist detected sustained social withdrawal. Also, parents filled out the Edinburgh Postnatal Depression Scale, the modified-Perinatal Posttraumatic Stress Disorder Questionnaire, and the Impact of Event Scale-revised. Results: At baseline, the prevalence of withdrawal was 4.0% (95% CI: 0.03-14.2) for the control group and 22.4% (95% CI: 13.0-35.9) for the intervention group [OR = 0.22, p = 0.028 (95% CI =0.06-0.84)]. At 6 months, the prevalence was 10.0% (95% CI: 3.9-21.8) for the control group and 6.1% (95% CI: 2.1-16.5) for the intervention group [OR = 2.09, p = 0.318 (95% CI = 0.49-8.88)]. At 12 months, the prevalence was 22.0% (95% CI: 12.8-35.2) for the control group and 4.1% (95% CI: 1.1-13.7) for the intervention group [OR = 6.63, p = 0.018 (95% CI = 1.39-31.71)]. Logistic generalized estimating equation models were performed. The pooled crude OR (considering diagnosis at 6 and 12 months) was 3.54 [p = 0.022 (95% CI = 1.20-10.44); Cohen's d= 0.70]. In the case of pooled adjusted OR, the model considered diagnosis (0 = Withdrawal, 1 = Normal) as the dependent variable, time of evaluation (1= 6 months, 2 = 12 months) and group (0 = Control, 1 = Experimental) as factors. In this case, the pooled adjusted OR was 3.57 [p = 0.022 (95% CI = 1.20-10.65); Cohen's d = 0.70]. Conclusion: Assessment and intervention of sustained social withdrawal in preterm infants via standardized instruments benefits families by reducing its prevalence, and possible associated negative outcomes. Clinical trial registration: ClinicalTrials.gov; https://clinicaltrials.gov/ct2/show/NCT03212547, identifier: NCT03212547.
dc.description.versionVersión Publicada
dc.identifier.citationBustamante Loyola J, Pérez Retamal M, Mendiburo-Seguel A, Guedeney AC, Salinas González R, Muñoz L, Cox Melane H, González Mas JM, Simó Teufel S, Morgues Nudman M. The Impact of an Interactive Guidance Intervention on Sustained Social Withdrawal in Preterm Infants in Chile: Randomized Controlled Trial. Front Pediatr. 2022 Apr 1;10:803932. doi: 10.3389/fped.2022.803932
dc.identifier.doihttps://doi.org/10.3389/fped.2022.803932
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7677
dc.language.isoen
dc.subjectEarly detection
dc.subjectEmotional distress
dc.subjectInteractive guidance
dc.subjectPostnatal depression
dc.subjectPosttraumatic stress (PTS)
dc.subjectPreterm (birth)
dc.subjectSocial development
dc.subjectSocial withdrawal
dc.titleThe Impact of an Interactive Guidance Intervention on Sustained Social Withdrawal in Preterm Infants in Chile: Randomized Controlled Trial
dc.typeArticle
dcterms.abstractAcceso Abierto
dcterms.sourceFrontiers in pediatrics
dspace.entity.typePublication

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