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Folate and Vitamin B12 Levels in Chilean Women with PCOS and Their Association with Metabolic Outcomes

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dc.contributor.authorCarrasco, Matías
dc.contributor.authorSilveira, Taís
dc.contributor.authorMartínez, Paz
dc.contributor.authorCerpa, Leslie
dc.contributor.authorCalfunao, Susan
dc.contributor.authorEchiburú, Bárbara
dc.contributor.authorMaliqueo, Manuel
dc.contributor.authorCrisosto, Nicolás
dc.contributor.authorSalas, Francisca
dc.date.accessioned2025-01-28T14:44:03Z
dc.date.available2025-01-28T14:44:03Z
dc.date.issued2024
dc.description.abstractPolycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age. Many women with PCOS have been found to have an unbalanced diet and deficiencies in essential nutrients. This study aimed to assess the levels of folate and vitamin B12 (B12) and their relationship with metabolic factors in women with PCOS. Anthropometric, clinical, and genetic analyses were conducted to evaluate markers related to one-carbon metabolism in women with PCOS and in a control group. The PCOS group had a higher BMI and HOMA-IR (1.7 vs. 3.1; p < 0.0001). HDL cholesterol levels were 23% lower and triglyceride levels were 74% higher in women with PCOS. Although there were no significant differences in folate and B12 levels between the PCOS and control groups, over 60% of women with PCOS had low B12 levels (<300 pg/mL) and high homocysteine levels. In addition, the MTHFR A1298C and C677T polymorphisms were not associated with PCOS. Moreover, erythrocyte folate levels were positively correlated with fasting glucose, triglycerides, and free androgen index, and negatively correlated with SHBG and LH levels. These results suggest that B vitamins may be associated with the metabolic phenotype in PCOS. This study emphasizes the potential link between folate, vitamin B12, and metabolic and hormonal outcomes in women with PCOS.
dc.description.versionVersión Publicada
dc.identifier.citationCarrasco-Cabezas M, Assmann TS, Martínez P, Cerpa L, Calfunao S, Echiburú B, Maliqueo M, Crisosto N, Salas-Pérez F. Folate and Vitamin B12 Levels in Chilean Women with PCOS and Their Association with Metabolic Outcomes. Nutrients. 2024 Jun 19;16(12):1937. doi: 10.3390/nu16121937
dc.identifier.doihttps://doi.org/10.3390/nu16121937
dc.identifier.urihttps://hdl.handle.net/11447/9717
dc.language.isoen
dc.subjectMTHFR
dc.subjectPCOS
dc.subjectMetabolism
dc.subjectPolymorphism
dc.subjectVitamins
dc.titleFolate and Vitamin B12 Levels in Chilean Women with PCOS and Their Association with Metabolic Outcomes
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceNutrients
dspace.entity.typePublication

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