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High Burden of Intestinal Colonization With Antimicrobial-Resistant Bacteria in Chile: An Antibiotic Resistance in Communities and Hospitals (ARCH) Study

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dc.contributor.authorAraos Bralic, Rafael Ignacio
dc.contributor.authorSmith, Rachel
dc.contributor.authorStyczynski, Ashley
dc.contributor.authorSánchez, Felipe
dc.contributor.authorAcevedo, Johanna
dc.contributor.authorMaureira, Lea
dc.contributor.authorParedes, Catalina
dc.contributor.authorGonzález, Maite
dc.contributor.authorRivas Jiménez, Lina María
dc.contributor.authorSpencer, Maria
dc.contributor.authorPeters, Anne Sophie
dc.contributor.authorKhan, Ayesha
dc.contributor.authorSepulveda, Dino
dc.contributor.authorRojas, Loreto
dc.contributor.authorRioseco, María
dc.contributor.authorUsedo, Pedro
dc.contributor.authorRojas, Pamela
dc.contributor.authorHuidobro, Laura
dc.contributor.authorFerreccio, Catterina
dc.contributor.authorPark, Benjamin
dc.contributor.authorUndurraga, Eduardo
dc.contributor.authorD'Agata, Erika
dc.contributor.authorJara, Alejandro
dc.contributor.authorMunita, Jose M.
dc.date.accessioned2024-04-01T19:07:26Z
dc.date.available2024-04-01T19:07:26Z
dc.date.issued2023
dc.description.abstractBackground: Antimicrobial resistance is a global threat, heavily impacting low- and middle-income countries. This study estimated antimicrobial-resistant gram-negative bacteria (GNB) fecal colonization prevalence in hospitalized and community-dwelling adults in Chile before the coronavirus disease 2019 pandemic. Methods: From December 2018 to May 2019, we enrolled hospitalized adults in 4 public hospitals and community dwellers from central Chile, who provided fecal specimens and epidemiological information. Samples were plated onto MacConkey agar with ciprofloxacin or ceftazidime added. All recovered morphotypes were identified and characterized according to the following phenotypes: fluoroquinolone-resistant (FQR), extended-spectrum cephalosporin-resistant (ESCR), carbapenem-resistant (CR), or multidrug-resistant (MDR; as per Centers for Disease Control and Prevention criteria) GNB. Categories were not mutually exclusive. Results: A total of 775 hospitalized adults and 357 community dwellers were enrolled. Among hospitalized subjects, the prevalence of colonization with FQR, ESCR, CR, or MDR-GNB was 46.4% (95% confidence interval [CI], 42.9-50.0), 41.2% (95% CI, 37.7-44.6), 14.5% (95% CI, 12.0-16.9), and 26.3% (95% CI, 23.2-29.4). In the community, the prevalence of FQR, ESCR, CR, and MDR-GNB colonization was 39.5% (95% CI, 34.4-44.6), 28.9% (95% CI, 24.2-33.6), 5.6% (95% CI, 3.2-8.0), and 4.8% (95% CI, 2.6-7.0), respectively. Conclusions: A high burden of antimicrobial-resistant GNB colonization was observed in this sample of hospitalized and community-dwelling adults, suggesting that the community is a relevant source of antibiotic resistance. Efforts are needed to understand the relatedness between resistant strains circulating in the community and hospitals.
dc.description.versionPublicada
dc.identifier.citationAraos R, Smith RM, Styczynski A, Sánchez F, Acevedo J, Maureira L, Paredes C, González M, Rivas L, Spencer-Sandino M, Peters A, Khan A, Sepulveda D, Wettig LR, Rioseco ML, Usedo P, Soto PR, Huidobro LA, Ferreccio C, Park BJ, Undurraga E, D'Agata EMC, Jara A, Munita JM. High Burden of Intestinal Colonization With Antimicrobial-Resistant Bacteria in Chile: An Antibiotic Resistance in Communities and Hospitals (ARCH) Study. Clin Infect Dis. 2023 Jul 5;77(Suppl 1):S75-S81. doi: 10.1093/cid/ciad283.
dc.identifier.doihttps://doi.org/10.1093/cid/ciad283
dc.identifier.urihttps://hdl.handle.net/11447/8573
dc.language.isoen
dc.subjectLatin America
dc.subjectAntimicrobial-resistance
dc.subjectColonization
dc.subjectCommunity
dc.subjectGram-negative
dc.titleHigh Burden of Intestinal Colonization With Antimicrobial-Resistant Bacteria in Chile: An Antibiotic Resistance in Communities and Hospitals (ARCH) Study
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceClinical infectious diseases : an official publication of the Infectious Diseases Society of America
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery69e40056-7a55-41b3-8a65-05aace0e07e3

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