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Colonization with antibiotic resistant bacteria in communities and hospitals across six countries, including Bangladesh, Botswana, Chile, Guatemala, India, and Kenya

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dc.contributor.authorParra, Gemma
dc.contributor.authorLautenbach, Ebbing
dc.contributor.authorMosepele, Mosepele
dc.contributor.authorMannathoko, Naledi
dc.contributor.authorGross, Robert
dc.contributor.authorCall, Douglas
dc.contributor.authorRamay, Brooke
dc.contributor.authorOmulo, Sylvia
dc.contributor.authorGirish, C P
dc.contributor.authorBhatnagar, Tarun
dc.contributor.authorChowdhury, Fahmida
dc.contributor.authorSyeda Mah-E-Muneer
dc.contributor.authorAraos Bralic, Rafael Ignacio
dc.contributor.authorMunita, Jose M.
dc.contributor.authorAcevedo, Johanna
dc.contributor.authorMahon, Garrett
dc.contributor.authorSmith, Rachel
dc.contributor.authorStyczynski, Ashley
dc.date.accessioned2026-08-18T22:17:27Z
dc.date.available2026-08-18T22:17:27Z
dc.date.issued2025
dc.description.abstractThe recognized burden of antimicrobial resistance (AR) is greatest in low- and middle-income countries (LMICs), but limitations in surveillance preclude accurate estimates of AR. We aimed to evaluate colonization in communities and hospitals across six LMICs for two clinically-important pathogens: extended-spectrum cephalosporin-resistant Enterobacterales (ESCrE) and carbapenem-resistant Enterobacterales (CRE). Participants in hospitals and communities provided rectal swabs or stool samples for ESCrE and CRE identification. Isolates recovered from selective agars underwent confirmatory identification and antibiotic susceptibility testing (AST) using VitekĀ® 2, MALDI-TOF, and/or disc diffusion testing. ESCrE and CRE were defined based on established breakpoints of phenotypic resistance to third-generation cephalosporins and carbapenems, respectively, to calculate prevalence of colonization. Community prevalence estimates were weighted to account for sampling design differences. A total of 10,139 participants across the 6 countries provided samples; 63% were females with a median age of 35 years (range: 0-99). Colonization with ESCrE in hospitals was high in all sites (range 34-84%). In communities, ESCrE colonization ranged from 22 to 77%. Prevalence of CRE colonization in hospitals ranged from 7 to 36% and in communities ranged from < 1 to 14%. These findings reveal a high burden of AR colonization in LMICs in both communities and hospitals. Cost-effective strategies to reduce AR colonization burden are needed in LMICs.
dc.description.versionVersiĆ³n Publicada
dc.identifier.citationParra G, Lautenbach E, Mosepele M, Mannathoko N, Gross R, Call DR, Ramay BM, Omulo S, Girish Kumar CP, Bhatnagar T, Chowdhury F, Mah-E-Muneer S, Araos R, Munita JM, Acevedo J, Mahon G, Smith RM, Styczynski A. Colonization with antibiotic resistant bacteria in communities and hospitals across six countries, including Bangladesh, Botswana, Chile, Guatemala, India, and Kenya. Sci Rep. 2025 Jul 1;15(1):21275. doi: 10.1038/s41598-025-94750-3
dc.identifier.doihttps://doi.org/10.1038/s41598-025-94750-3
dc.identifier.urihttps://hdl.handle.net/11447/11020
dc.language.isoen
dc.subjectAntimicrobial resistance
dc.subjectCOVID-19
dc.subjectColonization
dc.subjectEpidemiologic trends
dc.subjectSurveillance
dc.titleColonization with antibiotic resistant bacteria in communities and hospitals across six countries, including Bangladesh, Botswana, Chile, Guatemala, India, and Kenya
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceScientific reports
dspace.entity.typePublication
relation.isAuthorOfPublication69e40056-7a55-41b3-8a65-05aace0e07e3
relation.isAuthorOfPublicationec52b0bf-d0bc-4844-9531-eca4a65f2b8e
relation.isAuthorOfPublication525e6967-5802-4c1a-b67f-35abb11bf1f1
relation.isAuthorOfPublication.latestForDiscovery69e40056-7a55-41b3-8a65-05aace0e07e3

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