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Molecular Interplay Between Non-Coding RNAs and Connexins and Its Possible Role in Cancer

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dc.contributor.authorPerez Moreno, Pablo
dc.contributor.authorMuñoz, Juan
dc.contributor.authorRetamal, Mauricio A.
dc.date.accessioned2025-06-11T15:20:33Z
dc.date.available2025-06-11T15:20:33Z
dc.date.issued2025
dc.description.abstractNon-coding RNAs (ncRNAs) are sequences that do not encode for proteins and play key roles in different cellular processes, including cell proliferation and differentiation. On the other hand, connexins (Cxs) are transmembrane proteins that principally allow intercellular communication. In pathological conditions such as cancer, there is a deregulation in the expression and/or function of ncRNAs and Cxs, which in turn leads to an enhancement in the aggressive phenotype, such as a greater proliferative and invasive capacity. This suggests a plausible interplay between ncRNAs and Cxs. Based on that, this review aims to summarize the current knowledge regarding this relationship and to analyze how it may influence the development of aggressive traits in cancer cells and the clinicopathological features of cancer patients. Finally, we discuss the potential of ncRNAs and Cxs as promising clinical biomarkers for cancer diagnosis, prognosis, and therapeutic targeting. Keywords: cancer; connexins; non-coding RNAs.
dc.description.versionVersión Publicada
dc.identifier.citationPérez-Moreno P, Muñoz JP, Retamal MA. Molecular Interplay Between Non-Coding RNAs and Connexins and Its Possible Role in Cancer. Int J Mol Sci. 2025 Mar 12;26(6):2538. doi: 10.3390/ijms26062538
dc.identifier.doihttps://doi.org/10.3390/ijms26062538
dc.identifier.urihttps://hdl.handle.net/11447/10088
dc.language.isoen
dc.subjectCancer
dc.subjectConnexins
dc.subjectnon-coding RNAs
dc.titleMolecular Interplay Between Non-Coding RNAs and Connexins and Its Possible Role in Cancer
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceInternational journal of molecular sciences
dspace.entity.typePublication
relation.isAuthorOfPublicationd24481fe-ab73-4d4b-91bd-0eb3f120861a
relation.isAuthorOfPublication01e4a6fa-e55f-47c5-a1b6-383d5fc6f474
relation.isAuthorOfPublication.latestForDiscoveryd24481fe-ab73-4d4b-91bd-0eb3f120861a

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