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Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia

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dc.contributor.authorAlbasanz-Puig, Adaia
dc.contributor.authorDurà-Miralles, Xavier
dc.contributor.authorLaporte-Amargós, Júlia
dc.contributor.authorMussetti, Alberto
dc.contributor.authorRuiz-Camps, Isabel
dc.contributor.authorPuerta-Alcalde, Pedro
dc.contributor.authorAbdala, Edson
dc.contributor.authorOltolini, Chiara
dc.contributor.authorAkova, Murat
dc.contributor.authorMontejo ,José Miguel
dc.contributor.authorMalgorzata, Mikulska
dc.contributor.authorMartín-Dávila, Pilar
dc.contributor.authorHerrera, Fabián
dc.contributor.authorGasch, Oriol
dc.contributor.authorDrgona, Lubos
dc.contributor.authorPaz Morales, Hugo Manuel
dc.contributor.authorBrunel, Anne-Sophie
dc.contributor.authorGarcía, Estefanía
dc.contributor.authorIsler, Burcu
dc.contributor.authorKern, Winfried V.
dc.contributor.authorRetamar-Gentil, Pilar
dc.contributor.authorAguado, José María
dc.contributor.authorMontero, Milagros
dc.contributor.authorKanj, Souha S.
dc.contributor.authorSipahi, Oguz R.
dc.contributor.authorCalik, Sebnem
dc.contributor.authorMárquez-Gómez, Ignacio
dc.contributor.authorMarín, Jorge I.
dc.contributor.authorGomes, Marisa Z.R.
dc.contributor.authorHemmati, Philipp
dc.contributor.authorAraos Bralic, Rafael Ignacio
dc.contributor.authorPeghin, Magdalena
dc.contributor.authorPozo, José Luis del
dc.contributor.authorYáñez, Lucrecia
dc.contributor.authorTilley, Robert
dc.contributor.authorManzur, Adriana
dc.contributor.authorNovo, Andres
dc.contributor.authorPallarès, Natàlia
dc.contributor.authorBergas, Alba
dc.contributor.authorCarratalà, Jordi
dc.contributor.authorGudiol, Carlota
dc.contributor.authorThe Ironic Study Group
dc.date.accessioned2023-12-05T20:55:48Z
dc.date.available2023-12-05T20:55:48Z
dc.date.issued2022
dc.description.abstractTo assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate in neutropenic cancer patients with Pseudomonas aeruginosa (PA) bacteremic pneumonia. This was a multinational, retrospective cohort study of neutropenic onco-hematological patients with PA bloodstream infection (BSI) (2006−2018). The effect of appropriate empirical combination therapy, appropriate monotherapy and inappropriate empirical antibiotic therapy [IEAT] on 30-day case-fatality was assessed only in patients with PA bacteremic pneumonia. Among 1017 PA BSI episodes, pneumonia was the source of BSI in 294 (28.9%). Among those, 52 (17.7%) were caused by a multidrug-resistant (MDR) strain and 68 (23.1%) received IEAT, mainly when the infection was caused by an MDR strain [38/52 (73.1%) vs. 30/242 (12.4%); p < 0.001]. The 30-day case-fatality rate was higher in patients with PA bacteremic pneumonia than in those with PA BSI from other sources (55.1% vs. 31.4%; p < 0.001). IEAT was associated with increased 30-day case-fatality (aHR 1.44 [95%CI 1.01−2.03]; p = 0.042), whereas the use of appropriate combination empirical treatment was independently associated with improved survival (aHR 0.46 [95%CI 0.27−0.78]; p = 0.004). Appropriate empirical monotherapy was not associated with improved overall survival (aHR 1.25 [95%CI 0.76−2.05]; p = 0.39). Combination antibiotic empirical therapy should be administered promptly in febrile neutropenic patients with suspected pneumonia as the source of infection.
dc.description.versionVersión publicada
dc.format.extent14 p.
dc.identifier.citationAlbasanz-Puig, A.; Durà-Miralles, X.; Laporte-Amargós, J.; Mussetti, A.; Ruiz-Camps, I.; Puerta-Alcalde, P.; Abdala, E.; Oltolini, C.; Akova, M.; Montejo, J.M.; et al. Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia. Microorganisms 2022, 10, 733. https://doi.org/10.3390/ microorganisms10040733
dc.identifier.doihttps://doi.org/10.3390/ microorganisms10040733
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/8139
dc.language.isoen
dc.subjectPseudomonas aeruginosa
dc.subjectBloodstream infection
dc.subjectPneumonia
dc.subjectSeptic shock
dc.subjectNeutropenia
dc.titleEffect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia
dc.typeArticle
dcterms.abstractAcceso abierto
dcterms.sourceMicroorganisms
dspace.entity.typePublication
relation.isAuthorOfPublication69e40056-7a55-41b3-8a65-05aace0e07e3
relation.isAuthorOfPublication.latestForDiscovery69e40056-7a55-41b3-8a65-05aace0e07e3

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