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Cardiac function in critically ill patients with severe COVID: A prospective cross-sectional study in mechanically ventilated patients

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dc.contributor.authorValenzuela, Emilio Daniel
dc.contributor.authorMercado, Pablo
dc.contributor.authorPairumani, Ronald
dc.contributor.authorMedel, Juan Nicolás
dc.contributor.authorPetruska, Edward
dc.contributor.authorUgalde, Diego
dc.contributor.authorMorales, Felipe
dc.contributor.authorEisen, Daniela
dc.contributor.authorAraya, Carla
dc.contributor.authorMontoya, Jorge
dc.contributor.authorGonzález, Alejandra
dc.contributor.authorRovegno, Maximiliano
dc.contributor.authorRamirez, Javier
dc.contributor.authorAguilera, Javiera
dc.contributor.authorHernández, Glenn
dc.contributor.authorBruhn, Alejandro
dc.contributor.authorSlama, Michel
dc.contributor.authorBakker, Jan
dc.date.accessioned2023-12-07T18:36:50Z
dc.date.available2023-12-07T18:36:50Z
dc.date.issued2022
dc.description.abstractPurpose: To evaluate cardiac function in mechanically ventilated patients with COVID-19. Materials and methods: Prospective, cross-sectional multicenter study in four university-affiliated hospitals in Chile. All consecutive patients with COVID-19 ARDS requiring mechanical ventilation admitted between April and July 2020 were included. We performed systematic transthoracic echocardiography assessing right and left ventricular function within 24 h of intubation. Results: 140 patients aged 57 ± 11, 29% female were included. Cardiac output was 5.1 L/min [IQR 4.5-6.2] and 86% of the patients required norepinephrine. ICU mortality was 29% (40 patients). Fifty-four patients (39%) exhibited right ventricle dilation out of whom 20 patients (14%) exhibited acute cor pulmonale (ACP). Eight out of the twenty patients with ACP exhibited pulmonary embolism (40%). Thirteen patients (9%) exhibited left ventricular systolic dysfunction (ejection fraction <45%). In the multivariate analysis acute cor pulmonale and PaO2/FiO2 ratio were independent predictors of ICU mortality. Conclusions: Right ventricular dilation is highly prevalent in mechanically ventilated patients with COVID-19 ARDS. Acute cor pulmonale was associated with reduced pulmonary function and, in only 40% of patients, with co-existing pulmonary embolism. Acute cor pulmonale is an independent risk factor for ICU mortality.
dc.description.versionVersión publicada
dc.format.extent8 p.
dc.identifier.citationValenzuela ED, Mercado P, Pairumani R, Medel JN, Petruska E, Ugalde D, Morales F, Eisen D, Araya C, Montoya J, Gonzalez A, Rovegno M, Ramirez J, Aguilera J, Hernández G, Bruhn A, Slama M, Bakker J. Cardiac function in critically ill patients with severe COVID: A prospective cross-sectional study in mechanically ventilated patients. J Crit Care. 2022 Dec;72:154166. doi: 10.1016/j.jcrc.2022.154166.
dc.identifier.doihttps://doi.org/10.1016/j.jcrc.2022.154166
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/8155
dc.language.isoen
dc.subjectAcute cor pulmonale
dc.subjectCOVID-19
dc.subjectCardiac function
dc.subjectMechanical ventilation
dc.subjectMortality
dc.subjectRight ventricular dilation
dc.titleCardiac function in critically ill patients with severe COVID: A prospective cross-sectional study in mechanically ventilated patients
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceJournal of Critical Care
dspace.entity.typePublication

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