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Multicenter analysis of neutrophil extracellular trap dysregulation in adult and pediatric COVID-19

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dc.contributor.authorCarmona, Carmelo
dc.contributor.authorZhang, Yu
dc.contributor.authorDobbs, Kerry
dc.contributor.authorMarkowitz, Tovah
dc.contributor.authorDalgard, Clifton
dc.contributor.authorOler, Andrew
dc.contributor.authorClaybaugh, Dillon
dc.contributor.authorDraper, Deborah
dc.contributor.authorTruong, Meng
dc.contributor.authorDelmonte, Ottavia
dc.contributor.authorLicciardi, Francesco
dc.contributor.authorRamenghi, Ugo
dc.contributor.authorCrescenzio, Nicoletta
dc.contributor.authorImberti, Luisa
dc.contributor.authorSottini, Alessandra
dc.contributor.authorQuaresima, Virginia
dc.contributor.authorFiorini, Chiara
dc.contributor.authorDiscepolo, Valentina
dc.contributor.authorLo Vecchio, Andrea
dc.contributor.authorGuarino, Alfredo
dc.contributor.authorPierri, Luca
dc.contributor.authorCatzola, Andrea
dc.contributor.authorBiondi, Andrea
dc.contributor.authorBonfanti, Paolo
dc.contributor.authorPoli, Cecilia
dc.contributor.authorEspinosa, Yasmin
dc.contributor.authorAstudillo, Camila
dc.contributor.authorRey, Emma
dc.contributor.authorVial, Cecilia
dc.contributor.authorDe la Cruz, Javiera
dc.contributor.authorGonzález, Ricardo
dc.contributor.authorPinera, Cecilia
dc.contributor.authorMays, Jacqueline
dc.contributor.authorNg, Ashley
dc.contributor.authorPlatt, Andrew
dc.contributor.authorNIH COVID Autopsy Consortium
dc.contributor.authorCOVID STORM Clinicians
dc.contributor.authorDrolet, Beth
dc.contributor.authorMoon, John
dc.contributor.authorCowen, Edward
dc.contributor.authorKenney, Heather
dc.contributor.authorWeber, Sarah
dc.contributor.authorCastagnoli, Riccardo
dc.contributor.authorMagliocco, Mary
dc.contributor.authorStack, Michael
dc.contributor.authorMontealegre, Gina
dc.contributor.authorBarron, Karyl
dc.contributor.authorFink, Danielle
dc.contributor.authorKuhns, Douglas
dc.contributor.authorHewitt, Stephen
dc.contributor.authorArkin, Lisa
dc.contributor.authorChertow, Daniel
dc.contributor.authorSu, Helen
dc.contributor.authorNotarangelo, Luigi
dc.contributor.authorKaplan, Mariana
dc.date.accessioned2023-04-27T20:11:51Z
dc.date.available2023-04-27T20:11:51Z
dc.date.issued2022
dc.description.abstractDysregulation in neutrophil extracellular trap (NET) formation and degradation may play a role in the pathogenesis and severity of COVID-19; however, its role in the pediatric manifestations of this disease, including multisystem inflammatory syndrome in children (MIS-C) and chilblain-like lesions (CLLs), otherwise known as "COVID toes," remains unclear. Studying multinational cohorts, we found that, in CLLs, NETs were significantly increased in serum and skin. There was geographic variability in the prevalence of increased NETs in MIS-C, in association with disease severity. MIS-C and CLL serum samples displayed decreased NET degradation ability, in association with C1q and G-actin or anti-NET antibodies, respectively, but not with genetic variants of DNases. In adult COVID-19, persistent elevations in NETs after disease diagnosis were detected but did not occur in asymptomatic infection. COVID-19-affected adults displayed significant prevalence of impaired NET degradation, in association with anti-DNase1L3, G-actin, and specific disease manifestations, but not with genetic variants of DNases. NETs were detected in many organs of adult patients who died from COVID-19 complications. Infection with the Omicron variant was associated with decreased NET levels when compared with other SARS-CoV-2 strains. These data support a role for NETs in the pathogenesis and severity of COVID-19 in pediatric and adult patients.
dc.description.versionVersión Publicada
dc.identifier.citationCarmona-Rivera C, Zhang Y, Dobbs K, Markowitz TE, Dalgard CL, Oler AJ, Claybaugh DR, Draper D, Truong M, Delmonte OM, Licciardi F, Ramenghi U, Crescenzio N, Imberti L, Sottini A, Quaresima V, Fiorini C, Discepolo V, Lo Vecchio A, Guarino A, Pierri L, Catzola A, Biondi A, Bonfanti P, Poli Harlowe MC, Espinosa Y, Astudillo C, Rey-Jurado E, Vial C, de la Cruz J, Gonzalez R, Pinera C, Mays JW, Ng A, Platt A; NIH COVID Autopsy Consortium; COVID STORM Clinicians; Drolet B, Moon J, Cowen EW, Kenney H, Weber SE, Castagnoli R, Magliocco M, Stack MA, Montealegre G, Barron K, Fink DL, Kuhns DB, Hewitt SM, Arkin LM, Chertow DS, Su HC, Notarangelo LD, Kaplan MJ. Multicenter analysis of neutrophil extracellular trap dysregulation in adult and pediatric COVID-19. JCI Insight. 2022 Aug 22;7(16):e160332. doi: 10.1172/jci.insight.160332
dc.identifier.doihttps://doi.org/10.1172/jci.insight.160332
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7422
dc.language.isoen
dc.subjectInfectious disease
dc.subjectInflammation
dc.subjectNeutrophils
dc.titleMulticenter analysis of neutrophil extracellular trap dysregulation in adult and pediatric COVID-19
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.accessRightsAcceso Abierto
dcterms.sourceJCI insight
dspace.entity.typePublication

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