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Administration of Secretome Derived from Human Mesenchymal Stem Cells Induces Hepatoprotective Effects in Models of Idiosyncratic Drug-Induced Liver Injury Caused by Amiodarone or Tamoxifen

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dc.contributor.authorHuang, Ya-Lin
dc.contributor.authorDe Gregorio, Cristian
dc.contributor.authorSilva, Verónica
dc.contributor.authorElorza, Álvaro
dc.contributor.authorLéniz, Patricio
dc.contributor.authorAliaga, Víctor
dc.contributor.authorMaracaja, Vinicius
dc.contributor.authorBudini, Mauricio
dc.contributor.authorEzquer, Fernando
dc.contributor.authorEzquer, Marcelo
dc.date.accessioned2024-05-07T18:50:37Z
dc.date.available2024-05-07T18:50:37Z
dc.date.issued2023
dc.description.abstractDrug-induced liver injury (DILI) is one of the leading causes of acute liver injury. While many factors may contribute to the susceptibility to DILI, obese patients with hepatic steatosis are particularly prone to suffer DILI. The secretome derived from mesenchymal stem cell has been shown to have hepatoprotective effects in diverse in vitro and in vivo models. In this study, we evaluate whether MSC secretome could improve DILI mediated by amiodarone (AMI) or tamoxifen (TMX). Hepatic HepG2 and HepaRG cells were incubated with AMI or TMX, alone or with the secretome of MSCs obtained from human adipose tissue. These studies demonstrate that coincubation of AMI or TMX with MSC secretome increases cell viability, prevents the activation of apoptosis pathways, and stimulates the expression of priming phase genes, leading to higher proliferation rates. As proof of concept, in a C57BL/6 mouse model of hepatic steatosis and chronic exposure to AMI, the MSC secretome was administered endovenously. In this study, liver injury was significantly attenuated, with a decrease in cell infiltration and stimulation of the regenerative response. The present results indicate that MSC secretome administration has the potential to be an adjunctive cell-free therapy to prevent liver failure derived from DILI caused by TMX or AMI.
dc.description.versionPublicada
dc.identifier.citationHuang YL, De Gregorio C, Silva V, Elorza ÁA, Léniz P, Aliaga-Tobar V, Maracaja-Coutinho V, Budini M, Ezquer F, Ezquer M. Administration of Secretome Derived from Human Mesenchymal Stem Cells Induces Hepatoprotective Effects in Models of Idiosyncratic Drug-Induced Liver Injury Caused by Amiodarone or Tamoxifen. Cells. 2023 Feb 16;12(4):636. doi: 10.3390/cells12040636
dc.identifier.doihttps://doi.org/10.3390/cells12040636
dc.identifier.urihttps://hdl.handle.net/11447/8720
dc.language.isoen
dc.subjectAmiodarone
dc.subjectCell free therapy
dc.subjectDrug-induced liver injury
dc.subjectHepatic regeneration
dc.subjectTamoxifen
dc.titleAdministration of Secretome Derived from Human Mesenchymal Stem Cells Induces Hepatoprotective Effects in Models of Idiosyncratic Drug-Induced Liver Injury Caused by Amiodarone or Tamoxifen
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceCells
dspace.entity.typePublication
relation.isAuthorOfPublicationc74766c7-dad8-4d11-b35d-01da0664f3da
relation.isAuthorOfPublication9cd4a8e6-6ba1-4344-80a2-45c260864d4c
relation.isAuthorOfPublication.latestForDiscoveryc74766c7-dad8-4d11-b35d-01da0664f3da

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