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Multimodal Neurocognitive Markers of Naturalistic Discourse Typify Diverse Neurodegenerative Diseases

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dc.contributor.authorBirba, Agustina
dc.contributor.authorFittipaldi, Sol
dc.contributor.authorCediel Escobar, Judith C.
dc.contributor.authorGonzalez Campo, Cecilia
dc.contributor.authorLegaz, Agustina
dc.contributor.authorGaliani, Agostina
dc.contributor.authorDíaz Rivera, Mariano N.
dc.contributor.authorMartorell Caro, Miquel
dc.contributor.authorAlifano, Florencia
dc.contributor.authorPiña-Escudero, Stefanie D.
dc.contributor.authorCardona, Juan Felipe
dc.contributor.authorNeely, Alejandra
dc.contributor.authorForno, Gonzalo
dc.contributor.authorCarpinella , Mariela
dc.contributor.authorSlachevsky Chonchol, Andrea
dc.contributor.authorSerrano, Cecilia
dc.contributor.authorSedeño, Lucas
dc.contributor.authorIbáñez, Agustín
dc.contributor.authorGarcía, Adolfo M.
dc.date.accessioned2024-06-12T14:37:01Z
dc.date.available2024-06-12T14:37:01Z
dc.date.issued2022
dc.description.abstractNeurodegeneration has multiscalar impacts, including behavioral, neuroanatomical, and neurofunctional disruptions. Can disease-differential alterations be captured across such dimensions using naturalistic stimuli? To address this question, we assessed comprehension of four naturalistic stories, highlighting action, nonaction, social, and nonsocial events, in Parkinson's disease (PD) and behavioral variant frontotemporal dementia (bvFTD) relative to Alzheimer's disease patients and healthy controls. Text-specific correlates were evaluated via voxel-based morphometry, spatial (fMRI), and temporal (hd-EEG) functional connectivity. PD patients presented action-text deficits related to the volume of action-observation regions, connectivity across motor-related and multimodal-semantic hubs, and frontal hd-EEG hypoconnectivity. BvFTD patients exhibited social-text deficits, associated with atrophy and spatial connectivity patterns along social-network hubs, alongside right frontotemporal hd-EEG hypoconnectivity. Alzheimer's disease patients showed impairments in all stories, widespread atrophy and spatial connectivity patterns, and heightened occipitotemporal hd-EEG connectivity. Our framework revealed disease-specific signatures across behavioral, neuroanatomical, and neurofunctional dimensions, highlighting the sensitivity and specificity of a single naturalistic task. This investigation opens a translational agenda combining ecological approaches and multimodal cognitive neuroscience for the study of neurodegeneration.
dc.description.versionVersión publicada
dc.format.extent15 p.
dc.identifier.citationBirba, A., Fittipaldi, S., Cediel Escobar, J. C., Gonzalez Campo, C., Legaz, A., Galiani, A., Díaz Rivera, M. N., Martorell Caro, M., Alifano, F., Piña-Escudero, S. D., Cardona, J. F., Neely, A., Forno, G., Carpinella, M., Slachevsky, A., Serrano, C., Sedeño, L., Ibáñez, A., & García, A. M. (2022). Multimodal Neurocognitive Markers of Naturalistic Discourse Typify Diverse Neurodegenerative Diseases. Cerebral cortex (New York, N.Y. : 1991), 32(16), 3377–3391.
dc.identifier.doihttps://doi.org/10.1093/cercor/bhab421
dc.identifier.issn1460-2199
dc.identifier.urihttps://hdl.handle.net/11447/9073
dc.language.isoen
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectEmbodied cognition
dc.subjectFMRI/hd-EEG functional connectivity
dc.subjectNaturalistic texts
dc.subjectNeurodegeneration
dc.subjectVoxel-based morphometry
dc.titleMultimodal Neurocognitive Markers of Naturalistic Discourse Typify Diverse Neurodegenerative Diseases
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceCerebral Cortex
dspace.entity.typePublication
relation.isAuthorOfPublicatione25c3d3e-63b5-4e04-951a-12a4989aa772
relation.isAuthorOfPublication.latestForDiscoverye25c3d3e-63b5-4e04-951a-12a4989aa772

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