Publication:
Source-based morphometry reveals structural brain pattern abnormalities in 22q11.2 deletion syndrome

Simple item page
dc.contributor.authorRepetto, Gabriela
dc.contributor.authorGe, Ruiyang
dc.contributor.authorChing, Christopher
dc.contributor.authorBassett, Anne
dc.contributor.authorKushan, Leila
dc.contributor.authorAntshe, Kevin
dc.contributor.authorVan Amelsvoort, Therese
dc.contributor.authorBakker, Geor
dc.contributor.authorButcher, Nancy
dc.contributor.authorCampbell, Linda
dc.contributor.authorChow, Eva
dc.contributor.authorCraig, Michael
dc.contributor.authorCrossley, Nicolas
dc.contributor.authorCunningham, Adam
dc.contributor.authorDaly, Eileen
dc.contributor.authorDoherty, Joanne
dc.contributor.authorDurdle, Courtney
dc.contributor.authorEmanuel, Beverly
dc.contributor.authorFiksinski, Ania
dc.contributor.authorForsyth, Jennifer
dc.contributor.authorFremont, Wanda
dc.contributor.authorGoodrich-Hunsaker, Naomi
dc.contributor.authorGudbrandsen, Maria
dc.contributor.authorGur, Raquel
dc.contributor.authorJalbrzikowski, Maria
dc.contributor.authorKates, Wendy
dc.contributor.authorLin, Amy
dc.contributor.authorLinden, David
dc.contributor.authorMcCabe, Kathryn
dc.contributor.authorMcDonald, Donna
dc.contributor.authorMoss, Hayley
dc.contributor.authorMurphy, Declan
dc.contributor.authorMurphy, Kieran
dc.contributor.authorOwen, Michael
dc.contributor.authorVillalon, Julio
dc.contributor.authorRoalf, David
dc.contributor.authorRuparel, Kosha
dc.contributor.authorSchmitt, J. Eric
dc.contributor.authorSchuite, Sanne
dc.contributor.authorAngkustsiri, Kathleen
dc.date.accessioned2024-03-11T15:28:57Z
dc.date.available2024-03-11T15:28:57Z
dc.date.issued2024
dc.descriptionSun, Daqiang; Vajdi, Ariana; Van den Bree, Marianne; Vorstman, Jacob; Thompson, Paul; Vila, Fidel; Bearden, Carrie.
dc.description.abstract22q11.2 deletion syndrome (22q11DS) is the most frequently occurring microdeletion in humans. It is associated with a significant impact on brain structure, including prominent reductions in gray matter volume (GMV), and neuropsychiatric manifestations, including cognitive impairment and psychosis. It is unclear whether GMV alterations in 22q11DS occur according to distinct structural patterns. Then, 783 participants (470 with 22q11DS: 51% females, mean age [SD] 18.2 [9.2]; and 313 typically developing [TD] controls: 46% females, mean age 18.0 [8.6]) from 13 datasets were included in the present study. We segmented structural T1-weighted brain MRI scans and extracted GMV images, which were then utilized in a novel source-based morphometry (SBM) pipeline (SS-Detect) to generate structural brain patterns (SBPs) that capture co-varying GMV. We investigated the impact of the 22q11.2 deletion, deletion size, intelligence quotient, and psychosis on the SBPs. Seventeen GMV-SBPs were derived, which provided spatial patterns of GMV covariance associated with a quantitative metric (i.e., loading score) for analysis. Patterns of topographically widespread differences in GMV covariance, including the cerebellum, discriminated individuals with 22q11DS from healthy controls. The spatial extents of the SBPs that revealed disparities between individuals with 22q11DS and controls were consistent with the findings of the univariate voxel-based morphometry analysis. Larger deletion size was associated with significantly lower GMV in frontal and occipital SBPs; however, history of psychosis did not show a strong relationship with these covariance patterns. 22q11DS is associated with distinct structural abnormalities captured by topographical GMV covariance patterns that include the cerebellum. Findings indicate that structural anomalies in 22q11DS manifest in a nonrandom manner and in distinct covarying anatomical patterns, rather than a diffuse global process. These SBP abnormalities converge with previously reported cortical surface area abnormalities, suggesting disturbances of early neurodevelopment as the most likely underlying mechanism.
dc.description.versionVersion Aceptada
dc.description.versionAceptada
dc.identifier.citationGe R, Ching CRK, Bassett AS, Kushan L, Antshel KM, van Amelsvoort T, Bakker G, Butcher NJ, Campbell LE, Chow EWC, Craig M, Crossley NA, Cunningham A, Daly E, Doherty JL, Durdle CA, Emanuel BS, Fiksinski A, Forsyth JK, Fremont W, Goodrich-Hunsaker NJ, Gudbrandsen M, Gur RE, Jalbrzikowski M, Kates WR, Lin A, Linden DEJ, McCabe KL, McDonald-McGinn D, Moss H, Murphy DG, Murphy KC, Owen MJ, Villalon-Reina JE, Repetto GM, Roalf DR, Ruparel K, Schmitt JE, Schuite-Koops S, Angkustsiri K, Sun D, Vajdi A, van den Bree M, Vorstman J, Thompson PM, Vila-Rodriguez F, Bearden CE. Source-based morphometry reveals structural brain pattern abnormalities in 22q11.2 deletion syndrome. Hum Brain Mapp. 2024 Jan;45(1):e26553. doi: 10.1002/hbm.26553
dc.identifier.doihttps://doi.org/10.1002/hbm.26553
dc.identifier.urihttps://hdl.handle.net/11447/8514
dc.language.isoen
dc.subject22q11 deletion syndrome
dc.subjectGray matter volume
dc.subjectMagnetic resonnance imaging
dc.subjectSource-based morphometry
dc.titleSource-based morphometry reveals structural brain pattern abnormalities in 22q11.2 deletion syndrome
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceHuman brain mapping
dspace.entity.typePublication
relation.isAuthorOfPublication98c75303-d87e-4c17-9d27-d9d710229223
relation.isAuthorOfPublication.latestForDiscovery98c75303-d87e-4c17-9d27-d9d710229223

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Source-based morphometry reveals structural brain pattern.pdf
Size:
11.03 MB
Format:
Adobe Portable Document Format
Description:
Texto Completo
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
347 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services