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Population attributable fraction of modifiable risk factors for dementia in Chile

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dc.contributor.authorVergara, Rodrigo
dc.contributor.authorZitko, Pedro
dc.contributor.authorSlachevsky, Andrea
dc.contributor.authorSan Martin, Consuelo
dc.contributor.authorDelgado, Carolina
dc.date.accessioned2023-07-11T14:50:38Z
dc.date.available2023-07-11T14:50:38Z
dc.date.issued2022
dc.description.abstractIntroduction: Projected dementia incidence in Latin America and the Caribbean for the next decades is overwhelming. Access to local data, stratified by sex, is imperative for planning precise dementia-prevention strategies. Methods: We analyzed the individual and overall weighted population attributable fraction (PAF) of nine modifiable risk factors for dementia, in dementia-free subjects ≥45-years-old, using the 2016-2017 Chilean National Health Survey. Results: The overall weighted PAF for modifiable risk factors was 45.8% (42.2% to 49.3%). Variables with the highest PAF were lower education, high blood pressure, hearing loss, and obesity. Women showed a greater overall weighted PAF: 50.7% (45.3% to -56.1%), compared to men: 40.2% (35.4% to 45.0%), driven by a higher PAF for physical inactivity and depression in women. Discussion: The PAF for modifiable risk factors for dementia in Chile is higher than in previous world reports, due to a greater prevalence of cardiovascular risk factors. Women have a higher potential for dementia prevention. Highlights: The proportion of dementia associated to modifiable risk factors in Chile is 45.8%.The main modifiable risk factors are high blood pressure, obesity, and hearing loss.Women had a greater prevalence of physical inactivity and depression than men.Chile had a greater prevalence of metabolic risk factors than other world regions.
dc.description.versionVersión Publicada
dc.identifier.citationVergara RC, Zitko P, Slachevsky A, San Martin C, Delgado C. Population attributable fraction of modifiable risk factors for dementia in Chile. Alzheimers Dement (Amst). 2022 Feb 23;14(1):e12273. doi: 10.1002/dad2.12273
dc.identifier.doihttps://doi.org/10.1002/dad2.12273
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7690
dc.language.isoen
dc.subjectLatin America and the Caribbean
dc.subjectCardiovascular
dc.subjectDementia
dc.subjectDepression
dc.subjectHypertension
dc.subjectMidlife
dc.subjectModifiable risk factors
dc.subjectObesity
dc.subjectPrevention
dc.subjectPhysical inactivity
dc.subjectPopulation attributable fraction
dc.titlePopulation attributable fraction of modifiable risk factors for dementia in Chile
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceAlzheimer's & dementia : diagnosis, assessment & disease monitoring
dspace.entity.typePublication

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