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Longitudinal study of wound healing status and bacterial colonisation of Staphylococcus aureus and Corynebacterium diphtheriae in epidermolysis bullosa patients

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dc.contributor.authorFuentes, Ignacia
dc.contributor.authorJoao, María
dc.contributor.authorMorandé, Pilar
dc.contributor.authorVarela, Carmen
dc.contributor.authorOrostica, Karen
dc.contributor.authorAcevedo, Francisco
dc.contributor.authorRebolledo, Boris
dc.contributor.authorArancibia, Esteban
dc.contributor.authorPorte, Lorena
dc.contributor.authorPalisson, Francis
dc.date.accessioned2023-03-31T13:57:28Z
dc.date.available2023-03-31T13:57:28Z
dc.date.issued2022
dc.description.abstractEpidermolysis bullosa (EB) is an inherited disorder characterised by skin fragility and the appearance of blisters and wounds. Patient wounds are often colonised or infected with bacteria, leading to impaired healing, pain and high risk of death by sepsis. Little is known about the impact of bacterial composition and susceptibility in wound resolution, and there is a need for longitudinal studies to understand healing outcomes with different types of bacterial colonisation. A prospective longitudinal study of 70 wounds from 15 severe EB patients (Junctional and Recessive Dystrophic EB) from Chile. Wounds were selected independently of their infected status. Wound cultures, including bacterial species identification, composition and Staphylococcus aureus (SA) antibiotic susceptibility were registered. Wounds were separated into categories according to their healing capacity, recognising chronic, and healing wounds. Hundred-one of the 102 wound cultures were positive for bacterial growth. From these, 100 were SA-positive; 31 were resistant to Ciprofloxacin (31%) and only seven were methicillin-resistant SA (7%). Ciprofloxacin-resistant SA was found significantly predominant in chronic wounds (**P < .01). Interestingly, atoxigenic Corynebacterium diphtheriae (CD) was identified and found to be the second most abundant recovered bacteria (31/101), present almost always in combination with SA (30/31). CD was only found in Recessive Dystrophic EB patients and not related to wound chronicity. Other less frequent bacterial species found included Pseudomonas aeruginosa, Streptococus spp. and Proteus spp. Infection was negatively associated with the healing status of wounds.
dc.description.versionVersión aceptada
dc.identifier.citationFuentes I, Yubero MJ, Morandé P, Varela C, Oróstica K, Acevedo F, Rebolledo-Jaramillo B, Arancibia E, Porte L, Palisson F. Longitudinal study of wound healing status and bacterial colonisation of Staphylococcus aureus and Corynebacterium diphtheriae in epidermolysis bullosa patients. Int Wound J. 2023 Mar;20(3):774-783. doi: 10.1111/iwj.13922
dc.identifier.doihttps://doi.org/10.1111/iwj.13922
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7208
dc.language.isoen
dc.subjectCorynebacterium diphtheriae
dc.subjectEpidermolysis bullosa
dc.subjectSkin diseases
dc.subjectStaphylococcus aureus
dc.subjectWound healing
dc.titleLongitudinal study of wound healing status and bacterial colonisation of Staphylococcus aureus and Corynebacterium diphtheriae in epidermolysis bullosa patients
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceInternational wound journal
dspace.entity.typePublication

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