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Functional Dizziness as a Spatial Cognitive Dysfunction

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dc.contributor.authorBreinbauer, Hayo
dc.contributor.authorStecher, Ximena
dc.contributor.authorZamorano, Francisco
dc.contributor.authorBilleke, Pablo
dc.contributor.authorArévalo, Camilo
dc.contributor.authorVillarroel, Karen
dc.contributor.authorLavin, Claudio
dc.contributor.authorFaúndez, Felipe
dc.contributor.authorGarrido, Rosario
dc.contributor.authorAlarcón, Kevin
dc.contributor.authorDelano, Paul
dc.date.accessioned2024-03-06T15:16:12Z
dc.date.available2024-03-06T15:16:12Z
dc.date.issued2024
dc.description.abstract(1) Background: Persistent postural-perceptual dizziness (PPPD) is a common chronic dizziness disorder with an unclear pathophysiology. It is hypothesized that PPPD may involve disrupted spatial cognition processes as a core feature. (2) Methods: A cohort of 19 PPPD patients underwent psycho-cognitive testing, including assessments for anxiety, depression, memory, attention, planning, and executive functions, with an emphasis on spatial navigation via a virtual Morris water maze. These patients were compared with 12 healthy controls and 20 individuals with other vestibular disorders but without PPPD. Vestibular function was evaluated using video head impulse testing and vestibular evoked myogenic potentials, while brain magnetic resonance imaging was used to exclude confounding pathology. (3) Results: PPPD patients demonstrated unique impairments in allocentric spatial navigation (as evidenced by the virtual Morris water maze) and in other high-demand visuospatial cognitive tasks that involve executive functions and planning, such as the Towers of London and Trail Making B tests. A factor analysis highlighted spatial navigation and advanced visuospatial functions as being central to PPPD, with a strong correlation to symptom severity. (4) Conclusions: PPPD may broadly impair higher cognitive functions, especially in spatial cognition. We discuss a disruption in the creation of enriched cognitive spatial maps as a possible pathophysiology for PPPD
dc.description.versionPublicada
dc.identifier.citationBreinbauer, H.A.; Arévalo-Romero, C.; Villarroel, K.; Lavin, C.; Faúndez, F.; Garrido, R.; Alarcón, K.; Stecher, X.; Zamorano, F.; Billeke, P.; et al. Functional Dizziness as a Spatial Cognitive Dysfunction. Brain Sci. 2024, 14, 16. https:// doi.org/10.3390/brainsci14010016
dc.identifier.doihttps://doi.org/10.3390/brainsci14010016
dc.identifier.urihttps://hdl.handle.net/11447/8487
dc.language.isoen
dc.subjectPersistent postural perceptual dizziness
dc.subjectFunctional dizziness
dc.subjectSpatial navigation
dc.subjectSpatial cognition
dc.subjectFunctional neurological disorder
dc.subjectChronic dizziness
dc.subjectChronic vertigo
dc.titleFunctional Dizziness as a Spatial Cognitive Dysfunction
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceBrain sciences
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery9b4a39a8-86bb-44c6-b336-bd5f761a08da

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