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Comprehensive in‑silico molecular analysis of early‑onset gastric cancer identifies novel genes implicated in disease characterization and progression (Review)

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dc.contributor.authorGómez‑Valenzuela, Fernán
dc.contributor.authorSilva, Ian
dc.contributor.authorRetamal, Ignacio N.
dc.contributor.authorGarcía‑Bloj, Benjamín
dc.contributor.authorDe Mayo Glasser, Tomás
dc.contributor.authorMuñoz‑Medel, Matías
dc.contributor.authorGómez, Alex
dc.contributor.authorSan Martín, Cristopher
dc.contributor.authorSánchez, Carolina
dc.contributor.authorPinto, Felipe
dc.contributor.authorAravena, Paola
dc.contributor.authorSabioncello, Andrea C.
dc.contributor.authorGarrido Villanueva, Marcelo
dc.contributor.authorSigler Chávez, Fernado
dc.contributor.authorCorvalán, Ignacio
dc.contributor.authorBarrios, Henry
dc.contributor.authorErpel, José M.
dc.contributor.authorManque, Patricio A.
dc.contributor.authorGodoy, Juan A.
dc.contributor.authorGarrido, Marcelo
dc.date.accessioned2026-07-30T21:57:40Z
dc.date.available2026-07-30T21:57:40Z
dc.date.issued2025
dc.description.abstractGastric cancer, a prevalent and fatal form of cancer worldwide, is manifested at different age ranges during the lifespan. Approximately one‑third of newly diagnosed gastric cancer cases are early‑onset gastric cancer (EO‑GC), which affects individuals under the age of 50 years. EO‑GC tends to be more aggressive than late‑onset gastric cancer (L‑GC), with a faster and multifocal disease progression. Furthermore, EO‑GC is associated with early metastatic disease. Recent research has underscored the need for a deeper understanding of EO‑GC that promotes therapeutic approaches specific to EO‑GC. The present study determined the main transcrip‑tomic differences between EO‑GC and L‑GC. Transcriptomic expression data from The Cancer Genome Atlas‑Stomach Adenocarcinoma were explored to elucidate whether age is associated with a specific genomic expression pattern and is associated with gastric cancer. Subsequently, a differential gene expression analysis of the EO‑GC vs. L‑GC groups was performed, providing new insights into EO‑GC gene expression characteristics and their association with survival outcomes. Furthermore, the study focused on whether the influence of representative gene expression in EO‑GC cases (KLHL4, MAGEL2, CYP8B1, RNLS, CLDN6, MIOX, PNMA5 and ACTL8 genes) may be associated with its aggressive phenotype and methylation profiles of these patients. In this review, the necessity of incorporating age as a crucial element in understanding the disparities in outcomes for EO‑GC cases in public datasets was discussed. Furthermore, this insight may be useful for targeted early personalized clinical interventions to improve patient prognosis and survival rates in EO‑GC cases.
dc.description.versionVersión aceptada
dc.format.extent20 p.
dc.identifier.citationGómez-Valenzuela F, Silva I, Retamal IN, García-Bloj B, De Mayo Glasser T, Muñoz-Medel M, Gómez A, San Martín C, Sánchez C, Pinto F, Aravena P, Sabioncello AC, Garrido Villanueva M, Sigler Chávez F, Corvalán I, Barrios H, Erpel JM, Manque PA, Godoy JA, Garrido M. Comprehensive in‑silico molecular analysis of early‑onset gastric cancer identifies novel genes implicated in disease characterization and progression (Review). Oncol Rep. 2025 Aug;54(2):98. doi: 10.3892/or.2025.8931.
dc.identifier.doihttps://doi.org/10.3892/or.2025.8931
dc.identifier.urihttps://hdl.handle.net/11447/10942
dc.language.isoen
dc.subjectGastric cancer
dc.subjectEarly‑onset gastric cancer
dc.subjectDifferentially expressed gene
dc.titleComprehensive in‑silico molecular analysis of early‑onset gastric cancer identifies novel genes implicated in disease characterization and progression (Review)
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceOncology Reports
dspace.entity.typePublication

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