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IL-10 and IL-6/IL-10 as predictive biomarkers for treatment response in non-infectious uveitis

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dc.contributor.authorValenzuela, Rodrigo
dc.contributor.authorVega, Fabian
dc.contributor.authorElizalde, Nathaly
dc.contributor.authorFlores, Ivan
dc.contributor.authorRojas, Felipe
dc.contributor.authorGoecke, Annelise
dc.contributor.authorCuitino , Loreto
dc.contributor.authorUrzúa, Cristhian Alejandro
dc.date.accessioned2026-09-21T20:33:13Z
dc.date.available2026-09-21T20:33:13Z
dc.date.issued2025
dc.description.abstractUveitis, a group of heterogeneous diseases causing ocular inflammation, is a major contributor to vision loss globally. While systemic corticosteroids (CS) are the mainstay treatment, identifying CS-refractory patients remains a significant challenge. This study aimed to explore cytokine expression and Glucocorticoid Receptor (GR) levels as biomarkers for the early detection of CS-refractory cases in non-infectious uveitis. We assayed blood samples from 19 patients with non-infectious uveitis, for the expression of IL-6, IL-17A, TNF-α, IL-10 and GRα. The cohort included 11 refractory and 8 sensitive patients, categorized based on their clinical response to corticosteroids (prednisone 1 mg/kg/day). Blood draws were conducted at three time points (at baseline, day 7- and day 14 after CS initiation), and peripheral blood mononuclear cells (PBMCs) were isolated to measure cytokine and GRα transcript levels via real-time PCR. The expression levels of GRα and cytokines IL-6, IL-17A and TNF-α did not show significant changes between CS-sensitive and CS-refractory patients on the different days of treatment. However, IL-10 expression levels as the day14-to-day7 ratio were significantly higher in patients sensitive to CS therapy. A higher day14-to-day7 ratio was also found for the IL-6/IL-10, IL-17A/IL-10 and GRα/IL-10 ratios. ROC curve analysis demonstrated a robust predictive performance of IL-10 mRNA expression and the IL-6/IL-10 ratio for identifying CS-refractory patients. In conclusion, the expression of IL-10 and the IL-6/IL-10 ratio hold promise as early predictive biomarkers for CS treatment refractoriness in patients with non-infectious uveitis. These findings offer valuable insights into personalized treatment strategies, potentially leading to improved clinical outcomes.
dc.description.versionVersión Publicada
dc.identifier.citationValenzuela, R. A., Vega-Tapia, F., Elizalde, N., Flores, I., Rojas, F. M., Goecke, A., Cuitino, L., & Urzua, C. A. (2025). IL-10 and IL-6/IL-10 as predictive biomarkers for treatment response in non-infectious uveitis. Frontiers in immunology, 16, 1584905. https://doi.org/10.3389/fimmu.2025.1584905
dc.identifier.doihttps://doi.org/10.3389/fimmu.2025.1584905
dc.identifier.urihttps://hdl.handle.net/11447/11157
dc.language.isoen
dc.subjectBiomarkers
dc.subjectCorticosteroids
dc.subjectInterleukin-10
dc.subjectNon-infectious uveitis
dc.subjectRefractoriness
dc.subjectTreatment response
dc.titleIL-10 and IL-6/IL-10 as predictive biomarkers for treatment response in non-infectious uveitis
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceFrontiers in immunology
dspace.entity.typePublication
relation.isAuthorOfPublicationd1e93d92-ff40-419a-a8dd-1f0a39cd9e5e
relation.isAuthorOfPublication.latestForDiscoveryd1e93d92-ff40-419a-a8dd-1f0a39cd9e5e

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