Publication:
Association of Ventilatory Ratio with Acute Cor Pulmonale and Mortality in COVID-19 ARDS: A Cohort Study

Simple item page
dc.contributor.authorBenites, Martín
dc.contributor.authorBattiato, Romina
dc.contributor.authorMercado, Pablo
dc.contributor.authorPairumani, Ronald
dc.contributor.authorMedel, Juan
dc.contributor.authorPetruska, Edward
dc.contributor.authorUgalde, Diego
dc.contributor.authorMorales, Felipe
dc.contributor.authorEisen, Daniela
dc.contributor.authorAraya, Carla
dc.contributor.authorMontoya, Jorge
dc.contributor.authorRetamal, Jaime
dc.contributor.authorKattan, Eduardo
dc.contributor.authorBasoalto, Roque
dc.contributor.authorBugedo, Guillermo
dc.contributor.authorValenzuela, Emilio
dc.date.accessioned2026-11-03T17:20:56Z
dc.date.available2026-11-03T17:20:56Z
dc.date.issued2026
dc.description.abstractPurposeAn elevated ventilatory ratio (VR) and acute cor pulmonale (ACP) are associated with mortality in ARDS patients. The primary aim of this study was to assess the association between VR and ACP in patients with COVID-19-related ARDS (C-ARDS). The secondary objectives were to analyze the association between VR and ICU mortality, describe VR temporal behavior in survivors and non-survivors, and evaluate the association between VR and pulmonary embolism.Materials and MethodsWe studied a cohort of patients with C-ARDS. The VR was calculated using a validated formula. Echocardiography was used to diagnose ACP, and CT pulmonary angiography was performed to identify PE. To evaluate the associations between VR and ACP, mortality, and PE, a generalized logistic regression model was used.ResultsOf the 140 subjects, 60 (43%) had a VR < 2, while 80 (57%) had a VR ≥ 2. Patients with a VR ≥2 had a higher risk of developing ACP than those with a VR <2 (Odds Ratio (OR), 3.77; 95% CI: 1.30 - 8.72). The ICU mortality rate was 29%. Of the 40 patients who died, 30 (75%) had a VR ≥ 2. Mortality was significantly associated with VR ≥ 2 and driving pressure ≥ 15 cm H2O. In non-survivor patients with a VR < 2 at ICU admission, a significant increase in VR was observed over the 7-day observation period. No significant association was observed between PE and VR (p = .118).ConclusionElevated VR was associated with ACP in patients with C-ARDS. VR ≥ 2 combined with driving pressure ≥ 15 cm H2O significantly improved the ability to identify patients at risk for ACP. Additionally, at ICU admission, elevated VR values and initially low values that increased over the first week were associated with higher ICU mortality.
dc.description.versionVersión Publicada
dc.identifier.citationBenites, M. H., Battiato, R., Mercado, P., Pairumani, R., Medel, J. N., Petruska, E., Ugalde, D., Morales, F., Eisen, D., Araya, C., Montoya, J., Retamal, J., Kattan, E., Basoalto, R., Bugedo, G., & Valenzuela, E. D. (2026). Association of Ventilatory Ratio with Acute Cor Pulmonale and Mortality in COVID-19 ARDS: A Cohort Study. Journal of intensive care medicine, 41(1), 76–85. https://doi.org/10.1177/08850666251359548
dc.identifier.doihttps://doi.org/10.1177/08850666251359548
dc.identifier.urihttps://hdl.handle.net/11447/11311
dc.language.isoen
dc.subjectAcute Cor Pulmonale
dc.subjectAcute Respiratory Distress Syndrome
dc.subjectCOVID-19-associated ARDS
dc.subjectVentilatory Ratio
dc.titleAssociation of Ventilatory Ratio with Acute Cor Pulmonale and Mortality in COVID-19 ARDS: A Cohort Study
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceJournal of intensive care medicine
dspace.entity.typePublication
relation.isAuthorOfPublication4e3332b1-7515-4993-8bf0-7a3d87a3a0e4
relation.isAuthorOfPublication.latestForDiscovery4e3332b1-7515-4993-8bf0-7a3d87a3a0e4

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Association of Ventilatory Ratio with Acute.pdf
Size:
1.06 MB
Format:
Adobe Portable Document Format
Description:
Texto Completo
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
347 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services