Publication:
Qualitative and quantitative educational disparities and brain signatures in healthy aging and dementia across global settings

Simple item page
dc.contributor.authorGonzalez, Raul
dc.contributor.authorCruzat, Josephine
dc.contributor.authorHernández, Hernán
dc.contributor.authorMigeot, Joaquín
dc.contributor.authorLegaz, Agustina
dc.contributor.authorSantamaria, Hernando
dc.contributor.authorFittipaldi, Sol
dc.contributor.authorMaito, Marcelo
dc.contributor.authorMedel, Vicente
dc.contributor.authorTagliazucchi, Enzo
dc.contributor.authorBarttfeld, Pablo
dc.contributor.authorFranco-O'Byrne, Daniel
dc.contributor.authorCastro, Ana
dc.contributor.authorBorquez, Patricio
dc.contributor.authorAvila, José
dc.contributor.authorBehrens, Maria Isabel
dc.contributor.authorCustodio, Nilton
dc.contributor.authorFarombi, Temitope
dc.contributor.authorGarcía, Adolfo
dc.contributor.authorGarcia, Indira
dc.contributor.authorGodoy, Maria
dc.contributor.authorGonzalez, Cecilia
dc.contributor.authorHu, Kun
dc.contributor.authorLawlor, Brian
dc.contributor.authorMatallana, Diana
dc.contributor.authorMiller, Bruce
dc.contributor.authorOkada, Maira
dc.contributor.authorPina, Stefanie
dc.contributor.authorFrança, Elisa de Paula
dc.contributor.authorReyes, Pablo
dc.contributor.authorSlachevsky Chonchol, Andrea
dc.contributor.authorTakada, Leonel
dc.contributor.authorYener, Görsev
dc.contributor.authorCoronel, Carlos
dc.contributor.authorIbañez, Agustin
dc.date.accessioned2026-09-21T19:46:23Z
dc.date.available2026-09-21T19:46:23Z
dc.date.issued2025
dc.description.abstractBackground: While education is crucial for brain health, evidence mainly relies on individual measures of years of education (YoE), neglecting education quality (EQ). The effect of YoE and EQ on aging and dementia has not been compared. Methods: We conducted a cross-sectional assessment of the effect of EQ and YoE on brain health in 7533 subjects from 20 countries, including healthy controls (HCs), Alzheimer's disease (AD), and frontotemporal lobar degeneration (FTLD). EQ was based on country-level quality indicators provided by the programme for international student assessment (PISA). After applying neuroimage harmonization, we examined its effect, along with YoE, on gray matter volume and functional connectivity. Regression models were adjusted for age, sex, and cognition, controlling for multiple comparisons. The influence of image quality was assessed through sensitivity analysis. Data collection was conducted between June 1 and October 30, 2024. Findings: Less EQ and YoE were associated with brain alterations across groups. However, EQ had a stronger influence, mainly targeting the critical areas of each condition. At the whole-brain level, EQ influenced volume (HCs: Δmean = 2·0 [1·9-2·0] × 10-2, p < 10-5; AD: Δmean = 0·1 [-0·0 to 0·3] × 10-2, p = 0·18; FTLD: Δmean = 3·5 [3·0-4·0] × 10-2, p < 10-5; all with 95% confidence intervals) and networks (HCs: Δmean = 13·5 [13·2-13·7] × 10-2, p < 10-5; AD: Δmean = 5·9 [5·2-6·7] × 10-2, p < 10-5; FTLD: Δmean = 13·2 [11·2-13·7] × 10-2, p < 10-5) 1·3 to 7·0 times more than YoE. These effects remain robust despite variations in income and socioeconomic factors at country and individual levels. Interpretation: The results support the need to incorporate education quality into studying and improving brain health, underscoring the importance of country-level measures. Funding: Multi-partner consortium to expand dementia research in Latin America (ReDLat).
dc.description.versionVersión Publicada
dc.identifier.citationGonzalez-Gomez, R., Cruzat, J., Hernández, H., Migeot, J., Legaz, A., Santamaria-García, H., Fittipaldi, S., Maito, M. A., Medel, V., Tagliazucchi, E., Barttfeld, P., Franco-O'Byrne, D., Castro Laguardia, A. M., Borquez, P. A., Avila-Funes, J. A., Behrens, M. I., Custodio, N., Farombi, T., García, A. M., Garcia-Cordero, I., … Ibañez, A. (2025). Qualitative and quantitative educational disparities and brain signatures in healthy aging and dementia across global settings. EClinicalMedicine, 82, 103187. c
dc.identifier.doihttps://doi.org/10.1016/j.eclinm.2025.103187
dc.identifier.urihttps://hdl.handle.net/11447/11155
dc.language.isoen
dc.subjectAging and dementia
dc.subjectBrain health
dc.subjectEducation quality
dc.subjectEducational disparities
dc.subjectYears of education
dc.titleQualitative and quantitative educational disparities and brain signatures in healthy aging and dementia across global settings
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceEClinicalMedicine
dspace.entity.typePublication
relation.isAuthorOfPublicationb0cb6d05-60d8-4c6f-96ed-e0bd1460aa3c
relation.isAuthorOfPublicatione25c3d3e-63b5-4e04-951a-12a4989aa772
relation.isAuthorOfPublication.latestForDiscoveryb0cb6d05-60d8-4c6f-96ed-e0bd1460aa3c

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Qualitative and quantitative educational disparities and brain signatures in healthy aging and dementia across global settings.pdf
Size:
1.83 MB
Format:
Adobe Portable Document Format
Description:
Texto Completo
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
347 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services