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Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood

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dc.contributor.authorVerdolini, Norma
dc.contributor.authorBorràs, Roger
dc.contributor.authorSparacino, Giulio
dc.contributor.authorGarriga, Marina
dc.contributor.authorSagué, Maria
dc.contributor.authorMadero, Santiago
dc.contributor.authorPalacios, Roberto
dc.contributor.authorSerra, Maria
dc.contributor.authorFlorencia, Maria
dc.contributor.authorSalagre, Estela
dc.contributor.authorAedo, Alberto
dc.contributor.authorSalgado, Pilar
dc.contributor.authorMontoro, Irene
dc.contributor.authorSánchez, Vanessa
dc.contributor.authorPomarol, Edith
dc.contributor.authorRamos, Josep
dc.contributor.authorCarvalho, Andre
dc.contributor.authorGarcia, Clemente
dc.contributor.authorUndurraga, Juan
dc.contributor.authorReinares, María
dc.contributor.authorMartinez, Anabel
dc.contributor.authorBernardo, Miguel
dc.contributor.authorVieta, Eduard
dc.contributor.authorPacchiarotti, Isabella
dc.contributor.authorAmoretti, Silvia
dc.date.accessioned2023-04-24T13:53:58Z
dc.date.available2023-04-24T13:53:58Z
dc.date.issued2022
dc.description.abstractObjective: This study was aimed at identifying differences in the prodromal symptoms and their duration, risk factors and markers of vulnerability in patients presenting a first episode mania (FEM) or psychosis (FEP) with onset in late adolescence or adulthood in order to guide tailored treatment strategies. Methods: Patients with a FEM or FEP underwent a clinical assessment. Prodromes were evaluated with the Bipolar Prodrome Symptom Scale-Retrospective (BPSS-R). Chi-squared tests were conducted to assess specific prodromal symptoms, risk factors or markers of vulnerability between groups. Significant prodromal symptoms were entered in a stepwise forward logistic regression model. The probabilities of a gradual versus rapid onset pattern of the prodromes were computed with logistic regression models. Results: The total sample included 108 patients (FEM = 72, FEP = 36). Social isolation was associated with the prodromal stage of a FEP whilst Increased energy or goal-directed activity with the prodrome to a FEM. Physically slowed down presented the most gradual onset whilst Increased energy presented the most rapid. The presence of obstetric complications and difficulties in writing and reading during childhood were risk factors for FEP. As for markers of vulnerability, impairment in premorbid adjustment was characteristic of FEP patients. No specific risk factor or marker of vulnerability was identified for FEM. Conclusion: Early characteristics differentiating FEP from FEM were identified. These findings might help shape early identification and preventive intervention programmes.
dc.description.versionVersión aceptada
dc.identifier.citationVerdolini N, Borràs R, Sparacino G, Garriga M, Sagué-Vilavella M, Madero S, Palacios-Garrán R, Serra M, Forte MF, Salagre E, Aedo A, Salgado-Pineda P, Salvatierra IM, Sánchez Gistau V, Pomarol-Clotet E, Ramos-Quiroga JA, Carvalho AF, Garcia-Rizo C, Undurraga J, Reinares M, Martinez Aran A, Bernardo M, Vieta E, Pacchiarotti I, Amoretti S. Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood. Acta Psychiatr Scand. 2022 Jul;146(1):36-50. doi: 10.1111/acps.13415
dc.identifier.doihttps://doi.org/10.1111/acps.13415
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7367
dc.language.isoen
dc.subjectFirst episode mania
dc.subjectFirst episode psychosis
dc.subjectMarkers of vulnerability
dc.subjectProdromes
dc.subjectRisk factors
dc.titleProdromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood
dc.typeArticle
dcterms.accessRightsEmbargo
dcterms.sourceActa psychiatrica Scandinavica
dspace.entity.typePublication

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