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Current knowledge of immunosuppression as a risk factor for skin cancer development

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dc.contributor.authorRollan, María Paz
dc.contributor.authorCabrera, Raúl
dc.contributor.authorSchwartz, Robert A.
dc.date.accessioned2023-07-11T17:41:58Z
dc.date.available2023-07-11T17:41:58Z
dc.date.issued2022
dc.description.abstractThis review outlines our current understanding of the relationship between immunosuppression and skin cancer. Primary immunodeficiencies increase the incidence of skin cancer, but due to their low frequency, the establishment of accurate risk ratios remains lacking. Regarding secondary immunosuppression, available data demonstrate a significant increase of skin cancer in solid organ recipients, being the most common malignancy of this population. Immunosuppressive drugs have an important role in these patients, with an impact related to both the cumulative dose and the type of regimen used. The association of skin cancer and immunosuppressive drugs in non-transplant patients is conflictive for most of the drugs except for azathioprine. Many cancers lead to secondary immunosuppression as a mechanism for tumor growth and advancement, increasing the risk of progression of the primary tumor. Novel insights related with tumorigenesis and immune-escape mechanisms have led to promising new treatments in melanoma and squamous cell carcinoma
dc.description.versionVersión publicada
dc.identifier.citationRollan MP, Cabrera R, Schwartz RA. Current knowledge of immunosuppression as a risk factor for skin cancer development. Crit Rev Oncol Hematol. 2022 Sep;177:103754. doi: 10.1016/j.critrevonc.2022.103754.
dc.identifier.doihttps://doi.org/10.1016/j.critrevonc.2022.103754
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7706
dc.language.isoen
dc.subjectCarcinoma
dc.subjectSquamous Cell
dc.subjectHIV
dc.subjectImmunosuppression
dc.subjectImmunosuppressive Agents
dc.subjectMelanoma
dc.subjectPrimary Immunodeficiency Diseases
dc.subjectSkin Neoplasms
dc.subjectTransplant recipients
dc.titleCurrent knowledge of immunosuppression as a risk factor for skin cancer development
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceCritical Reviews in Oncology/Hematology
dspace.entity.typePublication
relation.isAuthorOfPublication25860818-82d2-43bb-8c8b-15d59f71b662
relation.isAuthorOfPublication00e7d56a-4549-41d5-8c78-f5df4cd223a2
relation.isAuthorOfPublication.latestForDiscovery25860818-82d2-43bb-8c8b-15d59f71b662

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