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Multiple clonal transmissions of clinically relevant extended-spectrum beta-lactamase–producing Escherichia coli among livestock, dogs, and wildlife in Chile

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dc.contributor.authorHayer, Juliette
dc.contributor.authorSalgado, Marília
dc.contributor.authorOpazo, Andrés
dc.contributor.authorGonzález, Paulina
dc.contributor.authorPiñeiro, Ana
dc.contributor.authorMunita, Jose M.
dc.contributor.authorRivas Jiménez, Lina María
dc.contributor.authorBenavides, Julio
dc.date.accessioned2024-05-24T17:00:13Z
dc.date.available2024-05-24T17:00:13Z
dc.date.issued2023
dc.description.abstractObjectives: Extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli) are a main cause of human deaths associated with antimicrobial resistance (AMR). Despite hundreds of reports of the faecal carriage of ESBL-E. coli in domestic and wild animals, the dynamics of its circulation remains poorly understood. Methods: We used whole genome sequencing of 19 ESBL-E. coli previously isolated in the same local setting from dogs, livestock, and a wild rodent in Central Chile to assess potential cross-species transmission of ESBL-E. coli. Results: Isolates harboured a large number of AMR (n = 95) and virulence (n = 45) genes, plasmids replicons (n = 24), and E. coli sequence types including top extraintestinal pathogenic E. coli ST410, ST58, ST88, and ST617. Almost identical clones (<50 single nucleotide polymorphisms difference, same antibiotic and heavy metal resistance genes, virulence genes, and plasmids) were found in faeces of dogs, cattle, or sheep from the same farm, and in a dog and a wild rodent living in proximity. Conclusions: To our knowledge, this is the first report of multiple clonal cross-species transmission of ESBL-E. coli in domestic and potentially wild animals of Latin America. Our results suggest that relatively rare spread of AMR across animal species can still occur by both clonal and plasmid dissemination. Our study highlights the need for establishing preventive measures to limit the circulation of these bacteria among animals in agricultural settings, particularly given the highly pathogenic profile of several E. coli strains detected in these animals.
dc.description.versionAceptada
dc.identifier.citationHayer J, Salgado-Caxito M, Opazo-Capurro A, Muñoz PG, Millán J, Piñeiro A, Munita JM, Rivas L, Benavides JA. Multiple clonal transmissions of clinically relevant extended-spectrum beta-lactamase-producing Escherichia coli among livestock, dogs, and wildlife in Chile. J Glob Antimicrob Resist. 2023 Sep;34:247-252. doi: 10.1016/j.jgar.2023.07.009.
dc.identifier.doihttps://doi.org/10.1016/j.jgar.2023.07.009 .
dc.identifier.urihttps://hdl.handle.net/11447/8874
dc.language.isoen
dc.subjectAntimicrobial resistance
dc.subjectDomestic animals
dc.subjectLatin America
dc.subjectRodent
dc.subjectWhole genome sequencing
dc.titleMultiple clonal transmissions of clinically relevant extended-spectrum beta-lactamase–producing Escherichia coli among livestock, dogs, and wildlife in Chile
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceJournal of Global Antimicrobial Resistance
dspace.entity.typePublication
relation.isAuthorOfPublicationec52b0bf-d0bc-4844-9531-eca4a65f2b8e
relation.isAuthorOfPublication2bf16b44-04d3-45fe-8dd0-dafa6322ca94
relation.isAuthorOfPublication.latestForDiscoveryec52b0bf-d0bc-4844-9531-eca4a65f2b8e

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