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Polycaprolactone-based scaffolds for guided tissue regeneration in periodontal therapy: A systematic review

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dc.contributor.authorAntunovic, Florencia
dc.contributor.authorTolosa, Felipe
dc.contributor.authorKlein, Katherine
dc.contributor.authorOcaranza, René
dc.date.accessioned2024-05-29T15:41:12Z
dc.date.available2024-05-29T15:41:12Z
dc.date.issued2023
dc.description.abstractBackground:Polycaprolactone (PCL) is a highly recognized synthetic polymer for its biocompatibility, ease of fabrication and mechanical strength in bone tissue engineering. Its applications have extended broadly, including regeneration of oral and maxillofacial lost tissues. Its usefulness has brought attention of researchers to regenerate periodontal lost tissues, including alveolar bone, periodontal ligament and cementum. The aim of this systematic review was to obtain an updated analysis of the contribution of PCL-based scaffolds in the alveolar bone regeneration process. Methods:This review adheres to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for systematic reviews. A computerized search of the PubMed, EBSCO, Scielo and Web of Science databases was performed, restricting literature search to published studies in English or Spanish between January 2002 and March 2023. Database search returned 248 studies which were screened based on title, author names and publication dates. Results:Data from 17 studies were reviewed and tabulated. All studies combined PCL with other biomaterials (such as Alginate, hydroxyapatite, bioactive glass, poly (lactic-co-glycolic acid)), growth factors (BMP-2, rhCEMP1), and/or mesenchymal stromal cells (adipose-derived, bone marrow, periodontal ligament or gingiva mesenchymal stromal cells). PCL scaffolds showed higher cell viability and osteoinductive potential when combined with bioactive agents. Complementary, its degradation rates were affected by the addition or exposure to specific substances, such as: Dopamine, Cerium Oxide, PLGA and hydrogen peroxide. Conclusions:PCL is an effective biomaterial for alveolar bone regeneration in periodontally affected teeth. It could be part of a new generation of biomaterials with improved regenerative potential.
dc.description.versionVersión publicada
dc.format.extent15 p.
dc.identifier.citationAntunovic F, Tolosa F, Klein C, Ocaranza R. Polycaprolactone-based scaffolds for guided tissue regeneration in periodontal therapy: A systematic review. J Appl Biomater Funct Mater. 2023 Jan-Dec;21:22808000231211416. doi: 10.1177/22808000231211416.
dc.identifier.doihttps://doi.org/10.1177/22808000231211416
dc.identifier.urihttps://hdl.handle.net/11447/8928
dc.language.isoen
dc.subjectPolycaprolactone scaffold
dc.subjectGuided bone regeneration
dc.subjectPeriodontal regeneration
dc.titlePolycaprolactone-based scaffolds for guided tissue regeneration in periodontal therapy: A systematic review
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceJournal of Applied Biomaterials & Functional Materials
dspace.entity.typePublication

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