Publication:
Non-Canonical WNT/Wnt5a Pathway Activity in Circulating Monocytes of Untreated Psoriatic Patients: An Exploratory Study of Its Association with Inflammatory Cytokines and Cardiovascular Risk Marker-ADAMTS7

Simple item page
dc.contributor.authorKarsulovic, Claudio
dc.contributor.authorLoyola, Khanty
dc.contributor.authorCabrera, Raúl
dc.contributor.authorPérez, Claudio
dc.contributor.authorHojman, Lia
dc.date.accessioned2023-04-03T15:43:09Z
dc.date.available2023-04-03T15:43:09Z
dc.date.issued2023
dc.description.abstractThe leading cause of death in psoriasis is cardiovascular disease. The determinants that induce the increase in this risk are not known. The systemic inflammatory process is dependent on lymphocytes and monocytes, as has been proposed. However, adaptation modules such as mTOR have recently been mentioned as having a role. Other factors, such as WNT and its non-canonical WNT5a-inducing pathway, are relevant in inflammation, cell migration, and neoangiogenesis. Thus, we studied circulating monocytes from untreated severe psoriatic patients and characterized inflammatory cytokines, chemokines, mTOR activity, and the cardiovascular risk marker ADAMTS7. Peripheral blood from ten severely psoriatic patients (Psoriasis severity index greater than 10) was extracted and age- and sex-matched with healthy subjects. Surface and intracellular flow cytometry were performed for cytokine, chemokine receptors, and mTOR activity. ADAMTS7 was measured using ELISA. Psoriatic patients had a higher frequency of WNT5a+ cells in monocytes, which also had higher levels of IL-1β, IL-6, CXCR3, CCR2, and phosphorylated S6R protein. We found that M1 monocytes are dominant in the WNT5a+ cell group, and intracellular levels of WNT5a were also augmented. Levels of WNT5a were correlated with ADAMTS7, a blood marker related to the pathogenesis of atheromatosis. WNT5a could be relevant to the cardiovascular risk of psoriatic patients considering its association with higher levels of inflammatory cytokines, chemokine receptors and the pro-atherogenic profile of circulating monocytes.
dc.description.versionVersión publicada
dc.identifier.citationKarsulovic C, Loyola K, Cabrera R, Perez C, Hojman L. Non-Canonical WNT/Wnt5a Pathway Activity in Circulating Monocytes of Untreated Psoriatic Patients: An Exploratory Study of Its Association with Inflammatory Cytokines and Cardiovascular Risk Marker-ADAMTS7. Biomedicines. 2023 Feb 16;11(2):577. doi: 10.3390/biomedicines11020577
dc.identifier.doihttps://doi.org/10.3390/biomedicines11020577
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7236
dc.language.isoen
dc.subjectMonocytes
dc.subjectWNT5a
dc.subjectCardiovascular risk
dc.subjectInflammation
dc.titleNon-Canonical WNT/Wnt5a Pathway Activity in Circulating Monocytes of Untreated Psoriatic Patients: An Exploratory Study of Its Association with Inflammatory Cytokines and Cardiovascular Risk Marker-ADAMTS7
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceBiomedicines
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Non-Canonical WNT Wnt5a Pathway Activity in Circulating.pdf
Size:
670.95 KB
Format:
Adobe Portable Document Format
Description:
Texto completo
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services