Publication:
Differences of affective and non-affective psychoses in early intervention services from Latin America

Simple item page
dc.contributor.authorCerqueira, Raphael
dc.contributor.authorZiebold, Carolina
dc.contributor.authorCavalcante, Daniel
dc.contributor.authorOliveira, Giovany
dc.contributor.authorVásquez, Javiera
dc.contributor.authorUndurraga, Juan
dc.contributor.authorGonzález, Alfonso
dc.contributor.authorNachar, Ruben
dc.contributor.authorLópez, Carlos
dc.contributor.authorNoto, Cristiano
dc.contributor.authorCrossley, Nicolas
dc.contributor.authorGadelha, Ary
dc.date.accessioned2023-04-14T16:42:29Z
dc.date.available2023-04-14T16:42:29Z
dc.date.issued2022
dc.description.abstractBackground: Psychosis presentation can be affected by genetic and environmental factors. Differentiating between affective and non-affective psychosis (A-FEP and NA-FEP, respectively) may influence treatment decisions and clinical outcomes. The objective of this paper is to examine differences between patients with A-FEP or NA-FEP in a Latin American sample. Methods: Patients from two cohorts of patients with a FEP recruited from Brazil and Chile. Subjects included were aged between 15 and 30 years, with an A-FEP or NA-FEP (schizophrenia-spectrum disorders) according to DSM-IV-TR. Sociodemographic data, duration of untreated psychosis and psychotic/mood symptoms were assessed. Generalized estimating equation models were used to assess clinical changes between baseline-follow-up according to diagnosis status. Results: A total of 265 subjects were included. Most of the subjects were male (70.9 %), mean age was 21.36 years. A-FEP and NA-FEP groups were similar in almost all sociodemographic variables, but A-FEP patients had a higher probability of being female. At baseline, the A-FEP group had more manic symptoms and a steeper reduction in manic symptoms scores during the follow- up. The NA-FEP group had more negative symptoms at baseline and a higher improvement during follow-up. All domains of The Positive and Negative Syndrome Scale improved for both groups. No difference for DUP and depression z-scores at baseline and follow-up. Limitations: The sample was recruited at tertiary hospitals, which may bias the sample towards more severe cases. Conclusions: This is the largest cohort comparing A-FEP and NA-FEP in Latin America. We found that features in FEP patients could be used to improve diagnosis and support treatment decisions.
dc.description.versionVersión enviada
dc.identifier.citationCerqueira RO, Ziebold C, Cavalcante D, Oliveira G, Vásquez J, Undurraga J, González-Valderrama A, Nachar R, Lopez-Jaramillo C, Noto C, Crossley N, Gadelha A. Differences of affective and non-affective psychoses in early intervention services from Latin America. J Affect Disord. 2022 Nov 1;316:83-90. doi: 10.1016/j.jad.2022.08.010
dc.identifier.doihttps://doi.org/10.1016/j.jad.2022.08.010
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7332
dc.language.isoen
dc.subjectBipolar disorder
dc.subjectDepression
dc.subjectFirst-episode
dc.subjectPsychosis
dc.subjectSchizophrenia
dc.titleDifferences of affective and non-affective psychoses in early intervention services from Latin America
dc.typeArticle
dcterms.accessRightsPrivado
dcterms.sourceJournal of Affective Disorders
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2. Differences of affective and non-affective psychoses in early.pdf
Size:
1.29 MB
Format:
Adobe Portable Document Format
Description:
Texto completo
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services