Publication:
Prevalence of chronic pulmonary aspergillosis regarding time of tuberculosis diagnosis in Brazil

Simple item page
dc.contributor.authorVolpe-Chaves, Cláudia E.
dc.contributor.authorVenturini, James
dc.contributor.authorCastilho, Suse B.
dc.contributor.authorFonseca, Simone S. O.
dc.contributor.authorNunes, Thiago F.
dc.contributor.authorCunha, Eunice A. T.
dc.contributor.authorLima, Gláucia M. E.
dc.contributor.authorNunes, Maína O.
dc.contributor.authorVicentini, Adriana P.
dc.contributor.authorOliveira, Sandra M. V. L.
dc.contributor.authorCarvalho, Lídia R.
dc.contributor.authorThompson, Luis
dc.contributor.authorMendes, Rinaldo P.
dc.contributor.authorPaniago, Anamaria M. M.
dc.date.accessioned2023-07-07T15:09:06Z
dc.date.available2023-07-07T15:09:06Z
dc.date.issued2022
dc.description.abstractBackground: Data on the prevalence of chronic pulmonary aspergillosis (CPA) in patients with active or cured tuberculosis (TB) are scarce, mainly due to diagnostic difficulties. The diagnosis of CPA is based on pulmonary symptoms and chest computed tomography (CT) scans and is considered confirmed when there is microbiological or serological evidence of Aspergillus spp. Objectives: To estimate the prevalence of CPA in patients treated or undergoing treatment for PTB, seen in two referral hospitals in Mato Grosso do Sul, Brazil. Patients and methods: A total of 193 consecutive patients who were treated or previously treated for pulmonary tuberculosis underwent prospective evaluation: (a) clinical evaluation; (b) chest CT scan; (c) sputum examination-culture for fungi and smears for direct mycology; (d) detection of anti-Aspergillus fumigatus antibodies using an enzyme-linked immunosorbent assay Platelia® test; and (e) anti-Aspergillus spp. antibodies were assessed via a DID test. Results: The global prevalence of CPA was 10.9% (95% confidence interval, 7.2%-16.1%), but it increased with the time of TB diagnosis. The variables independently associated with CPA were previous pulmonary tuberculosis over 4 years ago and haemoptysis. Cavities, pleural thickening and the presence of a fungal ball were the most frequent tomographic findings in patients with CPA. Conclusions: The high prevalence observed and its increase over time suggest the need for continuous surveillance of CPA in patients with active or previous pulmonary tuberculosis and throughout life, with clinical, tomographic and serological evaluations (ELISA) for a timely diagnosis and a better prognosis.
dc.description.versionVersión publicada
dc.format.extent9 p.
dc.identifier.citationMycoses. 2022 Jul;65(7):715-723
dc.identifier.doihttps://doi.org/10.1111/myc.13465
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7648
dc.language.isoen
dc.subjectAspergillus
dc.subjectBrazil
dc.subjectChronic cavitary pulmonary aspergillosis
dc.subjectChronic pulmonary aspergillosis
dc.subjectEnzyme-linked immunosorbent assay
dc.subjectFungal ball
dc.subjectPulmonary aspergilloma
dc.subjectPulmonary tuberculosis.
dc.titlePrevalence of chronic pulmonary aspergillosis regarding time of tuberculosis diagnosis in Brazil
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceMycoses
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Prevalence of chronic pulmonary aspergillosis regarding time of tuberculosis diagnosis in Brazil.pdf
Size:
1.63 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.63 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services