No evidence for exosome treatment in reducing alcohol relapse – a failed confirmatory multi-center study

Meinhardt, Marcus; Habelt, Bettina; Skorodumov, Ivan; Schwarz, Cindy; Bernhardt, Nadine; Winter, Christine; Hardar, Ravit; Müller, Christian; Israel, Yedy; Ezquer, Fernando; Spanagel, Rainer

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No evidence for exosome treatment in reducing alcohol relapse – a failed confirmatory multi-center study

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No evidence for exosome treatment in reducing alcohol relapse – a failed confirmatory multi-center study.pdf (2.47 MB)

Date

2025

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Article

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Artículos Medicina y Ciencias de la Salud

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Authors

Meinhardt, Marcus

Habelt, Bettina

Skorodumov, Ivan

Schwarz, Cindy

Bernhardt, Nadine

Winter, Christine

Hardar, Ravit

Müller, Christian

Israel, Yedy

Ezquer, Fernando

item.page.doiurl

https://doi.org/10.1016/j.addicn.2025.100234

URI

https://hdl.handle.net/11447/11061

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Abstract

Preclinical studies have suggested that intranasal administration of mesenchymal stem cell-derived exosomes can reduce alcohol intake and relapse-like behavior in rodents. To assess the translational ...

Citation

Marcus W. Meinhardt, Bettina Habelt, Ivan Skorodumov, Cindy Schwarz, Nadine Bernhardt, Christine Winter, Ravit Hardar, Christian P. Müller, Yedy Israel, Fernando Ezquer, Rainer Spanagel. No evidence for exosome treatment in reducing alcohol relapse – a failed confirmatory multi-center study, Addiction Neuroscience, Volume 17, 2025, 100234, ISSN 2772-3925, https://doi.org/10.1016/j.addicn.2025.100234

Keywords

Exosomes , Alcohol relapse , Multi-center , Addiction reserach , Reproducibility

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