Electroencephalographic response to transient adaptation of vestibular perception

Cooke, Josephine; Guven, Onur; Castro, Patricia; Ibitoye, Richard; Pettorossi, Vito; Bronstein, Adolfo

Publication:
Electroencephalographic response to transient adaptation of vestibular perception

dc.contributor.author	Cooke, Josephine
dc.contributor.author	Guven, Onur
dc.contributor.author	Castro, Patricia
dc.contributor.author	Ibitoye, Richard
dc.contributor.author	Pettorossi, Vito
dc.contributor.author	Bronstein, Adolfo
dc.date.accessioned	2023-07-07T16:03:21Z
dc.date.available	2023-07-07T16:03:21Z
dc.date.issued	2022
dc.description.abstract	When given a series of sinusoidal oscillations in which the two hemicycles have equal amplitude but asymmetric velocity, healthy subjects lose perception of the slower hemicycle (SHC), reporting a drift towards the faster hemicycle (FHC). This response is not reflected in the vestibular-ocular reflex, suggesting that the adaptation is of higher order. This study aimed to define EEG correlates of this adaptive response. Twenty-five subjects underwent a series of symmetric or asymmetric oscillations and reported their perceived head orientation at the end using landmarks in the testing room; this was converted into total position error (TPE). Thirty-two channel EEG was recorded before, during and after adaptation. Spectral power and coherence were calculated for the alpha, beta, delta and theta frequency bands. Linear mixed models were used to determine a region-by-condition effect of the adaptation. TPE was significantly greater in the asymmetric condition and reported error was always in the direction of the FHC. Regardless of condition, alpha desynchronised in response to stimulation, then rebounded back toward baseline values. This pattern was accelerated and attenuated in the prefrontal and occipital regions, respectively, in the asymmetric condition. Functional connectivity networks were identified in the beta and delta frequency bands; these networks, primarily comprising frontoparietal connections, were more coherent during asymmetric stimulation. These findings suggest that the temporary vestibulo-perceptual 'neglect' induced by asymmetric vestibular stimulation may be mediated by alpha rhythms and frontoparietal attentional networks. The results presented further our understanding of brain rhythms and cortical networks involved in vestibular perception and adaptation. KEY POINTS: Whole-body asymmetric sinusoidal oscillations, which consist of hemicycles with equal amplitude but differing velocities, can induce transient 'neglect' of the slower hemicycle in the vestibular perception of healthy subjects. In this study, we aimed to elucidate EEG correlates of this 'neglect', thereby identifying a cortical role in vestibular perception and adaptation. We identified a desynchronisation-resynchronisation response in the alpha frequency band (8-14 Hz) that was accelerated in the prefrontal region and attenuated in the occipital region when exposed to asymmetric, as compared to symmetric, rotations. We additionally identified functional connectivity networks in the beta (14-30 Hz) and delta (1-4 Hz) frequency bands consisting primarily of frontoparietal connections. These results suggest a prominent role of alpha rhythms and frontoparietal attentional networks in vestibular perception and adaptation.
dc.description.version	Versión Publicada
dc.identifier.citation	Cooke JI, Guven O, Castro Abarca P, Ibitoye RT, Pettorossi VE, Bronstein AM. Electroencephalographic response to transient adaptation of vestibular perception. J Physiol. 2022 Aug;600(15):3517-3535. doi: 10.1113/JP282470
dc.identifier.doi	https://doi.org/10.1113/JP282470
dc.identifier.uri	https://repositorio.udd.cl/handle/11447/7655
dc.language.iso	en
dc.subject	EEG
dc.subject	Adaptation
dc.subject	Alpha frequency
dc.subject	Asymmetric rotation
dc.subject	Frontoparietal
dc.subject	Vestibular perception
dc.title	Electroencephalographic response to transient adaptation of vestibular perception
dc.type	Article
dcterms.accessRights	Acceso Abierto
dcterms.source	The Journal of physiology
dspace.entity.type	Publication