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Reduction of nicotine and ethanol intake in alcohol-preferring (UChB) female rats by the α4β2 nicotinic acetylcholine receptor partial agonists 5-bromocytisine and cytisine

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dc.contributor.authorQuintanilla, María
dc.contributor.authorRivera, Mario
dc.contributor.authorBerríos, Pablo
dc.contributor.authorCassels, Bruce
dc.date.accessioned2024-06-03T19:07:41Z
dc.date.available2024-06-03T19:07:41Z
dc.date.issued2023
dc.description.abstractRationale: Neuronal nicotinic acetylcholine receptors (nAChRs) are implicated in the reinforcing effects of nicotine and ethanol. Previous studies have shown that cytisine and its 5-bromo derivative are partial agonists at the α4β2 nAChRs and that the parent molecule cytisine is effective in reducing both nicotine- and ethanol-self-administration in rats. However, whether 5-bromocytisine affects nicotine or ethanol self-administration was unknown. Objectives: The present study compared the effects of 5-bromocytisine and cytisine on nicotine self-administration and further assessed the effect of daily drug injection on voluntary ethanol consumption in alcohol-preferring female rats. Animals were administered a 1.5mg/kg i.p. dose of 5-bromocytisine or cytisine every day for 15-16 days. Results: The initial efficacy of 5-bromocytisine and cytisine in reducing nicotine intake was similar (-80%) while for voluntary ethanol intake 5-bromocytisine was a superior inhibitor over cytisine (-78% and -40% respectively). The efficacy of cytisine began to diminish after 10 days of daily administration, which was attributed to tolerance development to its inhibitory effects both on nicotine and ethanol self-administration. Tolerance did not develop for 5-bromocytisine. Conclusion: 5-Bromocytisine, a weaker α4β2 nAChR partial agonist than cytisine, also produces a sustained inhibition of both nicotine and ethanol self-administration, and unlike cytisine, it does not develop tolerance.
dc.description.versionAceptada
dc.identifier.citationQuintanilla ME, Rivera-Meza M, Berríos-Cárcamo P, Cassels BK. Reduction of nicotine and ethanol intake in alcohol-preferring (UChB) female rats by the α4β2 nicotinic acetylcholine receptor partial agonists 5-bromocytisine and cytisine. Drug Alcohol Depend. 2023 Sep 1;250:110900. doi: 10.1016/j.drugalcdep.2023.110900
dc.identifier.doihttps://doi.org/10.1016/j.drugalcdep.2023.110900
dc.identifier.urihttps://hdl.handle.net/11447/8999
dc.language.isoen
dc.subject5-Bromocytisine
dc.subjectCytisine
dc.subjectEthanol
dc.subjectNicotine
dc.subjectRats
dc.titleReduction of nicotine and ethanol intake in alcohol-preferring (UChB) female rats by the α4β2 nicotinic acetylcholine receptor partial agonists 5-bromocytisine and cytisine
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceDrug and alcohol dependence
dspace.entity.typePublication

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