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Transmission of gram‑negative antibiotic‑resistant bacteria following difering exposure to antibiotic‑resistance reservoirs in a rural community: a modelling study for bloodstream infections

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dc.contributor.authorAllel, Kasim
dc.contributor.authorGoscé, Lara
dc.contributor.authorAraos, Rafael
dc.contributor.authorToro, Daniel
dc.contributor.authorFerreccio, Catterina
dc.contributor.authorMunita, José
dc.contributor.authorUndurraga, Eduardo A.
dc.contributor.authorPanovska-Grifths, Jasmina
dc.date.accessioned2023-07-07T17:46:32Z
dc.date.available2023-07-07T17:46:32Z
dc.date.issued2022
dc.description.abstractExposure to community reservoirs of gram-negative antibiotic-resistant bacteria (GN-ARB) genes poses substantial health risks to individuals, complicating potential infections. Transmission networks and population dynamics remain unclear, particularly in resource-poor communities. We use a dynamic compartment model to assess GN-ARB transmission quantitatively, including the susceptible, colonised, infected, and removed populations at the community-hospital interface. We used two side streams to distinguish between individuals at high- and low-risk exposure to community ARB reservoirs. The model was calibrated using data from a cross-sectional cohort study (N= 357) in Chile and supplemented by existing literature. Most individuals acquired ARB from the community reservoirs (98%) rather than the hospital. High exposure to GN-ARB reservoirs was associated with 17% and 16% greater prevalence for GN-ARB carriage in the hospital and community settings, respectively. The higher exposure has led to 16% more infections and attributed mortality. Our results highlight the need for early-stage identifcation and testing capability of bloodstream infections caused by GN-ARB through a faster response at the community level, where most GN-ARB are likely to be acquired. Increasing treatment rates for individuals colonised or infected by GN-ARB and controlling the exposure to antibiotic consumption and GN-ARB reservoirs, is crucial to curve GN-ABR transmission .
dc.description.versionVersión publicada
dc.identifier.citationAllel, K., Goscé, L., Araos, R. et al. Transmission of gram-negative antibiotic-resistant bacteria following differing exposure to antibiotic-resistance reservoirs in a rural community: a modelling study for bloodstream infections. Sci Rep 12, 13488 (2022). https://doi.org/10.1038/s41598-022-17598-x
dc.identifier.doihttps://doi.org/10.1038/s41598-022-17598-x
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7665
dc.language.isoen
dc.subjectAntibiotics
dc.subjectCommunity reservoirs
dc.subjectARB
dc.titleTransmission of gram‑negative antibiotic‑resistant bacteria following difering exposure to antibiotic‑resistance reservoirs in a rural community: a modelling study for bloodstream infections
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceScientific Reports
dspace.entity.typePublication

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