Nanomaterials Based on Honey and Propolis for Wound Healing—A Mini-Review

Jaldin, Limberg; Silva, Nataly; Martínez, Jessica

Publication:
Nanomaterials Based on Honey and Propolis for Wound Healing—A Mini-Review

dc.contributor.author	Jaldin, Limberg
dc.contributor.author	Silva, Nataly
dc.contributor.author	Martínez, Jessica
dc.date.accessioned	2023-04-13T12:27:10Z
dc.date.available	2023-04-13T12:27:10Z
dc.date.issued	2022
dc.description.abstract	Wound healing is a public health concern worldwide, particularly in chronic wounds due to delayed healing and susceptibility to bacterial infection. Nanomaterials are widely used in wound healing treatments due to their unique properties associated with their size and very large surface-area-to-volume ratio compared to the same material in bulk. The properties of nanomaterials can be expanded and improved upon with the addition of honey and propolis, due to the presence of bioactive molecules such as polyphenols, flavonoids, peptides, and enzymes. These bionanomaterials can act at different stages of wound healing and through different mechanisms, including anti-inflammatory, antimicrobial, antioxidant, collagen synthesis stimulation, cell proliferation, and angiogenic effects. Biomaterials, at the nanoscale, show new alternatives for wound therapy, allowing for targeted and continuous delivery of beekeeping products at the injection site, thus avoiding possible systemic adverse effects. Here, we summarize the most recent therapies for wound healing based on bionanomaterials assisted by honey and propolis, with a focus on in vitro and in vivo studies. We highlight the type, composition (honey, propolis, and polymeric scaffolds), biological, physicochemical/mechanical properties, potential applications and patents related of the last eight years. Furthermore, we discuss the challenges, advantages, disadvantages and stability of different bionanomaterials related to their clinical translation and insight into the investigation and development of new treatments for wound healing.
dc.description.version	Versión publicada
dc.identifier.citation	Jaldin-Crespo L, Silva N, Martínez J. Nanomaterials Based on Honey and Propolis for Wound Healing-A Mini-Review. Nanomaterials (Basel). 2022 Dec 10;12(24):4409. doi: 10.3390/nano12244409
dc.identifier.uri	https://repositorio.udd.cl/handle/11447/7326
dc.language.iso	en
dc.subject	Wound healing
dc.subject	Bionanomaterials
dc.subject	Propolis
dc.subject	Honey
dc.title	Nanomaterials Based on Honey and Propolis for Wound Healing—A Mini-Review
dc.type	Article
dcterms.source	Nanomaterials
dspace.entity.type	Publication