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Ancient genomes reveal a deep history of Treponema pallidum in the Americas

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dc.contributor.authorBarquera, Rodrigo
dc.contributor.authorSitter, T. Lesley
dc.contributor.authorKirkpatrick, Casey L.
dc.contributor.authorRamirez, Darío A.
dc.contributor.authorKocher, Arthur
dc.contributor.authorSpyrou, Maria A.
dc.contributor.authorCouoh, Lourdes R.
dc.contributor.authorTalavera-González, Jorge A.
dc.contributor.authorCastro, Mario
dc.contributor.authorHunnius, Tanya von
dc.contributor.authorGuevara, Evelyn K.
dc.contributor.authorHamilton, W. Derek
dc.contributor.authorRoberts, Patrick
dc.contributor.authorScott, Erin
dc.contributor.authorFabra, Mariana
dc.contributor.authorDa Peña, Gabriela V.
dc.contributor.authorPacheco, Aryel
dc.contributor.authorRodriguez, Mónica
dc.contributor.authorAspillaga, Eugenio
dc.contributor.authorTiliakou, Anthi
dc.contributor.authorNelson, Elizabeth A.
dc.contributor.authorGiffin, Karen L.,
dc.contributor.authorBianco, Raffaela A.
dc.contributor.authorRohrlach, Adam B.
dc.contributor.authorGarcía Martínez, María de los Angeles
dc.contributor.authorBallesteros Solís, Fabiola A.
dc.contributor.authorSajantila, Antti
dc.contributor.authorSaunders, Shelley R.
dc.contributor.authorNores, Rodrigo
dc.contributor.authorHerbig, Alexander
dc.contributor.authorKrause, Johannes
dc.contributor.authorBos, Kirsten I.
dc.date.accessioned2026-07-22T17:17:26Z
dc.date.available2026-07-22T17:17:26Z
dc.date.issued2025
dc.description.abstractHuman treponemal infections are caused by a family of closely related Treponema pallidum that give rise to the diseases yaws, bejel, pinta and, most notably, syphilis1. Debates on a common origin for these pathogens and the history of syphilis itself have weighed evidence for the ‘Columbian hypothesis’2, which argues for an American origin, against that for the ‘pre-Columbian hypothesis’3, which argues for the presence of the disease in Eurasia in the Medieval period and possibly earlier. Although molecular data has provided a genetic basis for distinction of the typed subspecies4, deep evolution of the complex has remained unresolved owing to limitations in the conclusions that can be drawn from the sparse palaeogenomic data that are currently available. Here we explore this evolutionary history through analyses of five pre- and peri-contact ancient treponemal genomes from the Americas that represent ancient relatives of the T. pallidum subsp. pallidum (syphilis), T. pallidum subsp. pertenue (yaws) and T. pallidum subsp. endemicum (bejel) lineages. Our data indicate unexplored diversity and an emergence of T. pallidum that post-dates human occupation in the Americas. Together, these results support an American origin for all T. pallidum characterized at the genomic level, both modern and ancient.
dc.description.versionVersión publicada
dc.format.extent21 p.
dc.identifier.citationBarquera, R., Sitter, T.L., Kirkpatrick, C.L. et al. Ancient genomes reveal a deep history of Treponema pallidum in the Americas. Nature 640, 186–193 (2025). https://doi.org/10.1038/s41586-024-08515-5
dc.identifier.doihttps://doi.org/10.1038/s41586-024-08515-5
dc.identifier.urihttps://hdl.handle.net/11447/10896
dc.language.isoen
dc.subjectTreponema pallidum
dc.subjectDiseases
dc.subjectHistory
dc.titleAncient genomes reveal a deep history of Treponema pallidum in the Americas
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceNature
dspace.entity.typePublication

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