Betulinic Acid ω-Triphenylphosphonium Alkyl Esters: Antiproliferative Activities and In Silico Pharmacokinetic Profiles

Suárez, Cristian; Duarte, Claudia; Gajardo, Javier; Salgado, Paola; Salas, Julio; Cassels, Bruce; Theoduloz, Cristina; Jara, José; Fuentes, Sebastián; Campodónico, Paola; Soto, Jorge; Catalán, Mabel

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Betulinic Acid ω-Triphenylphosphonium Alkyl Esters: Antiproliferative Activities and In Silico Pharmacokinetic Profiles

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Betulinic Acid ω-Triphenylphosphonium Alkyl Esters.pdf (28.93 MB)

Date

2025

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Article

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Artículos Medicina y Ciencias de la Salud

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https://doi.org/10.3390/biomedicines13071539

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https://hdl.handle.net/11447/11025

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Abstract

Betulinic acid (BA) and some derivatives are well-known antiproliferative compounds. Literature precedents suggest that incorporating triphenylphosphonium (TPP+) salts on this triterpenoid scaffold en...

Citation

Suárez-Rozas C, Duarte-Salinas C, Gajardo-De la Fuente J, Salgado-Figueroa P, Salas-Norambuena J, Cassels BK, Theoduloz C, Jara JA, Fuentes-Retamal S, Campodónico PR, Soto-Delgado J, Catalán M. Betulinic Acid ω-Triphenylphosphonium Alkyl Esters: Antiproliferative Activities and In Silico Pharmacokinetic Profiles. Biomedicines. 2025 Jun 24;13(7):1539. doi: 10.3390/biomedicines13071539

Keywords

Antiproliferative activities , Betulinic acid derivatives , Cancer , Drugs discovery , Natural products , Synthetic strategy

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