Publication:
Association between spontaneous internal carotid artery dissection and perivascular adipose tissue attenuation on computed tomography angiography

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dc.contributor.authorCheng, Kevin
dc.contributor.authorLin, Andrew
dc.contributor.authorStecher, Ximena
dc.contributor.authorBernstein, Tomas
dc.contributor.authorZuñiga, Paulo
dc.contributor.authorMazzon, Enrico
dc.contributor.authorBrunse, Alejandro
dc.contributor.authorDiaz, Violeta
dc.contributor.authorMartinez, Gonzalo
dc.contributor.authorCameron, William
dc.contributor.authorNicholls, Stephen
dc.contributor.authorPatel, Sanjay
dc.contributor.authorDey, Damini
dc.contributor.authorWong, Dennis
dc.contributor.authorMuñoz Venturelli, Paula
dc.date.accessioned2023-04-26T16:05:09Z
dc.date.available2023-04-26T16:05:09Z
dc.date.issued2023
dc.description.abstractBackground: Spontaneous cervical artery dissection (sCAD) is a leading cause of ischemic stroke in young patients. Studies using high-resolution magnetic resonance imaging and positron emission tomography have suggested vessel wall inflammation to be a pathogenic factor in sCAD. Computed tomography (CT) attenuation of perivascular adipose tissue (PVAT) is an established non-invasive imaging biomarker of inflammation in coronary arteries, with higher attenuation values reflecting a greater degree of vascular inflammation. Objectives: We evaluate the CT attenuation of PVAT surrounding the internal carotid artery (PVATcarotid) with and without spontaneous dissection. Methods: Single-centre prospective observational study of 56 consecutive patients with CT-verified spontaneous dissection of the internal carotid artery (ICA) admitted between 2011 and 2018. Of these patients, 6 underwent follow-up CTA. 22 patients who underwent CTA for acute neurological symptoms but did not have dissection formed the control group. Using semiautomated research software, PVATcarotid was measured as the mean Hounsfield Unit (HU) attenuation of adipose tissue within a defined volume of interest surrounding the ICA. Results: PVATcarotid was significantly higher around dissected ICA compared with non-dissected contralateral ICA in the same patients (-58.7±10.2 vs. -68.9±8.1 HU, P<0.0001) and ICA of patients without dissection (-58.7±10.2 vs. -69.3±9.3 HU, P<0.0001). After a median follow-up of 89 days, there was a significant reduction in PVATcarotid around dissected ICA (from -57.5±13.4 to -74.3±10.5 HU, P<0.05); while no change was observed around non-dissected contralateral ICA (from -71.0±4.4 to -74.1±4.1 HU, P=0.19). ICA dissection was an independent predictor of PVATcarotid following multivariable adjustment for age and the presence of ICA occlusion.
dc.description.versionVersión Aceptada
dc.identifier.citationCheng K, Lin A, Stecher X, Bernstein T, Zuñiga P, Mazzon E, Brunser A, Diaz V, Martinez G, Cameron W, Nicholls S, Patel S, Dey D, Wong DTL, Munoz Venturelli P. Association Between Spontaneous Internal Carotid Artery Dissection and Perivascular Adipose Tissue Attenuation on Computed Tomography Angiography. Int J Stroke. 2023 Feb 7:17474930231158538. doi: 10.1177/17474930231158538
dc.identifier.doihttps://doi.org/10.1177/17474930231158538
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7399
dc.language.isoen
dc.subjectComputed tomography angiography
dc.subjectInflammation
dc.subjectInternal carotid artery
dc.subjectPerivascular adipose tissue
dc.subjectRadiology
dc.subjectSpontaneous dissection
dc.titleAssociation between spontaneous internal carotid artery dissection and perivascular adipose tissue attenuation on computed tomography angiography
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceInternational journal of stroke : official journal of the International Stroke Society
dspace.entity.typePublication

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