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Intragastric administration of short chain fatty acids greatly reduces voluntary ethanol intake in rats

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dc.contributor.authorQuintanilla, María
dc.contributor.authorSantapau, Daniela
dc.contributor.authorDiaz, Eugenio
dc.contributor.authorValenzuela, Ignacio
dc.contributor.authorMedina, Nicolas
dc.contributor.authorLandskron, Glauben
dc.contributor.authorDominguez, Antonia
dc.contributor.authorMorales, Paola
dc.contributor.authorRamírez, David
dc.contributor.authorHermoso, Marcela
dc.contributor.authorOlivares, Belén
dc.contributor.authorBerríos, Pablo
dc.contributor.authorEzquer, Marcelo
dc.contributor.authorHerrera, Mario
dc.contributor.authorIsrael, Yedy
dc.contributor.authorEzquer, Fernando
dc.date.accessioned2025-08-18T21:41:57Z
dc.date.available2025-08-18T21:41:57Z
dc.date.issued2024
dc.description.abstractAlcohol use disorder (AUD) represents a public health crisis with few FDA-approved medications for its treatment. Growing evidence supports the key role of the bidirectional communication between the gut microbiota and the central nervous system (CNS) during the initiation and progression of alcohol use disorder. Among the different protective molecules that could mediate this communication, short chain fatty acids (SCFAs) have emerged as attractive candidates, since these gut microbiota-derived molecules have multi-target effects that could normalize several of the functional and structural parameters altered by chronic alcohol abuse. The present study, conducted in male alcohol-preferring UChB rats, shows that the initiation of voluntary ethanol intake was inhibited in 85% by the intragastric administration of a combination of SCFAs (acetate, propionate and butyrate) given before ethanol exposure, while SCFAs administration after two months of ethanol intake induced a 90% reduction in its consumption. These SCFAs therapeutic effects were associated with (1) a significant reduction of ethanol-induced intestinal inflammation and damage; (2) reduction of plasma lipopolysaccharide levels and hepatic inflammation; (3) reduction of ethanol-induced astrocyte and microglia activation; and (4) attenuation of the ethanol-induced gene expression changes within the nucleus accumbens. Finally, we determined that among the different SCFAs evaluated, butyrate was the most potent, reducing chronic ethanol intake in a dose-response manner. These findings support a key role of SCFAs, and especially butyrate, in regulating AUD, providing a simple, inexpensive, and safe approach as a preventive and intervention-based strategy to address this devastating disease.
dc.description.versionVersión Publicada
dc.identifier.citationQuintanilla ME, Santapau D, Diaz E, Valenzuela Martinez I, Medina N, Landskron G, Dominguez A, Morales P, Ramírez D, Hermoso M, Olivares B, Berríos-Cárcamo P, Ezquer M, Herrera-Marschitz M, Israel Y, Ezquer F. Intragastric administration of short chain fatty acids greatly reduces voluntary ethanol intake in rats. Sci Rep. 2024 Nov 26;14(1):29260. doi: 10.1038/s41598-024-80228-1
dc.identifier.doihttps://doi.org/10.1038/s41598-024-80228-1
dc.identifier.urihttps://hdl.handle.net/11447/10177
dc.language.isoen
dc.subjectAlcohol abuse
dc.subjectAlcohol use disorder treatment
dc.subjectButyrate
dc.subjectGut microbiota-brain axis
dc.subjectSCFAs
dc.titleIntragastric administration of short chain fatty acids greatly reduces voluntary ethanol intake in rats
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceScientific reports
dspace.entity.typePublication
relation.isAuthorOfPublication9cd4a8e6-6ba1-4344-80a2-45c260864d4c
relation.isAuthorOfPublicationc74766c7-dad8-4d11-b35d-01da0664f3da
relation.isAuthorOfPublication.latestForDiscovery9cd4a8e6-6ba1-4344-80a2-45c260864d4c

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