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The Latin American Society for Immunodeficiencies Registry

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dc.contributor.authorSeminario, Gisela
dc.contributor.authorGonzalez, Maria
dc.contributor.authorSanchez, Carolina
dc.contributor.authorSevciovic, Anete
dc.contributor.authorRodrigues, Gesmar
dc.contributor.authorRegairaz, Lorena
dc.contributor.authorAlvares, Aristoteles
dc.contributor.authorLASID Registry Group
dc.contributor.authorAldave, Juan
dc.contributor.authorPoli Harlowe, María Cecilia
dc.contributor.authorKing, Alejandra
dc.contributor.authorRodrigues, Fatima
dc.contributor.authorLeiva, Lily
dc.contributor.authorFranco, Jose
dc.contributor.authorEspinosa, Francisco
dc.contributor.authorSorensen, Ricardo
dc.contributor.authorTavares, Beatriz
dc.contributor.authorBezrodnik, Liliana
dc.contributor.authorCondino, Antonio
dc.date.accessioned2026-08-10T21:17:49Z
dc.date.available2026-08-10T21:17:49Z
dc.date.issued2024
dc.description.abstractPurpose - The Latin American Society of Immunodeficiencies (LASID) Registry was established in 2009 to collect data on Inborn Errors of Immunity (IEI) patients in the region. Although several reports have been published regarding LASID data, this is the first report of the entire dataset. Methods - The European Society of Immunodeficiencies (ESID) donated the online platform in 2008. Data was collected from participating centers from Apr 13, 2009, to Dec 31, 2022, and included demographic, clinical, and follow-up information. Results - A total of 9307 patients were included in the database. At the end of the study period, 8,805 patients were alive or lost to follow-up, and 502 were deceased. The most common type of IEI was predominantly antibody deficiency (PAD, 60.35%), and selective IgA deficiency was the most frequent diagnosis (1627 patients, 17.48%), followed by Common Variable Immune Deficiency (CVID, 1191 patients). Most patients (78.16%) were ≤ 18 years old at inclusion, and the median age at diagnosis was 4.77 years. The median time to diagnosis was 5.04 years. Antibiotics were prescribed in 32.3% of visits, followed by immunoglobulins (29.49% ). Hematopoietic stem cell transplantation was performed in 5.03% of patients. Omenn syndrome was the most common disease in deceased patients, with a mortality rate of 52.63%. Conclusion - This study contributes to our understanding of IEIs in Latin America and highlights the importance of early diagnosis, appropriate treatments, and improved data collection to optimize patient outcome.
dc.description.versionVersión Publicada
dc.identifier.citationSeminario G, Gonzalez-Serrano ME, Aranda CS, Grumach AS, Segundo GRS, Regairaz L, Cardona AA; LASID Registry Group; Becerra JCA, Poli C, King A, Fernandes FR, Leiva L, Franco JL, Espinosa-Rosales FJ, Sorensen R, Costa Carvalho BT, Bezrodnik L, Condino-Neto A. The Latin American Society for Immunodeficiencies Registry. J Clin Immunol. 2024 Oct 22;45(1):28. doi: 10.1007/s10875-024-01822-6
dc.identifier.doihttps://doi.org/10.1007/s10875-024-01822-6
dc.identifier.urihttps://hdl.handle.net/11447/10990
dc.language.isoen
dc.subjectpidemiology
dc.subjectInborn errors of immunity
dc.subjectLatin America
dc.subjectPrimary immunodeficiency
dc.subjectRegistry
dc.titleThe Latin American Society for Immunodeficiencies Registry
dc.typeArticle
dcterms.sourceJournal of clinical immunology
dspace.entity.typePublication
relation.isAuthorOfPublicationbf711dbf-cd6f-4a66-97fb-64c15f664de3
relation.isAuthorOfPublication.latestForDiscoverybf711dbf-cd6f-4a66-97fb-64c15f664de3

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