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Dementia prevention requires moving beyond individual choice: the costs of effort and time intersect with social determinants of health

dc.contributor.authorMigeot, Joaquín
dc.contributor.authorAraya, Daniel
dc.contributor.authorMontecinos, Matias
dc.contributor.authorBaez, Sandra
dc.contributor.authorBehrens, Maria Isabel
dc.contributor.authorCastaner, Olga
dc.contributor.authorCruzat, Josephine
dc.contributor.authorDelgado, Carolina
dc.contributor.authorDe Jong- Bambagioni, David
dc.contributor.authorDuran, Claudia
dc.contributor.authorDurón, Dafne
dc.contributor.authorEvans, Tavia
dc.contributor.authorGonzalez, Raul
dc.contributor.authorGutiérrez, Myriam
dc.contributor.authorHayden, Katheen
dc.contributor.authorHernandez, Hernan
dc.contributor.authorIbañez, Agustin
dc.contributor.authorLegaz, Agustina
dc.contributor.authorMiller, Johnny
dc.contributor.authorMa iulskyt, Sonata
dc.contributor.authorPutthinun, Pongpat
dc.contributor.authorSantamaría, Hernando
dc.contributor.authorSlachevsky Chonchol, Andrea
dc.contributor.authorTrépel, Dominic
dc.date.accessioned2026-08-12T17:26:39Z
dc.date.available2026-08-12T17:26:39Z
dc.date.issued2025
dc.description.abstractSocial determinants of health strongly influence modifiable risk factors for dementia, yet prevention frameworks list only individual-level behaviours and conditions, overlooking the impact of social and environmental factors on the risk of dementia. In this perspective, we introduce the concept of non-monetary costs as a central mechanism through which social determinants shape modifiable risk factors by influencing individuals' ability to adopt healthy behaviours. Drawing from economic theory, we define non-monetary costs as the time and metabolic cost, perceived by individuals as physical and cognitive effort, required to engage in healthy behaviours. Under adverse social determinants of health, individuals effectively lack choice, as the non-monetary costs required to engage in healthy behaviours become prohibitively high. We propose a framework that links social determinants of health adversity to increased dementia risk through non-monetary costs. We apply this framework to each of the fourteen modifiable risk factors for dementia identified by the Lancet Commission, demonstrating how these costs systematically elevate risk in populations facing social adversity. Finally, we explore the implications of incorporating non-monetary cost assessments across research, interventions, clinical care, and public policy. We propose that quantifying and addressing these costs is essential for designing equitable, scalable, and contextually grounded strategies for dementia prevention across socially diverse populations.
dc.description.versionVersión Manuscrita
dc.identifier.citationMigeot J, Araya-Ríos D, Montecinos M, Baez S, Behrens MI, Castaner O, Cruzat J, Delgado C, De Jong-Bambagioni D, Duran-Aniotz C, Durón Reyes DE, Evans TE, Gonzalez-Gomez R, Gutiérrez M, Hayden KM, Hernandez H, Ibanez A, Legaz A, Miller J, Mačiulskytė S, Putthinun P, Santamaría-García H, Slachevsky A, Trépel D. Dementia prevention requires moving beyond individual choice: the costs of effort and time intersect with social determinants of health. Neuroscience. 2025 Nov 28;589:256-267. doi: 10.1016/j.neuroscience.2025.10.043
dc.identifier.doihttps://doi.org/10.1016/j.neuroscience.2025.10.043
dc.identifier.urihttps://hdl.handle.net/11447/11004
dc.language.isoen
dc.subjectDementia prevention
dc.subjectInterventions
dc.subjectModifiable risk factors
dc.subjectNon-monetary costs
dc.subjectSocial determinants of health
dc.titleDementia prevention requires moving beyond individual choice: the costs of effort and time intersect with social determinants of health
dc.typeArticle
dcterms.sourceNeuroscience
dspace.entity.typePublication
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relation.isAuthorOfPublicatione25c3d3e-63b5-4e04-951a-12a4989aa772
relation.isAuthorOfPublication.latestForDiscoveryb0cb6d05-60d8-4c6f-96ed-e0bd1460aa3c

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