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Effectiveness and safety of the tetravalent TAK-003 dengue vaccine: a systematic review

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dc.contributor.authorBengolea, AgustIn
dc.contributor.authorScigliano, Clara
dc.contributor.authorRamos, Jose
dc.contributor.authorRada, Gabriel
dc.contributor.authorCatalano, Hugo
dc.contributor.authorIzcovich, Ariel
dc.date.accessioned2025-01-21T14:16:36Z
dc.date.available2025-01-21T14:16:36Z
dc.date.issued2024
dc.description.abstractIn Argentina, the dengue virus has experienced an increase in recent years. This study aims to conduct a systematic review to evaluate the effectiveness and safety of the TAK-003 tetravalent dengue vaccine in this context. A systematic review of randomized controlled trials comparing the effectiveness and safety of the vaccine with placebo in the general population was conducted. The search was carried out in Epistemonikos, and two researchers independently assessed the studies. Risk of bias was evaluated using the Cochrane Rob 2 tool. A meta-analysis of the results was performed, and the certainty of evidence was assessed using the GRADE methodology. We concluded, with high certainty of evidence, that the tetravalent dengue vaccine reduces severe infections (RR 0.17, 95% CI 0.12 to 0.24) and infections by the dengue virus (RR 0.40, 95% CI 0.36 to 0.45) in a population ≤17 years. The vaccine may not increase the risk of serious adverse events, although it is important to note the low certainty of evidence (RR 1.04, 95% CI: 0.69-1.55). The use of the tetravalent dengue vaccine decreases the risk of severe and non-severe dengue infections in this population. However, there is low certainty of evidence regarding the vaccine's safety. The decision to vaccinate should consider the magnitude of benefits relative to the risk of infection.
dc.description.versionVersión Aceptada
dc.identifier.citationBengolea Agustín, Scigliano Clara, Ramos-Rojas Jose T., Rada Gabriel, Catalano Hugo N., Izcovich Ariel. Efectividad y seguridad de la vacuna tetravalente TAK-003 contra el dengue: una revisión sistemática. Medicina (B. Aires) [Internet]. 2024 Ago [citado 2025 Ene 21] ; 84( 4 ): 689-706. Disponible en: https://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802024000600689&lng=es
dc.identifier.urihttps://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802024000600689&lng=es
dc.identifier.urihttps://hdl.handle.net/11447/9684
dc.language.isoen
dc.subjectDengue
dc.subjectTetravalent vaccine
dc.subjectArgentina
dc.subjectGRADE
dc.subjectSystematic review
dc.titleEffectiveness and safety of the tetravalent TAK-003 dengue vaccine: a systematic review
dc.title.alternativeEfectividad y seguridad de la vacuna tetravalente TAK-003 contra el dengue: una revisión sistemática
dc.typeArticle
dcterms.sourceMedicina
dspace.entity.typePublication

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