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Demographic and Manometric Variables Can Independently Predict Gastroesophageal Reflux Disease: The AGES-D Score

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dc.contributor.authorReyes, Diego
dc.contributor.authorMuñoz, Ana
dc.contributor.authorCandia, Roberto
dc.contributor.authorRey, Paula
dc.contributor.authorChahuan, Javier
dc.contributor.authorGran, Ignacio
dc.contributor.authorRemes-Troche, José
dc.contributor.authorCisternas, Daniel
dc.contributor.authorMonrroy, Hugo
dc.date.accessioned2026-11-06T19:36:56Z
dc.date.available2026-11-06T19:36:56Z
dc.date.issued2025
dc.description.abstractObjective: Conclusive diagnosis of gastroesophageal reflux disease (GERD) can be challenging. When reflux monitoring is inconclusive, high-resolution esophageal manometry (HRM) may provide additional relevant information. We aimed to identify demographic and manometric parameters associated with GERD and to propose a diagnostic score. Methods: Adult patients with GERD symptoms who underwent reflux monitoring and HRM were considered for inclusion. The gold standard for GERD diagnosis was acid exposure time (AET); patients with AET>6% and AET<4% were included. Univariate and multivariate analyses were performed. A diagnostic score was developed using parameters independently associated with GERD. Generation and validation cohorts were randomly selected in a 2:1 ratio. Diagnostic accuracy was assessed using the area under the receiver operating characteristic curve (AUC ROC). Results: A total of 391 patients met the inclusion criteria; 167 had GERD (AET>6%) and 224 did not have GERD (AET<4%). In the multivariate analysis, age, male sex, and the distance between the lower esophageal sphincter and the crural diaphragm (LES-CD) were directly associated with GERD, while esophagogastric junction contractile integral (EGJ-CI) and distal contractile integral (DCI) were inversely associated with GERD (p values: 0.03, <0.01, <0.01, 0.01, and 0.01, respectively). The AUC ROC of a diagnostic score based on these parameters was 0.76 and 0.82 in the generation and validation cohorts, respectively. Conclusions: In this observational study, age, male sex, LES-CD distance, EGJ-CI, and DCI (AGES-D) were independently associated with GERD. A novel score incorporating these parameters could be useful in the assessment of inconclusive cases.
dc.description.versionVersión Aceptada
dc.identifier.citationReyes-Placencia, D., Muñoz, A., Candia, R., Rey, P., Chahuan, J., Gran, I., Remes-Troche, J. M., Cisternas, D., & Monrroy, H. (2025). Demographic and Manometric Variables Can Independently Predict Gastroesophageal Reflux Disease: The AGES-D Score. The Korean journal of helicobacter and upper gastrointestinal research, 25(3), 276–283. https://doi.org/10.7704/kjhugr.2025.0030
dc.identifier.doihttps://doi.org/10.7704/kjhugr.2025.0030
dc.identifier.urihttps://hdl.handle.net/11447/11336
dc.language.isoen
dc.subjectEsophagogastric junction
dc.subjectGastroesophageal reflux
dc.subjectEsophageal pH monitoring
dc.subjectManometry
dc.titleDemographic and Manometric Variables Can Independently Predict Gastroesophageal Reflux Disease: The AGES-D Score
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceThe Korean journal of helicobacter and upper gastrointestinal research
dspace.entity.typePublication
relation.isAuthorOfPublicatione1a01d35-b216-4a3e-bb07-f055e2f17eb9
relation.isAuthorOfPublication.latestForDiscoverye1a01d35-b216-4a3e-bb07-f055e2f17eb9

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